The Safety Critical Systems Handbook: A Straightforward Guide to Functional Safety: IEC 61508 (2010 Edition), IEC 61511 (2016 Edition) & Related Guidance, Fourth Edition, presents the latest on the electrical, electronic, and programmable electronic systems that provide safety functions that guard workers and the public against injury or death, and the environment against pollution. The international functional safety standard IEC 61508 was revised in 2010, and authors David Smith and Kenneth Simpson provide a comprehensive guide to the revised standard, as well as the revised IEC 61511 (2016). The book enables engineers to determine if a proposed or existing piece of equipment meets the safety integrity levels (SIL) required by the various standards and guidance, and also describes the requirements for the new alternative route (route 2H), introduced in 2010. A number of other areas have been updated by Smith and Simpson in this new edition, including the estimation of common cause failure, calculation of PFDs and failure rates for redundant configurations, societal risk, and additional second tier guidance documents. As functional safety is applicable to many industries, this book will have a wide readership beyond the chemical and process sector, including oil and gas, machinery, power generation, nuclear, aircraft, and automotive industries, plus project, instrumentation, design, and control engineers. - Provides the only comprehensive guide to IEC 61508, updated to cover the 2010 amendments, that will ensure engineers are compliant with the latest process safety systems design and operation standards - Addresses the 2016 updates to IEC 61511 to helps readers understand the processes required to apply safety critical systems standards and guidance - Presents a real-world approach that helps users interpret new standards, with case studies and best practice design examples throughout

Safety Critical Systems Handbook: A Straightfoward Guide to Functional Safety, IEC 61508 (2010 Edition) and Related Standards, Including Process IEC 61511 and Machinery IEC 62061 AND ISO 13849, Third Edition, offers a practical guide to the functional safety standard IEC 61508. The book is organized into three parts. Part A discusses the concept of functional safety and the need to express targets by means of safety integrity levels. It places functional safety in context, along with risk assessment, likelihood of fatality, and the cost of conformance. It also explains the life-cycle approach, together with the basic outline of IEC 61508 (known as BS EN 61508 in the UK). Part B discusses functional safety standards for the process, oil, and gas industries; the machinery sector; and other industries such as rail, automotive, avionics, and medical electrical equipment. Part C presents case studies in the form of exercises and examples. These studies cover SIL targeting for a pressure let-down system, burner control system assessment, SIL targeting, a hypothetical proposal for a rail-train braking system, and hydroelectric dam and tidal gates. - The only comprehensive guide to IEC 61508, updated to cover the 2010 amendments, that will ensure engineers are compliant with the latest process safety systems design and operation standards - Helps readers understand the process required to apply safety critical systems standards - Real-world approach helps users to interpret the standard, with case studies and best practice design examples throughout

This book is designed to meet the needs of both novice and senior researchers in Orthopaedics by providing the essential, clinically relevant knowledge on research methodology that is sometimes overlooked during training. Readers will find a wealth of easy-to-understand information on all relevant aspects, from protocol design, the fundamentals of statistics, and the use of computer-based tools through to the performance of clinical studies with different levels of evidence, multicenter studies, systematic reviews, meta-analyses, and economic health care studies. A key feature is a series of typical case examples that will facilitate use of the volume as a handbook for most common research approaches and study types. Younger researchers will also appreciate the guidance on preparation of abstracts, poster and paper presentations, grant applications, and publications. The authors are internationally renowned orthopaedic surgeons with extensive research experience and the book is published in collaboration with ISAKOS.

This handbook studies the combination of various methods of designing for reliability, availability, maintainability and safety, as well as the latest techniques in probability and possibility modeling, mathematical algorithmic modeling, evolutionary algorithmic modeling, symbolic logic modeling, artificial intelligence modeling and object-oriented computer modeling.

This book offers a practical guide to endovascular treatment of cerebrovascular disease and provides a concise reference for the related neurovascular anatomy and the various disorders that affect the vascular system. Fully revised and updated, the information is accessible and easy to read. It discusses fundamental principles underlying cerebral and spinal angiography; interventional techniques, devices, and practice guidelines; and commonly encountered cerebrovascular disorders for which interventional and endovascular methods are appropriate. New topics and features include: intracerebral and intraventricular hemorrhage; intracranial tumor embolization; vasculitis work-up and management; percutaneous carotid artery puncture technique; and pediatric aspects of neurointerventional techniques and disease states. Handbook of Cerebrovascular Disease and Neurointerventional Technique, 3rd Edition, is a portable and concise resource for interventional neuroradiologists, neurologists, neurosurgeons, cardiologists, and vascular surgeons.