This book is devoted to the description of agenesis of the corpus callosum, a congenital malformation of midline structures in the brain that may be regarded as a natural model of the "split-brain. " First reported by Rei! in 1812, this anomaly has since been described by several investigators. Interest in this malformation was revived in the 1970s by studies of interhemispheric transfer in Bogen and Vogel's commissurotomized patients and the subsequent findings by Sperry that acallosal patients were devoid of the typical disconnection deficits found in patients with surgical transection of the corpus callosum. Since this seminal work, the bulk of neuropsychological research on callosal agenesis has focused on the particulars of interhemispheric transfer and integration. An ever-growing literature has emerged on the subject, attempting to specify the extent and limits of neural plasticity in a nervous system that has evolved in the absence of the most important interhemispheric pathway. Whilst callosal agenesis proves to be an excellent model of cerebral plasticity, it has to be pointed out that this anomaly is often associated with other malformations and neurological diseases that may result in different degrees of mental retardation or other cognitive and sensorimotor deficits. In this context, neurological research on callosal agenesis has concentrated on the description of various syndromes associated with this pathology as well as on the attempt to specify its neurobehavioral manifestations.

This book has brought together leading investigators who work in the new arena of brain connectomics. This includes ‘macro-connectome’ efforts to comprehensively chart long-distance pathways and functional networks; ‘micro-connectome’ efforts to identify every neuron, axon, dendrite, synapse, and glial process within restricted brain regions; and ‘meso-connectome’ efforts to systematically map both local and long-distance connections using anatomical tracers. This book highlights cutting-edge methods that can accelerate progress in elucidating static ‘hard-wired’ circuits of the brain as well as dynamic interactions that are vital for brain function. The power of connectomic approaches in characterizing abnormal circuits in the many brain disorders that afflict humankind is considered. Experts in computational neuroscience and network theory provide perspectives needed for synthesizing across different scales in space and time. Altogether, this book provides an integrated view of the challenges and opportunities in deciphering brain circuits in health and disease.

Atlas of Clinical Neurology, by David Perkin, Douglas C. Miller, Russell Lane, Maneesh C. Patel, and Fred H. Hochberg, delivers the most powerful, clinically oriented image collection of any reference in your specialty - to help you accurately diagnose any condition you see in practice! Approximately 2,000 large, high-quality images – 1,000 in full color - capture the characteristic physical examination and imaging findings of every type of neurological disorder. All of the diagnostic imaging studies have been updated to reflect the dramatic advances in neuroimaging. Updates throughout include a brand-new chapter on myopathies and myasthenia, expanded coverage of epilepsy, and an entire chapter devoted to extrapyramidal disorders. The result is the ultimate diagnostic resource in neurology! Find a perfect match for your clinical findings with the aid of the most powerful, clinically oriented image collection found in any neurology atlas: 2,000 illustrations, 1,000 in full color! Interpret the findings from the latest neuroimaging techniques with the aid of thoroughly updated images representing the most recent advances. Effectively overcome difficult diagnostic challenges with a brand-new chapter on myopathies and myasthenia, expanded coverage of epilepsy, and an entire chapter devoted to extrapyramidal disorders.

"What is autism and Asperger syndrome? What are the core symptoms, and what causes them? How early can autism be recognised and what can be done? Why does autism seem to be more and more common? Are we all a little bit autistic?" "This Very Short Introduction offers a clear statement on what is currently known about autism and Asperger syndrome. Looking at symptoms from the full spectrum of autistic disorders, and evaluating current evidence from neuroscience and genetics, this authoritative and accessible book explores the source and nature of social impairment and exceptional talent. Autism: A Very Short Introduction gives a glimpse of life seen through the eyes of autism."--BOOK JACKET.

Pediatric Neuroophthalmology details the diagnostic criteria, current concepts of pathogenesis, neuroradiological correlates, and clinical management of a large group of neuroophthalmic disorders that present in childhood. Surprisingly distinct from neuroophthalmic disorders afflicting adults, this set of diseases falls between the cracks of most ophthalmology training, and thus, warrants a practical, clinical guide for the practitioner in ophthalmology - the neuroophthalmologist, pediatric ophthalmologist, general ophthalmologist - as well as neurologists and for residents. The authors, leading pediatric ophthalmologists, have taken this difficult subject matter and developed an accessible, user-friendly manual with a detailed approach to the recognition, differential diagnosis, and management of pediatric neuroophthalmologic disorders.

Research on brain asymmetry, with particular emphasis on findings made possible by recent advances in neuroimaging.