This case study is about a 29-year-old professional oboe player who was first diagnosed for optic neuritis and then for multiple sclerosis (MS). MS is an example of a T-cell mediated autoimmune disease, wherein there is an autoimmune attack on the integrity of the central nervous system.

Case Studies in Immunology, Fifth Edition cites major topics of immunology as the background to a selection of real clinical cases that serve to reinforce and extend the basic science. This new edition vividly illustrates the importance of an understanding of immunology in diagnosis and therapy. As well as being a valuable review aid, Case Studies in Immunology introduces in a clinical setting the major common disorders of immunity, including hypersensitivity types I-IV and autoimmune disorders such as lupus and multiple sclerosis. It also describes and explains the consequences of some of the most important immune deficiencies. Each case history is preceded by basic scientific facts essential to understanding the immunology behind the disease or disorder. An end-of-case summary, questions, and discussion points finish each case. Case Studies in Immunology can be used as a stand-alone book, or as a clinical companion alongside Janeway's Immunobiology, Seventh Edition (ISBN 0-8153-4123-9) and The Immune System, Third Edition (ISBN 0-8153-4146-8).

This case study is about a 29-year-old professional oboe player who was first diagnosed for optic neuritis and then for multiple sclerosis (MS). MS is an example of a T-cell mediated autoimmune disease, wherein there is an autoimmune attack on the integrity of the central nervous system.

Case Studies in Immunology, Fifth Edition, cites major topics of immunology as the background to a selection of real clinical cases that serve to reinforce and extend the basic science. This new edition vividly illustrates the importance of an understanding of immunology in diagnosis and therapy. As well as being a valuable review aid, Case Studies in Immunology introduces in a clinical setting the major common disorders of immunity, including hypersensitivity types I-IV and autoimmune disorders such as lupus and multiple sclerosis. It also describes and explains the consequences of some of the most important immune deficiencies. Each case history is preceded by basic scientific facts essential to understanding the immunology behind the disease or disorder. An end-of-case summary, questions, and discussion points finish each case.

Mayo Clinic Cases in Neuroimmunology delivers a case-based walk-through of demyelinating, autoimmune, and other inflammatory neurologic disorders and their mimics. The authors present cases from their own extensive experience with common and rare neuroimmunologic disorders. The format of this case-based book was developed to stimulate consideration of the differential diagnosis as the reader reviews the history and examination narratives of each of the 83 cases. Videos of autoimmune movement disorders supplement the clinical descriptions, where pertinent. In addition, test results from radiology, electrophysiology, and laboratory studies are presented, and treatment and outcome data are also included. Clinical pearls and radiologic clues to assist informed diagnostic decision-making are emphasized. Each case is followed by discussion, including therapeutic guidance and key take-home points. More than 150 multiple-choice questions with answers are also given to test readers' comprehension and retention. This new addition to the Mayo Clinic Scientific Press series is a comprehensive volume on neuroimmunology that will stimulate and inform those aiming for clinical mastery.

This book presents case histories to illustrate in a clinical context essential points about the mechanisms of immunity. It includes cases that illustrate both recently discovered genetic immunodeficiencies and some more familiar and common diseases with interesting immunology.

Knowledge has been described as being like an expanding sphere with the volume of knowledge contacting a surface on the unknown. This new comprehensive review of the many fields of basic and clinical research that impact our understanding of multiple sclerosis has its basis in this premise. In doing research on MS, it is not enough to know clinical neurology or neurochemistry or neuroanatomy or pathology; it is important to understand the many other areas that relate to them. This volume provides an overview of MS-related research and will benefit many investigators in the field and help to advance our efforts to cure this, thus far intractable, disease. It is now more than 160 years since the first clinical-pathological descriptions of cases of multiple sclerosis and more than 130 years since the classic clinical description and development of diagnostic criteria by Charcot, yet MS remains an enigma. After decades of intense effort to find the cause, no cause has been clearly identified and the disease remains poorly understood. Despite the introduction of immunomodulatory therapies and immunosuppressive regimens, MS remains a devastating disease. While a great deal of progress has been made, much remains to be done. Our understanding of the disease remains limited, treatments remain inadequate, and comprehensive management all too rare. This volume is an overview of the basic sciences as they relate to MS and will provide clinicians and investigators a better understanding of the basic aspects of the disease. While it is possible to find excellent reviews of almost any aspect of MS, few attempts have been made to bring these very different aspects together in a single source. This volume is a companion to Multiple Sclerosis: Diagnosis, Medical Management, and Rehabilitation, edited by Drs. Jack S. Burks and Kenneth P. Johnson. Together, they represent an attempt to comprehensively cover the field of MS from basic research to comprehensive management and to provide a broad overview for those interested in understanding the disease better or in pursuing MS research.