This book provides an essential overview of the broad range of functional brain imaging techniques, as well as neuroscientific methods suitable for various scientific tasks in fundamental and clinical neuroscience. It also shares information on novel methods in computational neuroscience, mathematical algorithms, image processing, and applications to neuroscience. The mammalian brain is a huge and complex network that consists of billions of neural and glial cells. Decoding how information is represented and processed by this neural network requires the ability to monitor the dynamics of large numbers of neurons at high temporal and spatial resolution over a large part of the brain. Functional brain optical imaging has seen more than thirty years of intensive development. Current light-using methods provide good sensitivity to functional changes through intrinsic contrast and are rapidly exploiting the growing availability of exogenous fluorescence probes. In addition, various types of functional brain optical imaging are now being used to reveal the brain’s microanatomy and physiology.

A broad overview of neuroimaging offering reputable, foundational content for researchers and students across the biological and medical sciences.

Comprehensive resource features state-of-the-art brain mapping techniques and pearls from international recognized neurosurgeons Alfredo Quinones-Hinojosa and Kaisorn Chaichana and coeditor Deependra Mahato Despite advances in imaging techniques to identify eloquent cortical brain regions and subcortical white matter, brain mapping is the only method for obtaining real-time information with high sensitivity and specificity. This groundbreaking technology greatly enhances the neurosurgeon's ability to safely resect challenging lesions located in eloquent areas of the brain. Brain Mapping: Indications and Techniques by esteemed neurosurgeons Alfredo Quinones-Hinojosa, Kaisorn Chaichana, and Deependra Mahato, is a comprehensive overview of the most critical aspects of brain mapping from leaders in the field. The book starts with discussion of preoperative aspects, including the history of brain mapping and anatomy of eloquent cortical and eloquent white matter tracts. Subsequent chapters cover perioperative aspects of brain mapping including indirect and direct functional mapping, the role of neurophysiology, awake craniotomy operating room set-up and surgical instruments, and anesthetic considerations. Diverse awake and asleep brain mapping techniques are described for various intracranial pathologies, as well as advances in postoperative recovery of neurological function including physical and speech therapy. Key Features Dedicated chapters focused on essential sensory functions cover speech mapping, asleep motor mapping, awake subcortical language mapping, and visual cortex and visual tract mapping Disease- and region-specific techniques that encompass extra-operative brain mapping for epilepsy, surgery mapping for insular tumors, seizure mapping, and brainstem and spinal cord mapping Clinical pearls on postoperative issues such as rehabilitation, emergence of DBS-evoked functional connectomics, brain neuroplasticity, and radiating eloquent areas High-quality illustrations and videos enhance understanding of brain regions targeted in different mapping techniques This is the most comprehensive resource available to date on brain mapping and surgery in eloquent regions. As such, it is a must-have for neurosurgical residents, fellows, practicing neurosurgeons, and allied healthcare practitioners who treat patients with brain conditions.

Significant advances in brain research have been made, but investigators who face the resulting explosion of data need new methods to integrate the pieces of the "brain puzzle." Based on the expertise of more than 100 neuroscientists and computer specialists, this new volume examines how computer technology can meet that need. Featuring outstanding color photography, the book presents an overview of the complexity of brain research, which covers the spectrum from human behavior to genetic mechanisms. Advances in vision, substance abuse, pain, and schizophrenia are highlighted. The committee explores the potential benefits of computer graphics, database systems, and communications networks in neuroscience and reviews the available technology. Recommendations center on a proposed Brain Mapping Initiative, with an agenda for implementation and a look at issues such as privacy and accessibility.

This updated second edition provides the state of the art perspective of the theory, practice and application of modern non-invasive imaging methods employed in exploring the structural and functional architecture of the normal and diseased human brain. Like the successful first edition, it is written by members of the Functional Imaging Laboratory - the Wellcome Trust funded London lab that has contributed much to the development of brain imaging methods and their application in the last decade. This book should excite and intrigue anyone interested in the new facts about the brain gained from neuroimaging and also those who wish to participate in this area of brain science.* Represents an almost entirely new book from 1st edition, covering the rapid advances in methods and in understanding of how human brains are organized* Reviews major advances in cognition, perception, emotion and action* Introduces novel experimental designs and analytical techniques made possible with fMRI, including event-related designs and non-linear analysis

Imaging procedures have been used for many years and are becoming increasingly important in a number of medical disciplines. This is due to recent technological advances, primarily computerization. The meth ods employed in CNS diagnostics are collectively referred to as "neu roimaging" and include procedures for investigating both cerebral morphology and cerebral function, such as computed tomography (CT), magnetic resonance imaging (MRI), positron emission tomogra phy (PET), and single-photon emission computed tomography (SPECT). Topographic mapping of electroencephalograms (EEG) and evoked potentials represents one of the functional procedures and per mits topographic imaging of EEG, evoked potentials, and magnetic fields. The latter application includes not only magnetic fields evoked by stimuli relating to different sensory modalities, but also endogenous and motor fields resulting from spontaneous brain magnetic activity, as recorded by magnetoencephalograms (MEG), the magnetic comple ment of the EEG. The advantage of recording electric and magnetic fields over other neuroimaging procedures is that these techniques are completely noninvasive and have extremely short analysis times (in the millisecond range). The aim of this book is to clarify the current state of this emerging technology, to assess its potential for substantive contributions to brain research, to delineate areas for further research and, over all, to envis age clinical applications in disciplines such as psychiatry, neurology, and neuropsychology.

The field of neuroimaging has reached a watershed and critiques and emerging trends are raising foundational issues of methodology, measurement, and theory. Here, scholars reexamine these issues and explore controversies that have arisen in cognitive science, cognitive neuroscience, computer science, and signal processing.