Selected papers from the Third Hans Wolfgang Nurnberg Memorial Workshop on Toxic Metal Compounds, Follinica, Italy, April 1988. The workshop discussed the gaps between chemistry and biology, and the topics covered include: the analytical chemistry and speciation of air particulates, water, sediments, soils, and of food and tissue; uptake by plants, mosses, and lichens, including biomonitoring techniques; and the uptake and biological effects of chromium, nickel, cadmium, and aluminum compounds. the papers were first published in issues of Toxicological and environmental chemistry and International journal of environmental analytical chemistry. Annotation copyrighted by Book News, Inc., Portland, OR

This book contains selected papers presented at the Third Hans Wolfgang Nurnberg Memorial Workshop on Toxic Metal compounds held in Follinica, Italy in April 1988. This workship discussed the areas of research which link chemistry and biology, difining real problems for further research, and was attended by experts from different fields including analytical chemistry, speciation, environmental chemistry, biochemistry, short-term testing and risk assessment.

Environmental pollution is one of the main problems to confront humanity, with the heavy metals occupying a leading role among the most pernicious pollutants. The metals cause cancer and other sicknesses. Their cytotoxic, mutagenic and carcinogenic potentials are not fully understood, and any thorough investigation demands the combined efforts of scientists drawn from many different disciplines. But the effects of heavy metals are not all negative: some, like cis-DDP, and some ruthenium and tin complexes, have antitumour activity. The idea underlying the present work is therefore to present a multidisciplinary perspective on heavy metals in the environment, affording a better understanding of their action on human organisms and health, aiming to make them less polluting and more environmentally friendly.

Selected papers from the Third Hans Wolfgang Nurnberg Memorial Workshop on Toxic Metal Compounds, Follinica, Italy, April 1988. The workshop discussed the gaps between chemistry and biology, and the topics covered include: the analytical chemistry and speciation of air particulates, water, sediments, soils, and of food and tissue; uptake by plants, mosses, and lichens, including biomonitoring techniques; and the uptake and biological effects of chromium, nickel, cadmium, and aluminum compounds. the papers were first published in issues of Toxicological and environmental chemistry and International journal of environmental analytical chemistry. Annotation copyrighted by Book News, Inc., Portland, OR

but also the possibility of intervention in specific stages. In Human behavior, including stress and other factors, plays an important role in neoplasia, although too little is known addition, variables which affect cancer development as well on the reasons for such development. Carcinogens, which as some endogenous factors can be better delineated help initiate the neoplastic process, may be either synthetic through such investigations. The topics of this volume encompass premalignant non or naturally-occurring. Cancer causation may be ascribed to invasive lesions, species-specific aspects of carcinogenicity, certain chemicals, physical agents, radioactive materials, viruses, parasites, the genetic make-up of the organism, and radiation, viruses, a quantum theory of carinogenesis, onco bacteria. Humans, eumetazoan animals and vascular plants genes, and selected environmental carcinogens. are susceptible to the first six groups of cancer causes, whe reas the last group, bacteria, seems to affect only vascular plants. Neoplastic development may begin with impairment ofJmdy defenses by a toxic material (carcinogen) which acts as an initiator, followed by promotion and progression to an overt neoplastic state. Investigation of these processes Series Editor Volume Editor allows not only a better insight into the mechanism of action Hans E. Kaiser Elizabeth K. Weisburger vii ACKNOWLEDGEMENT Inspiration and encouragement for this wide ranging project on cancer distribution and dissemination from a comparative biological and clinical point of view, was given by my late friend E. H. Krokowski.