From the first time that I painted, I had no interest to be a derivative of other artists. My driving intuition was to be influenced nonconsciously by brain insights. My privileged view of the brain, is of overseeing the data patterns of human brain function in the world’s largest brain database. My art is mainly abstract expressionism that reflects my understanding of how the human brain and behavior works. Each series of paintings continue for a few months and are driven by a different inspiration from the nonconscious-conscious dynamics of my brain. The last series in this book: “Unbridled” – is where my nonconscious brain most dominated whatever spontaneously emerged (with no preconceptions) ‘in the moment’, in each painting. I am indebted to the wide influences from my background in brain science, medicine and the international brain database that I set up. As well as the feedback and inspirations from true friends (and attendees at my exhibitions, including 2 exhibitions in New York). Further details and contact information is on the website: http://www.BRAINSightArt.com

The development of new CNS drugs is notoriously difficult. Drugs must reach CNS target sites for action and these sites are protected by a number of barriers, the most important being the blood–brain barrier (BBB). Many factors are therefore critical to consider for CNS drug delivery, e.g. active/passive transport across the BBB, intra-brain distribution, and central/systemic pharmacokinetics, to name a few. Neurological disease and trauma conditions add further complexity because CNS barriers, drug distribution and pharmacokinetics are dynamic and often changed by disease/trauma. Knowledge of all these factors and their interplay in different conditions is of utmost importance for proper CNS drug development and disease treatment. In recent years much information has become available for a better understanding of the many factors important for CNS drug delivery and how they interact to affect drug action. This book describes small and large drug delivery to the brain with an emphasis on the physiology of the BBB and the principles and concepts for drug delivery across the BBB and distribution within the brain. It contains methods descriptions for studying drug delivery, routes and approaches of administering drugs into the brain, the influence of disease, drug industry perspectives, and a primer on neuroanatomy and physiological considerations written specifically for drug delivery scientists. Therewith, it contributes to an in-depth understanding of the interplay between brain (patho)-physiology and drug characteristics. Furthermore, the content is designed to be both cutting-edge and educational, so that the book can be used in high-level training of academic and industry scientists with full references to original publications.

Since becoming commercially available in 1985, transcranial magnetic stimulation (TMS) has emerged as an important tool in several areas of neuroscience. Originally envisioned as a way to measure the responsiveness and conduction speed of neurons and synapses in the brain and spinal cord, TMS has also become an important tool for changing the activity of brain neurons and the functions they subserve and an important adjunct to brain imaging and mapping techniques. Along with transcranial electrical stimulation techniques, TMS has diffused far beyond the borders of clinical neurophysiology and into cognitive, perceptual, behavioural, and therapeutic investigation and attracted a highly diverse group of users and would-be users. This book provides an authoritative review of the scientific and technical background required to understand transcranial stimulation techniques and a wide-ranging survey of their burgeoning application in neurophysiology, perception, cognition, emotion, and clinical practice. Each of its six sections deals with a major area and is edited by an international authority therein. It will serve researchers, clinicians, students, and others as the definitive text in this area for years to come.

Numerous publications have attested to the therapeutic efficacy of non-invasive brain stimulation (NIBS) techniques, such as repetitive transcranial magnetic stimulation (rTMS) and low-intensity transcranial electrical stimulation (tES). These methods have been used in the treatment of various neurological-related conditions, such as chronic pain, cognitive disorders, movement disorders, or stroke rehabilitation. Across these different fields, evidence suggests therapeutic efficacy could be improved when combining NIBS technique in combination with another type of more commonly utilized therapeutic approaches (e.g., motor and/or cognitive training, pharmacological, physical and neurorehabilitation).

The papers in this volume consider the role of sensory-motor processes and their neural structures in higher cognitive functions such as visual and motor imagery, iconic memory and temporal judgment. The evidence brought to bear on this issue comes from behavioral studies of brain-damaged subjects and fMRI and TMS studies with normal subjects. The issue also includes several theoretical reviews and discussions.

Current Techniques in Canine and Feline Neurosurgery offers state-of-the-art, detailed guidance on performing neurosurgical techniques in dogs and cats, from indications and surgical anatomy to procedures and post-operative care. Presents an up-to-date, detailed reference on veterinary neurosurgery techniques, covering skills ranging from basic to advanced Provides guidance on why, when, and how to perform neurosurgical procedures Includes information on diagnostic evaluation, surgical planning, and instrumentation as well as step-by-step descriptions of specific procedures Copublished with the American College of Veterinary Surgeons Foundation and American College of Veterinary Internal Medicine Offers video clips on a companion website

There are many resources on grant writing in science, technology and medicine, but most do not provide the practical advice needed to write the narratives of grant proposals. Designed to help novice and experienced investigators write compelling narratives and acquire research funding, this is a detailed guide to the content, organisation, layout, phrasing, and scientific argumentation of narratives. The authors draw on more than twenty years of research and analysis of grant proposals, having worked extensively with investigators at different levels, from pre-doctoral students to senior scientists. They have used this experience to design a framework for scientific writing that you can apply directly to narratives. The guidelines and advice offered are applicable across many funding agencies, including the NIH and NSF. Featuring many real-life examples, the book covers a range of topics, from organisational alternatives to best practices in grammar and editing, overview visuals, and working with contributors.