This is the first volume in a 2-volume compendium that is the go-to source for both research- and practice-oriented information on the importance of branched chain amino acids in maintaining the nutritional status and overall health of individuals, especially those with certain disease conditions. Over 150 well recognized and respected contributors have come together to compile these up-to-date and well-referenced works. The volumes will serve the reader as the benchmarks in this complex area of interrelationships between dietary protein intakes and individual amino acid supplementation, the unique role of the branched chain amino acids in the synthesis of brain neurotransmitters, collagen formation, insulin and glucose modulation and the functioning of all organ systems that are involved in the maintenance of the body’s metabolic integrity. Moreover, the physiological, genetic and pathological interactions between plasma levels of branched chain amino acids and aromatic amino acids are clearly delineated so that students as well as practitioners can better understand the complexities of these interactions. Branched Chain Amino Acids in Clinical Nutrition: Volume 1 covers basic processes at the cellular level, inherited defects in branched chain amino acid metabolism, and experimental models of growth and disease states.

This is the second volume in a 2-volume compendium that is the go-to source for both research- and practice-oriented information on the importance of branched chain amino acids in maintaining the nutritional status and overall health of individuals, especially those with certain disease conditions. Over 150 well recognized and respected contributors have come together to compile these up-to-date and well-referenced works. The volumes will serve the reader as the benchmarks in this complex area of interrelationships between dietary protein intakes and individual amino acid supplementation, the unique role of the branched chain amino acids in the synthesis of brain neurotransmitters, collagen formation, insulin and glucose modulation and the functioning of all organ systems that are involved in the maintenance of the body’s metabolic integrity. Moreover, the physiological, genetic and pathological interactions between plasma levels of branched chain amino acids and aromatic amino acids are clearly delineated so that students as well as practitioners can better understand the complexities of these interactions. Branched Chain Amino Acids in Clinical Nutrition: Volume 2 covers the role of branched chain amino acids in healthy individuals, and branched chain amino acid status in disease states, liver diseases, and supplementation studies in certain patient populations.

Traumatic brain injury (TBI) accounts for up to one-third of combat-related injuries in Iraq and Afghanistan, according to some estimates. TBI is also a major problem among civilians, especially those who engage in certain sports. At the request of the Department of Defense, the IOM examined the potential role of nutrition in the treatment of and resilience against TBI.

The first edition of this innovative book brought a new perspective to the metabolic and therapeutic aspects of amino acids in clinical nutrition. Since its publication, a number of very important advances have been made in the field and interesting new findings have emerged. Until now, no reference has fully explored the promising new developments

The branched-chain amino acids are unique in chemical structure, metabolism, and that they are essential in the diet of both humans and monogastric food animals. Whether you are a health professional looking to increase your Knowledge of amino acid nutrition on disease, health, and aging, or an agriculture scientists looking to broaden your knowledge of factors influencing amino acid requirements, this text is a must.This book represents three diverse sections encompassing eleven chapters in total. Section one, being the largest, consist of six chapters addressing the role of branched-chain amino acids in domestic animal and human health. Endocrine and antioxidant systems affected by branched-chain amino acid status are presented, as well as biochemical and molecular mechanisms behind their responses. Moreover, the pros and cons of branched-chain amino acid therapy and balance in sports nutrition, catabolic injury recovery, disease, and successful aging are presented.The second and third sections of this text are similarly unique, in that they contain five chapters addressing diet needs, digestion, intestinal metabolism, absorption, and subsequent whole-body metabolism at the biochemical and molecular level. Further, two different meta-analyses have been composed using independent branched-chain amino acid data for assessment of food animal needs, in addition to providing insights for controlling metabolic homeostasis via diet formulation. Lastly, and specific for food animal production, the most limiting branched-chain amino acids in swine and poultry diets (e.g., valine and isoleucine) are poised to gain popularity and further price competitiveness in their crystalline L-amino acid forms, and thus, have tremendous environmental implications in terms of planetary nitrogen and water cycling.