This issue of Physical Medicine and Rehabilitation Clinics of North America is devoted to "Difficult to Treat Pain Syndromes," and is edited by Adam L. Schreiber, DO of the Jefferson Medical College of Thomas Jefferson University. Articles in this issue will include: Carpal Tunnel Syndrome Diagnosis; Non-surgical Treatment of Carpal Tunnel Syndrome; Parsonage Turner Syndrome Diagnosis and Treatment; Trochanteric Pain Syndrome Diagnosis and Treatment; Complex Regional Pain Syndrome Diagnosis and Treatment; Discogenic Spine Pain Syndrome Diagnosis and Treatment; Failed Back Surgery Syndrome Diagnosis and Treatment; Myofascial Pain Syndrome Diagnosis and Treatments; Opioid Syndrome Diagnosis and Treatment; Spinal Cord Pain Syndrome Diagnosis and Treatment; Cerebral Vascular Accident Hemishoulder Pain Syndrome Diagnosis and Treatment; and Cancer Pain Syndromes.

This issue of Physical Medicine and Rehabilitation Clinics of North America is devoted to "Amputee Rehabilitation." Editor Robert Meier, III, MD is the Medical Director of the Amputee Services of America and has assembled the top experts to review this important topic. Articles in this issue include: Principles of Contemporary Amputee Rehabilitation; Etiology and Demographics of Amputation; Surgical Techniques for Ideal Outcomes; Pre-prosthetic Care; Prosthetic Choices for Leg and Arm Amputees; Devising the Prosthetic Prescription and Typical Examples; Prosthetic Training; Complications Following an Amputation; Outcomes Measurement; Gait Evaluation for the Leg Amputee; Innovative Techniques and Future Options; Emotional Adaptation to Limb Loss; Pain Management for the Amputee; and Amputation Classification and Functional Outcomes.

Children with disabilities represent a unique population within pediatrics. Pediatric rehabilitation focuses on maximizing the function and enhancing the lives of children with a wide range of conditions such as cerebral palsy, spina bifida, stroke, brain injury, genetic abnormalities and other developmental disabilities.

Physiatrists design plans that not only treat chronic pain, but also the whole patient who lives with the pain. Causes of chronic pain can include arthritis, work injuries, failed back surgery, foot and ankle injuries, knee and hip injuries, neck, shoulder, and back injuries, nerve (neuropathic) pain, etc. This issue will focus on everything from assessment, to various treatment options (medications and injections), as well as rehab.

This issue includes a range of topics in SCI from acute neuroprotection to chronic complications, focusing on some of the technological advances that have informed specific areas.

Drug overdose, driven largely by overdose related to the use of opioids, is now the leading cause of unintentional injury death in the United States. The ongoing opioid crisis lies at the intersection of two public health challenges: reducing the burden of suffering from pain and containing the rising toll of the harms that can arise from the use of opioid medications. Chronic pain and opioid use disorder both represent complex human conditions affecting millions of Americans and causing untold disability and loss of function. In the context of the growing opioid problem, the U.S. Food and Drug Administration (FDA) launched an Opioids Action Plan in early 2016. As part of this plan, the FDA asked the National Academies of Sciences, Engineering, and Medicine to convene a committee to update the state of the science on pain research, care, and education and to identify actions the FDA and others can take to respond to the opioid epidemic, with a particular focus on informing FDA's development of a formal method for incorporating individual and societal considerations into its risk-benefit framework for opioid approval and monitoring.

This issue is a comprehensive, multi-disciplinary state-of-the-art review focusing on the athlete as a whole. The articles explore the impact of excessive activity, new therapies and performance enhancement interventions on the musculoskeletal, neurological and psychological aspects of the athlete.