This book will familiarize the reader with the basic principles of perfusion MR imaging. Relevant technical aspects, contrast agents, and the postprocessing of images are presented, and imaging protocols are provided. Dedicated software for personal use on the postprocessing of images is provided on a CD-ROM containing hundreds of images and movie clips that demonstrate all concepts. In addition to the technical details of acquisition and postprocessing, numerous examples of the application of these tools in the clinical setting are also shown. In particular, the book includes a discussion of the role of perfusion MRI in the current evaluation of cerebrovascular disease, including an integrative approach using diffusion in conjunction with perfusion imaging. This text covers: all relevant technical aspects of perfusion MR imaging imaging protocols application of these tools in a clinical setting integration of diffusion imaging with perfusion imaging for enhanced diagnostic capabilities Also addressed are the role of perfusion MRI in the assessment of cerebral neoplasia, challenges and opportunities for treatment that tumors present, and the particular strengths of perfusion MRI, such as its relatively high resolution and possible microvascular specificity. For both newcomers and experienced practitioners, this is a nuts-and-bolts description of an important new technique.

This concise and comprehensive review uniquely contains all the information required to perform and interpret clinical MR perfusion imaging.

Covers each physiological MR methodology and their applications to all major neurological diseases.

Essential reading for both clinicians and researchers, this comprehensive resource covers what you need to know about the basic principles of perfusion, as well as its many clinical applications. Broad coverage outlines the overarching framework that interlinks methods such as DSC, DCE, CTP, and ASL. International experts in the field demonstrate how perfusion and pharmacokinetic imaging can be effectively used to analyze medical conditions, helping you reach accurate diagnoses and monitor disease progression and response to therapy.

Intravoxel incoherent motion (IVIM) refers to translational movements which within a given voxel and during the measurement time present a distribution of speeds in orientation and/or amplitude. The concept was introduced in 1986 together with the foundation of diffusion MRI because it had been realized that flow of blood in capillaries (perfusion) would mimic a diffusion process and impact diffusion MRI measurements. IVIM-based perfusion MRI, which does not require injection of any tracer or contrast agent, has been first investigated in the brain, but is now experiencing a remarkable revival for applications throughout the body, especially for oncologic applications, from diagnosis to treatment monitoring. This book addresses a number of highly topical aspects of the field from leading authorities, introducing the concepts behind IVIM MRI, outlining related methodological issues, and summarizing its current usage and potential for clinical applications. It also presents future research directions, both in terms of methodological development and clinical application fields, extending to new, non-perfusion applications of IVIM MRI, such as virtual MR elastography.

Established as the leading textbook on imaging diagnosis of brain and spine disorders, Magnetic Resonance Imaging of the Brain and Spine is now in its Fourth Edition. This thoroughly updated two-volume reference delivers cutting-edge information on nearly every aspect of clinical neuroradiology. Expert neuroradiologists, innovative renowned MRI physicists, and experienced leading clinical neurospecialists from all over the world show how to generate state-of-the-art images and define diagnoses from crucial clinical/pathologic MR imaging correlations for neurologic, neurosurgical, and psychiatric diseases spanning fetal CNS anomalies to disorders of the aging brain. Highlights of this edition include over 6,800 images of remarkable quality, more color images, and new information using advanced techniques, including perfusion and diffusion MRI and functional MRI. A companion Website will offer the fully searchable text and an image bank.