This issue of Cardiac Electrophysiology Clinics, edited by Drs. Mohammad Shenasa and Stanley Nattel, will review Cardiac Potassium Channel Disorders in depth. Topics covered include but are not limited to: Molecular Biology of Cardiac Potassium Channels; Genetic Control of Potassium Channels; Potassium Channel Remodeling in Heart Disease; Gender-specific Effects of Potassium Channel Blockers; Pharmacogenetics of Potassium Channel Blockers; Multichannel Blockers; Selective Potassium Channel Blockers; and Proarrhythmic and Torsadogenic Effects of Potassium Channel Blockers in Patients.

The sodium channel, a ubiquitous member of the cardiac, neural, and muscular conduction systems, has been implicated in the pathogenesis of an array of human diseases. Mutations associated with the cardiac sodium channel are responsible for a wide spectrum of disorders. The cardiac sodium channel and associated disorders are comprehensively examined in this issues of the Cardiac Electrophysiology Clinics.

This issue of the Cardiac Electrophysiology Clinics, edited by Drs. Amin Al- Ahmad and Francis Marchlinski, will cover Ventricular Tachycardia in Structural Heart Disease. Topics discussed in the issue include, but are not limited to, ECG localization of VT in patients with structural heart disease; Anatomy for VT ablation in structural heart disease; Ablation of VT in ischemic and non-ischemic heart disease; Pace mapping; Ablation of VT in ARVD; Epicardial VT ablation; and VT clinical trials, among others.

Long QT syndrome is a heart rhythm disorder that can cause fast, chaotic heartbeats. In some cases, long QT syndrome can cause sudden death. Long QT syndrome may result from a genetic mutation or be caused by certain medications and medical conditions. The condition is treatable with medication, surgery, or an implantable device. Because it may have serious consequences, it's important for electrophysiologists to know about long QT syndrome.

This issue of the Cardiac Electrophysiology Clinics entitled “Ventricular Arrhythmias in Apparently Normal Hearts is being edited by Drs. Frank M. Bogun, Thomas Crawford, and Rakesh Latchamsetty. The issue will cover topics including, the mechanisms of ventricular arrhythmias, the role of genetic testing, papillary muscle arrhythmias, fascicular arrhythmias, exercised induced VT, VF, and SCD in the normal heart, and various management techniques.

Controversies in Cardiac Electrophysiology are examined in this issue of Cardiac Electrophysiology Clinics. Difficult cases are presented and esteemed leaders in the field debate the pros and cons of various forms of management and treatment.

This issue of the Cardiac Electrophysiology, edited by Dr. Masood Akhtar, will cover the physiological and pathological aspects of the His-Purkinje System in depth. This content will be supported by a variety of clinical cases that explore various aspects of and issues encountered involving the His-Purkinje System compliment the pathology and physiology.