Find your drive and redefine your business priorities Breakpoints is the business owner's guide to regaining your passion and driving your business forward. If you're feeling stuck, stale or stalled, this book is your ticket out of the rut and into profitable growth. You'll learn the 7 Mistakes Business Owners Make, and identify the choices, behaviours and practices that are keeping your business in a holding pattern. Practical formulas, frameworks, strategies and tools get you started right away on refocusing and reprioritising, and taking back your life. Coverage includes both hard and soft topics that business owners frequently struggle to master, along with expert insight on execution and what lies beyond success. Written simply and directly, without jargon or acronyms, this no-nonsense guide is designed to be easy to read and easy to apply so you can get back to work quickly, inspired with a whole new outlook and equipped with practical tools to improve your business. Written in a style that is both conversational and entertaining, author Dr Mike Ashby offers numerous anecdotes and analogies drawn from working with hundreds of business owners. Owning a business can be exciting and terrifying at the same time. There's too much to do, and all accountability leads to you. If you've gotten hung up in the day-to-day running of your business, this book helps you regain sight of the big picture and get back on track to success. Learn what's holding you back from business success Adopt the tools and practices that end the stalemate and get things done Find clarity and focus, and reconnect with your business Leverage your strengths to achieve personal and business growth Business owners need to be well-versed in both strategy and execution. If you feel like you and your business have reached a plateau, Breakpoints will reignite the spark that drives business success.

An insightful look at the American environmental crisis and emerging solutions from the heartland to the coasts in the era of global climate change Eminent ecologist Jeremy B. C. Jackson and award-winning journalist Steve Chapple traveled the length of the Mississippi River interviewing farmers, fishermen, scientists, and policymakers to better understand the mounting environmental problems ravaging the United States. Along their journey, which quickly expands to California, Florida, and New York, the pair uncovered surprising and profound connections between ecological systems and environmental crises across the country. Artfully weaving together independent research and engaging storytelling, Jackson and Chapple examine the looming threats from recent hurricanes and fires, industrial agriculture, river mismanagement, extreme weather events, drought, and rising sea levels that are pushing the country toward the breaking point of ecological and economic collapse. Yet, despite these challenges, the authors provide optimistic and practical solutions for addressing these multidimensional issues to achieve greater environmental stability, human well-being, and future economic prosperity. With a passionate call to action, they look hopefully toward emerging and achievable solutions to preserve the country's future.

Visual Studio 2013 is one of the most sophisticated integrated development environments in the world today. With hundreds of features and several different editions available, it can be hard to learn your way around, and hard to know whether you're using it to its full potential. Visual Studio Condensed gives you a quick and systematic guide to the features that matter most, tagged clearly according to their availability. The book starts by familiarizing you with the main features of Visual Studio and how to configure the user interface depending on your needs. You'll then dive into each key developer tool in turn, starting with the editor window and going through the navigation pane, documentation, and the NuGet package manager. Debugging is a difficult skill to master with a range of approaches and tools at your disposal, so you'll see how to make best use of breakpoints, the debugging windows, tracing and managed memory analysis, as well as tips and tricks on advanced debugging techniques that can make a real difference to your productivity. Visual Studio 2013 comes with sophisticated code improvement tools. You can visualize relationships in your code with the Code Map feature, find duplicated code to maximize your code reuse, and use Visual Studio's inbuilt list of metrics to figure out just how healthy your code is and how difficult or easy it will be to maintain. Testing is also made easy with unit testing and web performance tests as well as a Test Manager to organize your tests into test plans and suites. The final chapters of the book cover team work with Team Foundation Server, framework-specific features, and how to build your own Visual Studio extensions. Visual Studio Condensed is the ideal manual for busy developers who just want to get on with what matters: writing code. Whether you're new to Visual Studio or brushing up on the latest features, this book will get you up to speed in no time.

Skip the basics and delve right into Visual Studio 2017 advanced features and tools Professional Visual Studio 2017 is the industry-favorite guide to getting the most out of Microsoft's primary programming technology. From touring the new UI to exploiting advanced functionality, this book is designed to help professional developers become more productive. A unique IDE-centric approach provides a clear path through the typical workflow while exploring the nooks and crannies that can make your job easier. Visual Studio 2017 includes a host of features aimed at improving developer productivity and UI, and this book covers them all with clear explanation, new figures, and expert insight. Whether you're new to VS or just upgrading, this all-inclusive guide is an essential resource to keep within arm's reach. Visual Studio 2017 fixes the crucial issues that kept professionals from adopting VS 2015, and includes new features and tools that streamline the developer's job. This book provides the straightforward answers you need so you can get up to speed quickly and get back to work. Master the core functionality of Visual Studio 2017 Dig into the tools that make writing code easier Tailor the environment to your workflow, not the other way around Work your way through configuration, debugging, building, deployment, customizing, and more Microsoft is changing their release cadence—it's only been about two years since the last release—so developers need to quickly get a handle on new tools and features if they hope to remain productive. The 2017 release is designed specifically to help you get more done, in less time, with greater accuracy and attention to detail. If you're ready to get acquainted, Professional Visual Studio 2017 is your ideal guide.

Dirk is a graduate Civil Engineer from the Mackenzie University (Sao Paulo, Brazil) and Automobile Engineer from the General Motors Institute - GMI (Flint, Michigan - USA) and has specialized courses on Psychology, Human Relations, Human Development, Marketing, Business Strategy and Business Administration from Brazil and abroad. In his executive career in the Automotive and Railway industries in Brazil, he was Director of Product Engineering and Quality Control of Chrysler Brazil. He was also head of the Product and Marketing Committees for Chrysler Brazil and Argentina. Dirk was President of Fresinbra Industrial S.A., the Brazilian subsidiary of Westinghouse Airbrakes / American Standard Co. and was simultaneously Director of all the other American Standard Corp. companies in Brazil. At this time he was, by invitation, a member of the Young Presidents Club (Paris, France), which is exclusive for large company Presidents under 40 years of age. In 1982 he was the founder and only President of DM-PRODUTIVISMO S/C LTDA. a consulting firm specializing in Value Analysis and Value Engineering, business development, competitiveness, quality and management techniques. During this period, Dirk had as clients many of the largest companies in Brazil (the 100 largest of Exame Magazine), and was Member of the Council for industries, hospitals and commerce companies. Among his international clients, Dirk consulted for Leighton Contractors (Asia) in Hong Kong and for John Holland Group, in Camberra and Sidney, Australia. Dirk was responsible for the introduction of new techniques in Brazil like Value Analysis and Engineering and the Theory of Constraints, and developed successful new productivity, quality and competitiveness techniques, implemented with impressive results in companies in Brazil, China and Australia. Dirk published articles on Management in the U.S.A., Europe, Japan, China and several Latin American countries. He was awarded in 1988 by SAVE International the Value Engineering Merit Award and in 1997 with a Special Recognition Award by SJVE - The Society of Japanese Value. He was also merit awarded by several Universities in Brazil, Argentina and Chile.

BUS000000

This volume provides practical guidance on a variety of techniques and steps to ensure successful variant calling. Chapters detail methods for variant calling from single-nucleotide variants to structural variants, variant calling in specialized data types such as RNA-seq and UMI-tagged sequencing, alignment-free genotyping and SNP calling, variant detection in single-cell DNA sequencing data, variant annotation, and preanalytical quality control to ensure successful variant calling. Written in the format of the highly successful Methods in Molecular Biology series, each chapter includes an introduction to the topic, lists step-by-step protocol to execute the algorithms, describes the input and output data, and includes tips on troubleshooting and known pitfalls. Authoritative and cutting-edge, Variant Calling: Methods and Protocols aims to be a foundation for future studies and to be a source of inspiration for new investigations in the field.