This volume and its companion, Volume 339, supplement Volumes 176, 177, 239, and 261. Chapters are written with a "hands-on" perspective. That is, practical applications with critical evaluations of methodologies and experimental considerations needed to design, execute, and interpret NMR experiments pertinent to biological molecules.

This cutting-edge volume has been brought together in honor of Thomas Boomershine, author, scholar, storyteller, innovator. The particular occasion inviting this recognition of his work is the twenty-fifth anniversary of the Society of Biblical Literature's section on The Bible in Ancient and Modern Media (BAMM), which Tom was instrumental in founding. For two and half decades this program unit has provided scholars with opportunities to explore and experience biblical material in media other than silent print, including both oral and multimedia electronic performances. This book explores many, though by no means all, of the issues lifted up in those sessions over the years. Contributors A. K. M. Adam Adam Gilbert Bartholomew Arthur J. Dewey Dennis Dewey Joanna Dewey Robert M. Fowler Holly E. Hearon David Rhoads Philip Ruge-Jones Whitney T. Shiner Marti J. Steussy Richard W. Swanson

"The papers presented in this volume focus on a series of conservation 'flashpoints'-- painted works, drawings, sculpture, installations, new media, performance, interiors and historic houses, cultural objects-- and revolve around three key areas considered vital in establishing or vouchsafing an artwork's 'authenticity': material, concept and context. A wide range of approaches, some object-based, some more conceptual and philosophical, demonstrate that although the term authenticity is generally employed in the singular, the values associated with it are multiple, multilayered and often competing. The papers, each in their own way, evaluate the critical potential of the pluralised form, 'authenticities', creating a platform for a continuous discussion on this important and fascinating theme"--P. [4] of cover.

This book highlights the important role free fatty acids (FFA) play as potential drug targets. While FFA have long been considered byproducts of cell metabolism, they are now recognized as ligands that regulate cell and tissue function via G-protein-coupled receptors. At least three receptors have been identified for which FFA appear to be the endogenous ligands.

Essential Biochemistry, 3rd Edition is comprised of biology, pre-med and allied health topics and presents a broad, but not overwhelming, base of biochemical coverage that focuses on the chemistry behind the biology. Furthermore, it relates the chemical concepts that scaffold the biology of biochemistry, providing practical knowledge as well as many problem-solving opportunities to hone skills. Key Concepts and Concept Review features help students to identify and review important takeaways in each section.

G-protein-coupled receptors (GPCRs) are believed to be the largest family of membrane proteins involved in signal transduction and cellular responses. They dimerize (form a pair of macromolecules) with a wide variety of other receptors. The proposed book will provide a comprehensive overview of GPCR dimers, starting with a historical perspective and including, basic information about the different dimers, how they synthesize, their signaling properties, and the many diverse physiological processes in which they are involved. In addition to presenting information about healthy GPCR dimer activity, the book will also include a section on their pathology and therapeutic potentials.

G protein-coupled receptors (GPCRs) are the largest family of cell-surface receptors, with more than 800 members identified thus far in the human genome. They regulate the function of most cells in the body, and represent approximately 3% of the genes in the human genome. These receptors respond to a wide variety of structurally diverse ligands, ranging from small molecules, such as biogenic amines, nucleotides and ions, to lipids, peptides, proteins, and even light. Ligands (agonists and antagonists) acting on GPCRs are important in the treatment of numerous diseases, including cardiovascular and mental disorders, retinal degeneration, cancer, and AIDS. It is estimated that these receptors represent about one third of the actual identified targets of clinically used drugs. The determination of rhodopsin crystal structure and, more recently, of opsin, 1 and 2 adrenergic and A2A adenosine receptors provides both academia and industry with extremely valuable data for a better understanding of the molecular determinants of receptor function and a more reliable rationale for drug design. GPCR structure and function constitutes a hot topic. The book, which lies between the fields of chemical biology, molecular pharmacology and medicinal chemistry, is divided into three parts. The first part considers what receptor structures tell us about the mechanism of receptor activation. Part II focuses on receptor function. It discusses what the data from biophysical and mutational studies, and the analysis of the interactions of the receptor with ligands and regulator proteins, tell us about the process of signal transduction. The final part, on modelling and simulation, details new insights on the link between structure and mechanism and their implications in drug design.