How Far Would You Go to Survive? Maintenance supervisor Brian Francisco goes to sleep for the night in his Midwest apartment and wakes to find himself a prisoner aboard an oil tanker at sea. His predicament turns desperate when he learns of his captors’ intent to eventually kill him. With no clues to the reason for his capture, Francisco has only his ingenuity to fashion an escape. But even if he can manage to break out of the brig, he faces a bigger problem: how to flee a ship in the middle of the ocean. The former soldier must summon all his resources in a desperate bid to outwit the ship’s crew as well as the band of cutthroat mercenaries responsible for his abduction. Along the way, he struggles to maintain his humanity…and discover the sinister reason for his capture.

Lissa finds herself in demand by the Vampire Aristocracy. Forced into an unexpected engagement as a result, Lissa feels trapped and stifled as she continues training with her surrogate sire. When a request comes from the Grand Master of the werewolves, Weldon Harper, Lissa leaps at the opportunity to work as his bodyguard once more. Wlodek, Head of the Vampire Council, in an effort to solidify vampire/werewolf relations, allows Lissa to provide protection for the Grand Master during his yearly travels across the U.S. The only vampire ever named Pack, Lissa is permitted to work with the Grand Master without supervision from others of her kind. Things become complicated and then downright deadly as old enemies reemerge. Intent on exacting revenge for a failed coup against the Grand Master, rogue werewolves join with new and perilous allies. Now, Lissa must find a way not only to keep the werewolf race alive, but the vampires as well.

Blood Passage is the electrifying second book in the Dark Caravan Cycle—a modern jinni fantasy-adventure trilogy from author Heather Demetrios, perfect for fans of Laini Taylor's Daughter of Smoke and Bone series and Leigh Bardugo's Grisha Trilogy. When Nalia arrives in Morocco to fulfill Malek's third and final wish, she's not expecting it to be easy. Especially because Malek isn't the only one after Solomon's sigil, an ancient magical ring that gives its wearer the power to control the entire jinn race. Nalia has also promised to take Raif, leader of the jinn revolution, to its remote location. Though Nalia is free of the bottle and shackles that once bound her to Malek as his slave, she's in more danger than ever before and no closer to rescuing her imprisoned brother. Meanwhile, Malek's past returns with a vengeance, and his well-manicured facade crumbles as he confronts the darkness within himself; and Raif must decide what's more important: his love for Nalia or his devotion to the cause of Arjinnan freedom.

This e-book will review special features of the cerebral circulation and how they contribute to the physiology of the brain. It describes structural and functional properties of the cerebral circulation that are unique to the brain, an organ with high metabolic demands and the need for tight water and ion homeostasis. Autoregulation is pronounced in the brain, with myogenic, metabolic and neurogenic mechanisms contributing to maintain relatively constant blood flow during both increases and decreases in pressure. In addition, unlike peripheral organs where the majority of vascular resistance resides in small arteries and arterioles, large extracranial and intracranial arteries contribute significantly to vascular resistance in the brain. The prominent role of large arteries in cerebrovascular resistance helps maintain blood flow and protect downstream vessels during changes in perfusion pressure. The cerebral endothelium is also unique in that its barrier properties are in some way more like epithelium than endothelium in the periphery. The cerebral endothelium, known as the blood-brain barrier, has specialized tight junctions that do not allow ions to pass freely and has very low hydraulic conductivity and transcellular transport. This special configuration modifies Starling's forces in the brain microcirculation such that ions retained in the vascular lumen oppose water movement due to hydrostatic pressure. Tight water regulation is necessary in the brain because it has limited capacity for expansion within the skull. Increased intracranial pressure due to vasogenic edema can cause severe neurologic complications and death.

Adequate blood supply to the eye is an important prerequisite for normal visual function. Over the past 40 years our knowledge of ocular blood flow regulation has improved significantly. This reader-friendly textbook provides a comprehensive overview of the current knowledge of ocular blood flow. Lavishly illustrated, it evaluates the wide array of methods that have been used to measure ocular blood flow. Furthermore, it not only offers the reader an evidence-based summary of the physiological and pharmacological properties of ocular blood flow regulation, but also demonstrates the ocular blood flow abnormalities in different vascular diseases. This book will enhance the understanding of all who are interested in learning more about ocular blood flow in health and disease.

This presentation describes various aspects of the regulation of tissue oxygenation, including the roles of the circulatory system, respiratory system, and blood, the carrier of oxygen within these components of the cardiorespiratory system. The respiratory system takes oxygen from the atmosphere and transports it by diffusion from the air in the alveoli to the blood flowing through the pulmonary capillaries. The cardiovascular system then moves the oxygenated blood from the heart to the microcirculation of the various organs by convection, where oxygen is released from hemoglobin in the red blood cells and moves to the parenchymal cells of each tissue by diffusion. Oxygen that has diffused into cells is then utilized in the mitochondria to produce adenosine triphosphate (ATP), the energy currency of all cells. The mitochondria are able to produce ATP until the oxygen tension or PO2 on the cell surface falls to a critical level of about 4–5 mm Hg. Thus, in order to meet the energetic needs of cells, it is important to maintain a continuous supply of oxygen to the mitochondria at or above the critical PO2 . In order to accomplish this desired outcome, the cardiorespiratory system, including the blood, must be capable of regulation to ensure survival of all tissues under a wide range of circumstances. The purpose of this presentation is to provide basic information about the operation and regulation of the cardiovascular and respiratory systems, as well as the properties of the blood and parenchymal cells, so that a fundamental understanding of the regulation of tissue oxygenation is achieved.