This dissertation material provided in this work details the techniques that are developed to aid in the classification of tumors, non-tumors, and dense masses in a mammogram, certain characteristics such as texture in a mammographic image are used to identify the regions of interest as a part of classification. Pattern recognizing techniques such as nearest mean classifier and Support vector machine classifier are also used to classify the features. The initial stages include the processing of mammographic image to extract the relevant features that would be necessary for classification and during the final stage the features are classified using the pattern recognizing techniques mentioned above. The goal of this research work is to provide the Medical Experts and Researchers an effective method which would aid them in identifying the tumors, non-tumors, and dense masses in a mammogram. At first the breast region extraction is carried using the entire mammogram. The extraction is carried out by creating the masks and using those masks to extract the region of interest pertaining to the tumor. A chain code is employed to extract the various regions, the extracted regions could potentially be classified as tumors, non-tumors, and dense regions. Adaptive histogram equalization technique is employed to enhance the contrast of an image. After applying the adaptive histogram equalization for several times which will provide a saturated image which would contain only bright spots of the mammographic image which appear like dense regions of the mammogram. These dense masses could be potential tumors which would need treatment. Relevant Characteristics such as texture in the mammographic image are used for feature extraction by using the nearest mean and support vector machine classifier. A total of thirteen Haralick features are used to classify the three classes. Support vector machine classifier is used to classify two class problems and radial basis function (RBF) kernel is used to find the best possible (c and gamma) values. Results obtained in this research suggest the best classification accuracy was achieved by using the support vector machines for both Tumor vs Non-Tumor and Tumor vs Dense masses. The maximum accuracies achieved for the tumor and non-tumor is above 90 % and for the dense masses is 70.8% using 11 features for support vector machines. Support vector machines performed better than the nearest mean majority classifier in the classification of the classes. Various case studies were performed using two distinct datasets in which each dataset consisting of 24 patients' data in two individual views. Each patient data will consist of both the cranio caudal view and medio lateral oblique views. From these views the region of interest which could possibly be a tumor, non-tumor, or a dense regions(mass).

Holland-Frei Cancer Medicine, Ninth Edition, offers a balanced view of the most current knowledge of cancer science and clinical oncology practice. This all-new edition is the consummate reference source for medical oncologists, radiation oncologists, internists, surgical oncologists, and others who treat cancer patients. A translational perspective throughout, integrating cancer biology with cancer management providing an in depth understanding of the disease An emphasis on multidisciplinary, research-driven patient care to improve outcomes and optimal use of all appropriate therapies Cutting-edge coverage of personalized cancer care, including molecular diagnostics and therapeutics Concise, readable, clinically relevant text with algorithms, guidelines and insight into the use of both conventional and novel drugs Includes free access to the Wiley Digital Edition providing search across the book, the full reference list with web links, illustrations and photographs, and post-publication updates

Breast cancer is the most common type of cancer in women, which also causes the most cancer deaths among them today. Mammography is the only reliable method to detect breast cancer in the early stage among all diagnostic methods available currently. Breast cancer can occur in both men and women and is defined as an abnormal growth of cells in the breast that multiply uncontrollably. The main factors which cause breast cancer are either hormonal or genetic. Masses are quite subtle, and have many shapes such as circumscribed, speculated or ill-defined. These tumors can be either benign or malignant. Computer-aided methods are powerful tools to assist the medical staff in hospitals and lead to better and more accurate diagnosis. The main objective of this research is to develop a Computer Aided Diagnosis (CAD) system for finding the tumors in the mammographic images and classifying the tumors as benign or malignant. There are five main phases involved in the proposed CAD system: image pre-processing, extraction of features from mammographic images using Gabor Wavelet and Discrete Wavelet Transform (DWT), dimensionality reduction using Principal Component Analysis (PCA) and classification using Support Vector Machine (SVM) classifier.

Fractal analysis is useful in digital image processing for the characterization of shape roughness and gray-scale texture or complexity. Breast masses present shape and gray-scale characteristics in mammograms that vary between benign masses and malignant tumors. This book demonstrates the use of fractal analysis to classify breast masses as benign masses or malignant tumors based on the irregularity exhibited in their contours and the gray-scale variability exhibited in their mammographic images. A few different approaches are described to estimate the fractal dimension (FD) of the contour of a mass, including the ruler method, box-counting method, and the power spectral analysis (PSA) method. Procedures are also described for the estimation of the FD of the gray-scale image of a mass using the blanket method and the PSA method. To facilitate comparative analysis of FD as a feature for pattern classification of breast masses, several other shape features and texture measures are described in the book. The shape features described include compactness, spiculation index, fractional concavity, and Fourier factor. The texture measures described are statistical measures derived from the gray-level cooccurrence matrix of the given image. Texture measures reveal properties about the spatial distribution of the gray levels in the given image; therefore, the performance of texture measures may be dependent on the resolution of the image. For this reason, an analysis of the effect of spatial resolution or pixel size on texture measures in the classification of breast masses is presented in the book. The results demonstrated in the book indicate that fractal analysis is more suitable for characterization of the shape than the gray-level variations of breast masses, with area under the receiver operating characteristics of up to 0.93 with a dataset of 111 mammographic images of masses. The methods and results presented in the book are useful for computer-aided diagnosis of breast cancer. Table of Contents: Computer-Aided Diagnosis of Breast Cancer / Detection and Analysis of\newline Breast Masses / Datasets of Images of Breast Masses / Methods for Fractal Analysis / Pattern Classification / Results of Classification of Breast Masses / Concluding Remarks

This book provides a comprehensive description of the screening and clinical applications of digital breast tomosynthesis (DBT) and offers straightforward, clear guidance on use of the technique. Informative clinical cases are presented to illustrate how to take advantage of DBT in clinical practice. The importance of DBT as a diagnostic tool for both screening and diagnosis is increasing rapidly. DBT improves upon mammography by depicting breast tissue on a video clip made of cross‐sectional images reconstructed in correspondence with their mammographic planes of acquisition. DBT results in markedly reduced summation of overlapping breast tissue and offers the potential to improve mammographic breast cancer surveillance and diagnosis. This book will be an excellent practical teaching guide for beginners and a useful reference for more experienced radiologists.

Fractal analysis is useful in digital image processing for the characterization of shape roughness and gray-scale texture or complexity. Breast masses present shape and gray-scale characteristics in mammograms that vary between benign masses and malignant tumors. This book demonstrates the use of fractal analysis to classify breast masses as benign masses or malignant tumors based on the irregularity exhibited in their contours and the gray-scale variability exhibited in their mammographic images. A few different approaches are described to estimate the fractal dimension (FD) of the contour of a mass, including the ruler method, box-counting method, and the power spectral analysis (PSA) method. Procedures are also described for the estimation of the FD of the gray-scale image of a mass using the blanket method and the PSA method. To facilitate comparative analysis of FD as a feature for pattern classification of breast masses, several other shape features and texture measures are described in the book. The shape features described include compactness, spiculation index, fractional concavity, and Fourier factor. The texture measures described are statistical measures derived from the gray-level cooccurrence matrix of the given image. Texture measures reveal properties about the spatial distribution of the gray levels in the given image; therefore, the performance of texture measures may be dependent on the resolution of the image. For this reason, an analysis of the effect of spatial resolution or pixel size on texture measures in the classification of breast masses is presented in the book. The results demonstrated in the book indicate that fractal analysis is more suitable for characterization of the shape than the gray-level variations of breast masses, with area under the receiver operating characteristics of up to 0.93 with a dataset of 111 mammographic images of masses. The methods and results presented in the book are useful for computer-aided diagnosis of breast cancer. Table of Contents: Computer-Aided Diagnosis of Breast Cancer / Detection and Analysis of\newline Breast Masses / Datasets of Images of Breast Masses / Methods for Fractal Analysis / Pattern Classification / Results of Classification of Breast Masses / Concluding Remarks