In the summer of 1984, both of us were working with Professor Yechiel Becker in the Laboratory for Molecular Virology at the Hebrew University-Hadassah Medical center in Jerusalem. During a discussion about the increasing number of specialized journals and monographs, Dr. Becker pointed out that none covered both the clinical and molecular aspects of neurotropic virus infections, and he urged us to develop such a book with the help of colleagues who were conducting highly-regarded research in their individual areas related to neurotropic viruses. The responses to our request were gratifying, and each contribution provided both a comprehensive clinical description of the neurologic disease produced by a specific virus and an up-to-date review of the current research in the pathogenesis of the disease, with particular attention given to molecular mechanisms. Most, but not all chapters were written by clinical neurologists who applied basic science strategies and methodologies to the question of how neurotropic viruses produce disease. other chapters were written by virologists known for their longstanding commitment and expertise in the analysis of the pathogenesis of neurotropic virus infections. Thus, this unique monograph should be valuable to all clinicians caring for patients with CNS viral diseases and to "neurovirologists" needing an update of the clinical and molecular pathogenesis of neurotropic virus infections. While this monograph was being prepared, a rapidly expanding literature indicated that the human lenteviruses, human immunodeficiency viruses (HIV) and HTLV-1 were highly neurotropic.

This second edition is a comprehensive study of the viruses that affect the brain and the central nervous system. Along with a focus on the viruses themselves, it addresses the diseases they cause, current treatments and preventive measures. Also discussed are the unique aspects of how viruses cause disease and why certain hosts are more susceptible (e.g., polymorphisms, age, co-morbidities). Because there are 29 cutting edge chapters, written by experts in the fields, Neurotropic Viral Infections has been divided into two separate volumes. Volume 1, Neurotropic RNA Viruses, includes 14 chapters on RNA viruses that cause human disease of the central nervous system ranging from Bornavirus to polio to West Nile. Volume 2, Neurotropic Retroviruses, DNA Viruses, Immunity and Transmission, includes 15 chapters divided into two parts. Part 1 includes 7 chapters on retroviruses and DNA viruses that cause human disease of the central nervous system ranging from HIV to varicella zoster virus. Part 2 includes chapters on transmission of these viruses by transplantation, bites by bats and insects, clinical management of the infections, and beneficial uses of attenuated viruses. Neurotropic Viral Infections is a unique resource, bridging basic, clinical, and translational approaches.​

The first book to specifically cover the molecular biology of retroviruses - of immense importance since the high profile of HIV. International contributors provide detailed reviews of the latest knowledge. An excellent text for both medical and non-medical researchers, it also serves as an illuminating introduction for scientists active in other areas.

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