Characterization and Biology of Nanomaterials for Drug Delivery: Nanoscience and Nanotechnology in Drug Delivery describes the techniques successfully employed for the application of nanocarriers loaded with the antioxidant enzyme, catalase, and thus targeted to endothelial cells. Methods of nanocarrier synthesis, loading within various systems, and the characterization of nanocarriers for targeting activities are covered, as are their advantages, disadvantages and applications. Reflecting the interdisciplinary nature of the subject matter, this book includes contributions by experts from different fields, all with various backgrounds and expertise. It will appeal to researchers and students from different disciplines, such as materials science, technology and various biomedical fields. - Enables readers from different fields to access recent research and protocols across traditional boundaries - Focuses on protocols and techniques, as well as the knowledge base of the field, thus enabling those in R&D to learn about, and successfully deploy, cutting-edge techniques - Explores both current and emerging classes of nanomaterials, along with their fundamentals and applications

Exploring fundamental concepts, Drug Delivery Nanoparticles Formulation and Characterization presents key aspects of nanoparticulate system development for various therapeutic applications and provides advanced methods used to file for regulatory approval.This comprehensive guide features:Process Analytical Techniques (PAT) used in manufacturing Na

Nanotechnology has the potential to change every part of our lives. Today, nanotechnology-based products are used in many areas, and one of the most important areas is drug delivery. Nanoparticulate drug delivery systems not only provide controlled delivery of drugs and improved drug solubility but also improve drug efficiency and reduce side effects via targeting mechanisms. However, compared with conventional drug delivery systems, few nanoparticle-based products are on the market and almost all are nontargeted or only passively targeted systems. In addition, obtaining targeted nanoparticle systems is quite complex and requires several evaluation mechanisms. This book discusses the production, characterization, regulation, and currently marketed targeted nanoparticle systems in a broad framework. It provides an overview of targeted nanoparticles’ (i) in vitro characterization, such as particle size, stability, ligand density, and type; (ii) in vivo behavior for different targeting areas, such as tumor, brain, and vagina; and (iii) current advances in this field, including clinical trials and regulation processes.

This fully updated volume presents a wide range of methods for synthesis, surface modification, characterization and application of nano-sized materials (nanoparticles) in the life science and medical fields, with a focus on drug delivery and diagnostics. Beginning with a section on the synthesis of nanoparticles and their applications, the book continues with detailed chapters on nanoparticle derivatization, bio-interface, and nanotoxicity, as well as nanoparticle characterization and advanced methods development. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Nanoparticles in Biology and Medicine: Methods and Protocols, Second Edition serves as an ideal guide for scientists at all levels of expertise to a wide range of biomedical and pharmaceutical applications including functional protein studies, drug delivery, immunochemistry, imaging, and more.

The synthesis and characterization of nanocomposites for drug delivery applications is an emerging field that aims to develop safe and effective drug delivery systems with enhanced therapeutic efficacy. Nanocomposites are composed of different types of nanoparticles, polymers, and other materials that can be precisely engineered to achieve specific drug delivery goals. These materials are typically biocompatible and biodegradable, allowing for controlled release of drugs over an extended period of time. The synthesis and characterization of nanocomposites involve the preparation of the nanoparticles and their subsequent incorporation into the polymer matrix or other material. Different types of nanoparticles, such as magnetic nanoparticles, gold nanoparticles, carbon nanotubes, and lipid-based nanoparticles, can be utilized depending on the intended application. Surface modification techniques can be employed to enhance the stability, biocompatibility, and specificity of the nanocomposites for targeted drug delivery. Characterization of nanocomposites is crucial to understanding their physicochemical properties, drug-loading capacity, and drug release kinetics. Techniques such as dynamic light scattering, scanning electron microscopy, transmission electron microscopy, X-ray diffraction, and Fourier-transform infrared spectroscopy can be used to characterize the nanocomposites. The use of nanocomposites for drug delivery applications has several advantages, including improved drug solubility, enhanced bioavailability, and reduced toxicity. Moreover, the development of stimuli-responsive nanocomposites that respond to changes in environmental factors such as pH, temperature, and magnetic field can further enhance drug delivery efficacy. The synthesis and characterization of nanocomposites for drug delivery applications represent a promising approach for the development of safe and effective drug delivery systems with enhanced therapeutic efficacy. However, further studies are needed to optimize the design of nanocomposites and to assess their toxicity and biocompatibility. Nanomaterial has promising application of all technology development. Nanomaterial has one or more dimension in the nanometer scale (100 nm) range and subsequently show novel properties from their bulk materials. Nanotechnology, led by the development of nanoparticles (NPs) -based drug delivery systems and imaging contrast agents, has had an important role in diagnosis, prevention, and treatment of the disease. The use of nanotechnology for cancer therapy and imaging is expected to overcome the limitations of conventional treatments, such as poor drug bioavailability, nonspecific systemic drug distribution, inadequate drug concentrations reaching the tumor and inability to monitor therapeutic responses in real time.