In this issue of Hematology/Oncology Clinics, guest editor Dr. Elizabeth K. O'Donnell brings her considerable expertise to the topic of Cancer Precursor Syndromes and Their Detection. Top experts focus on cancer precursors for different sites, with articles on the risk-benefit analysis of early interception; plasma cell precursors; early detection and interception of lung cancer, cervical cancer, GI cancers, skin cancer; and head and neck cancer; biomarkers and early detection; and more. - Contains 12 relevant, practice-oriented topics including clonal hematopoiesis of indeterminate potential (CHIP); prostate cancer: early detection and intervention; ductal carcinoma in situ; cancer prevention; and more. - Provides in-depth clinical reviews on cancer precursor syndromes and their detection, offering actionable insights for clinical practice. - Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.

In this issue of Hematology/Oncology Clinics, guest editor Dr. Elizabeth K. O'Donnell brings her considerable expertise to the topic of Cancer Precursor Syndromes and Their Detection. Top experts focus on cancer precursors for different sites, with articles on the risk-benefit analysis of early interception; plasma cell precursors; early detection and interception of lung cancer, cervical cancer, GI cancers, skin cancer; and head and neck cancer; biomarkers and early detection; and more. Contains 12 relevant, practice-oriented topics including clonal hematopoiesis of indeterminate potential (CHIP); prostate cancer: early detection and intervention; ductal carcinoma in situ; cancer prevention; and more. Provides in-depth clinical reviews on cancer precursor syndromes and their detection, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.

Topics include: Targeting IGF-1R, Tyrosine Kinase Inhibitors in Lung Cancer, Targeting mTOR, Targeting Hedgehog, Mitotic Inhibitors, Topoisomerase I Inhibitors , and New Strategies and Drugs Inhibiting Folate Pathways.

This issue serves as a timely review of both the genetic and genomic factors resulting in a predisposition to human cancer. There is now strong evidence to support the use of genetic testing for cancer predisposition in the practice of preventive medicine, and at the same time, there is emerging new literature defining the role of genomic approaches to assessment of cancer predisposition. Articles address predisposition syndromes in the areas of breast cancer, lower GI cancer, genitourinary cancer, pediatric cancer, endocrine cancer, and hematologic malignancy.

In this issue of Hematology/Oncology Clinics, guest editor Dr. David E. Fisher brings his considerable expertise to the topic of Cutaneous Oncology. Top experts first provide information on skin structure, function, and immunology, then offer overviews of the therapeutic state of the art for both melanoma and non-melanoma skin cancers. Discussions focus on unique clinical challenges and biological breakthroughs which have come to light in recent studies of cutaneous malignancies. - Contains 16 relevant, practice-oriented topics including high risk non-melanoma skin cancers; progress in immune checkpoints for melanoma therapy; targeted therapy innovations for melanoma; advances in vaccines for melanoma; microbiome and immunotherapy; Merkel cell carcinoma; and more. - Provides in-depth clinical reviews on cutaneous oncology, offering actionable insights for clinical practice. - Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.

In this issue of Hematology/Oncology Clinics, guest editors Drs. Kimmie Ng and Benjamin L. Schlechter bring their considerable expertise to the topic of Colorectal Cancer. Despite tremendous progress in the management of this disease, many questions and controversies remain regarding screening, adjuvant therapy for resected colon cancers, targeted therapies and immunotherapy for patients with advanced disease, surgical management, and more. In this issue, top experts in the field address provide clinicians with the tools to individualize management and optimize care for this growing patient population. - Contains 13 relevant, practice-oriented topics including screening for colorectal cancer; hereditary colorectal cancer; disparities in colorectal cancer; microbiome in colorectal cancer; impact of diet and exercise on colorectal cancer; colorectal cancer in younger adults; and more. - Provides in-depth clinical reviews on colorectal cancer, offering actionable insights for clinical practice. - Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.

This issue of Hematology/Oncology Clinics, guest edited by Patrick A. Ott, will focus on Immunotherapy in Cancer. Topics include, but are not limited to, Cancer Vaccines, Innate Immune stimulation, Costimulatory and Agonistic Antibodies, Immune modulation with radiation, Oncolytic virus therapy, Cytokine Therapy, Adoptive T cell transfer, Immune related toxicity, and Immune checkpoint combinations.