Chemicals in the Environment and Brain Development: Importance of Neuroendocrinological Approaches
Title | Chemicals in the Environment and Brain Development: Importance of Neuroendocrinological Approaches PDF eBook |
Author | Fumihiko Maekawa |
Publisher | Frontiers Media SA |
Pages | 155 |
Release | 2017-05-11 |
Genre | |
ISBN | 2889451720 |
Mounting evidence shows that increasing numbers of children are being diagnosed with neurodevelopmental disorders, and it is clear that this increase cannot be explained by genetic background alone. A number of studies, including epidemiological studies, have found an association between in-utero and childhood exposure to certain chemicals, such as endocrine disruptors, psychoactive pharmaceuticals, volatile organic chemicals, persistent organic compounds and heavy metals, and children’s brain development. Yet, the mechanisms by which these chemicals impair brain development and function are not fully understood. In addition, little is known about how these chemicals enter and accumulate in the brain. Experimental approaches are essential to understand how those harmful chemicals enter children’s brain and pose discrete effects on specific brain sites. These approaches include the following: improvement of technologies for the detection and measurement of neuroendocrinological and behavioral changes in animal models: development of analytical methods for the identification and quantification of chemicals and their metabolites in the brain; development of in vitro cell line assays; and imaging technologies to illustrate cellular functions. In this research topic, we collected articles that provide state-of-the-art science and technologies that can help us identify environmental chemicals that influence brain development. We also included articles that lead to a better understanding of the actions and dynamics of these chemicals. The articles in this research topics supplied novel information about harmful endpoints of environmental chemicals. The reviews demonstrated the typical and novel interactions between environmental chemicals and the developing brain. We believe that these studies would lead to further understanding of neurodevelopmental disorders caused by environmental factors.
Understanding The Brain And Its Development: A Chemical Approach
Title | Understanding The Brain And Its Development: A Chemical Approach PDF eBook |
Author | Harun K M Yusuf |
Publisher | World Scientific Publishing Company |
Pages | 407 |
Release | 1992-11-20 |
Genre | Science |
ISBN | 9813103779 |
The understanding of brain functions at the molecular level has been one of the greatest challenges for man. Up to now, the basis of its most important functions, including the development of consciousness and personality, and the mechanism of learning and memory, remains unknown. However, the pace of discovery at the morphological, cellular, neurophysiological and molecular levels of brain functions has been quite rapid in the past decades. Neuroscience has therefore been an over-advancing and extremely fascinating field of research which has made a significant contribution to our understanding of brain structure, chemistry and function. This book gives a concise synopsis of our present day knowledge of the basic chemical principles of how the brain works and how the brain develops. It is quite an intelligible approach to ordering the tremendous amount of knowledge accumulated so far in various research fields, particularly neurochemistry. Special emphasis has been given to the chemical language of many aspects of brain development as related to morphology and function. The final part is devoted to the plasticity of the brain and the impact of malnutrition and environment in early life on the development of mental functions. Particularly valuable are the many references to original literature, especially when controversial issues are discussed.The book is well written in an easily understandable manner and would be of great help to all students and scientists interested in the extensive and demanding field of neuroscience.
Understanding the Brain and Its Development
Title | Understanding the Brain and Its Development PDF eBook |
Author | Harun K. M. Yusuf |
Publisher | |
Pages | 400 |
Release | 1992-11-01 |
Genre | Medical |
ISBN | 9789810204921 |
Environmental Neurotoxicology
Title | Environmental Neurotoxicology PDF eBook |
Author | National Research Council |
Publisher | National Academies Press |
Pages | 167 |
Release | 1992-02-01 |
Genre | Science |
ISBN | 0309045312 |
Scientists agree that exposure to toxic agents in the environment can cause neurological and psychiatric illnesses ranging from headaches and depression to syndromes resembling parkinsonism. It can even result in death at high exposure levels. The emergence of subclinical neurotoxicity-the concept that long-term impairments can escape clinical detection-makes the need for risk assessment even more critical. This volume paves the way toward definitive solutions, presenting the current consensus on risk assessment and environmental toxicants and offering specific recommendations. The book covers: The biologic basis of neurotoxicity. Progress in the application of biologic markers. Reviews of a wide range of in vitro and in vivo testing techniques. The use of surveillance and epidemiology to identify neurotoxic hazards that escape premarket screening. Research needs. This volume will be an important resource for policymakers, health specialists, researchers, and students.
Losing Our Minds
Title | Losing Our Minds PDF eBook |
Author | Barbara Demeneix |
Publisher | Oxford University Press, USA |
Pages | 313 |
Release | 2014 |
Genre | Medical |
ISBN | 0199917515 |
The exponential increases in neurodevelopmental disorders implicate both genetic causes and environmental factors. Flame-retardants, pesticides, plasticizers, and other every-day products contain chemicals shown to affect thyroid hormone signaling, which if disrupted can result in significant impairment to IQ. Across entire populations, such effects spell large-scale social and economic consequences. In this book Barbara Demeneix suggests what can and must be done to halt and reverse this disturbing trend.
Behavioral Measures of Neurotoxicity
Title | Behavioral Measures of Neurotoxicity PDF eBook |
Author | National Research Council |
Publisher | National Academies Press |
Pages | 449 |
Release | 1990-02-01 |
Genre | Science |
ISBN | 0309040477 |
Exposure to toxic chemicalsâ€"in the workplace and at homeâ€"is increasing every day. Human behavior can be affected by such exposure and can give important clues that a person or population is in danger. If we can understand the mechanisms of these changes, we can develop better ways of testing for toxic chemical exposure and, most important, better prevention programs. This volume explores the emerging field of neurobehavioral toxicology and the potential of behavior studies as a noninvasive and economical means for risk assessment and monitoring. Pioneers in this field explore its promise for detecting environmental toxins, protecting us from exposure, and treating those who are exposed.
Environmental Health Perspectives
Title | Environmental Health Perspectives PDF eBook |
Author | |
Publisher | |
Pages | 1490 |
Release | 2003 |
Genre | Environmental health |
ISBN |