This book will be of interest to mathematical statisticians and biometricians interested in block designs. The emphasis of the book is on the randomization approach to block designs. After presenting the general theory of analysis based on the randomization model in Part I, the constructional and combinatorial properties of design are described in Part II. The book includes many new or recently published materials.

The book is composed of two volumes, each consisting of five chapters. In Vol ume I, following some statistical motivation based on a randomization model, a general theory of the analysis of experiments in block designs has been de veloped. In the present Volume II, the primary aim is to present methods of that satisfy the statistical requirements described in constructing block designs Volume I, particularly those considered in Chapters 3 and 4, and also to give some catalogues of plans of the designs. Thus, the constructional aspects are of predominant interest in Volume II, with a general consideration given in Chapter 6. The main design investigations are systematized by separating the material into two contents, depending on whether the designs provide unit efficiency fac tors for some contrasts of treatment parameters (Chapter 7) or not (Chapter 8). This distinction in classifying block designs may be essential from a prac tical point of view. In general, classification of block designs, whether proper or not, is based here on efficiency balance (EB) in the sense of the new termi nology proposed in Section 4. 4 (see, in particular, Definition 4. 4. 2). Most of the attention is given to connected proper designs because of their statistical advantages as described in Volume I, particularly in Chapter 3. When all con trasts are of equal importance, either the class of (v - 1; 0; O)-EB designs, i. e.

The book is composed of two volumes, each consisting of five chapters. In Vol ume I, following some statistical motivation based on a randomization model, a general theory of the analysis of experiments in block designs has been de veloped. In the present Volume II, the primary aim is to present methods of that satisfy the statistical requirements described in constructing block designs Volume I, particularly those considered in Chapters 3 and 4, and also to give some catalogues of plans of the designs. Thus, the constructional aspects are of predominant interest in Volume II, with a general consideration given in Chapter 6. The main design investigations are systematized by separating the material into two contents, depending on whether the designs provide unit efficiency fac tors for some contrasts of treatment parameters (Chapter 7) or not (Chapter 8). This distinction in classifying block designs may be essential from a prac tical point of view. In general, classification of block designs, whether proper or not, is based here on efficiency balance (EB) in the sense of the new termi nology proposed in Section 4. 4 (see, in particular, Definition 4. 4. 2). Most of the attention is given to connected proper designs because of their statistical advantages as described in Volume I, particularly in Chapter 3. When all con trasts are of equal importance, either the class of (v - 1; 0; O)-EB designs, i. e.

This text provides a conceptual systematization and a practical tool for the randomization of between-subjects and within-subjects experimental designs.

Praise for the First Edition “All medical statisticians involved in clinical trials should read this book...” - Controlled Clinical Trials Featuring a unique combination of the applied aspects of randomization in clinical trials with a nonparametric approach to inference, Randomization in Clinical Trials: Theory and Practice, Second Edition is the go-to guide for biostatisticians and pharmaceutical industry statisticians. Randomization in Clinical Trials: Theory and Practice, Second Edition features: Discussions on current philosophies, controversies, and new developments in the increasingly important role of randomization techniques in clinical trials A new chapter on covariate-adaptive randomization, including minimization techniques and inference New developments in restricted randomization and an increased focus on computation of randomization tests as opposed to the asymptotic theory of randomization tests Plenty of problem sets, theoretical exercises, and short computer simulations using SAS® to facilitate classroom teaching, simplify the mathematics, and ease readers’ understanding Randomization in Clinical Trials: Theory and Practice, Second Edition is an excellent reference for researchers as well as applied statisticians and biostatisticians. The Second Edition is also an ideal textbook for upper-undergraduate and graduate-level courses in biostatistics and applied statistics. William F. Rosenberger, PhD, is University Professor and Chairman of the Department of Statistics at George Mason University. He is a Fellow of the American Statistical Association and the Institute of Mathematical Statistics, and author of over 80 refereed journal articles, as well as The Theory of Response-Adaptive Randomization in Clinical Trials, also published by Wiley. John M. Lachin, ScD, is Research Professor in the Department of Epidemiology and Biostatistics as well as in the Department of Statistics at The George Washington University. A Fellow of the American Statistical Association and the Society for Clinical Trials, Dr. Lachin is actively involved in coordinating center activities for clinical trials of diabetes. He is the author of Biostatistical Methods: The Assessment of Relative Risks, Second Edition, also published by Wiley.