A groundbreaking history of how the US Post made the nineteenth-century American West. There were five times as many post offices in the United States in 1899 than there are McDonald's restaurants today. During an era of supposedly limited federal government, the United States operated the most expansive national postal system in the world. In this cutting-edge interpretation of the late nineteenth-century United States, Cameron Blevins argues that the US Post wove together two of the era's defining projects: western expansion and the growth of state power. Between the 1860s and the early 1900s, the western United States underwent a truly dramatic reorganization of people, land, capital, and resources. It had taken Anglo-Americans the better part of two hundred years to occupy the eastern half of the continent, yet they occupied the West within a single generation. As millions of settlers moved into the region, they relied on letters and newspapers, magazines and pamphlets, petitions and money orders to stay connected to the wider world. Paper Trails maps the spread of the US Post using a dataset of more than 100,000 post offices, revealing a new picture of the federal government in the West. The western postal network bore little resemblance to the civil service bureaucracies typically associated with government institutions. Instead, the US Post grafted public mail service onto private businesses, contracting with stagecoach companies to carry the mail and paying local merchants to distribute letters from their stores. These arrangements allowed the US Post to rapidly spin out a vast and ephemeral web of postal infrastructure to thousands of distant places. The postal network's sprawling geography and localized operations forces a reconsideration of the American state, its history, and the ways in which it exercised power.

Jennifer Renee Blevins's debut memoir, Limited by Body Habitus: An American Fat Story, sheds light on her experiences living with the emotional and psychological struggles of taking up space in a fat-phobic world. Bringing together experiences of personal and national trauma, Blevins adeptly weaves the tale of her father's gastric bypass surgery and subsequent prolonged health crisis with the environmental catastrophe of the Deepwater Horizon oil spill. Blevins looks to each of these events as a "leak" of American society's pitfalls and shortcomings. These intertwined narratives, both disasters that could have been avoided, reveal points of failure in our systems of healthcare and environmental conservation. Incorporating pieces from her life, such as medical transcripts and quotes from news programs, Blevins composes a mosaic of our modern anxieties. Even through despair, she finds hope in mending broken relationships and shows us how we can flourish as individuals and as a nation despite our struggles. Fierce and haunting, this memoir creates a space of narrative through body, selfhood, family, and country.

Discover how biomarkers can boost the success rate of drug development efforts As pharmaceutical companies struggle to improve the success rate and cost-effectiveness of the drug development process, biomarkers have emerged as a valuable tool. This book synthesizes and reviews the latest efforts to identify, develop, and integrate biomarkers as a key strategy in translational medicine and the drug development process. Filled with case studies, the book demonstrates how biomarkers can improve drug development timelines, lower costs, facilitate better compound selection, reduce late-stage attrition, and open the door to personalized medicine. Biomarkers in Drug Development is divided into eight parts: Part One offers an overview of biomarkers and their role in drug development. Part Two highlights important technologies to help researchers identify new biomarkers. Part Three examines the characterization and validation process for both drugs and diagnostics, and provides practical advice on appropriate statistical methods to ensure that biomarkers fulfill their intended purpose. Parts Four through Six examine the application of biomarkers in discovery, preclinical safety assessment, clinical trials, and translational medicine. Part Seven focuses on lessons learned and the practical aspects of implementing biomarkers in drug development programs. Part Eight explores future trends and issues, including data integration, personalized medicine, and ethical concerns. Each of the thirty-eight chapters was contributed by one or more leading experts, including scientists from biotechnology and pharmaceutical firms, academia, and the U.S. Food and Drug Administration. Their contributions offer pharmaceutical and clinical researchers the most up-to-date understanding of the strategies used for and applications of biomarkers in drug development.

Winner of the Missouri History Book Award, from the State Historical Society of Missouri Winner of the Arkansiana Award, from the Arkansas Library Association Geologic forces raised the Ozarks. Myth enshrouds these hills. Human beings shaped them and were shaped by them. The Ozarks reflect the epic tableau of the American people—the native Osage and would-be colonial conquerors, the determined settlers and on-the-make speculators, the endless labors of hardscrabble farmers and capitalism of visionary entrepreneurs. The Old Ozarks is the first volume of a monumental three-part history of the region and its inhabitants. Brooks Blevins begins in deep prehistory, charting how these highlands of granite, dolomite, and limestone came to exist. From there he turns to the political and economic motivations behind the eagerness of many peoples to possess the Ozarks. Blevins places these early proto-Ozarkers within the context of larger American history and the economic, social, and political forces that drove it forward. But he also tells the varied and colorful human stories that fill the region's storied past—and contribute to the powerful myths and misunderstandings that even today distort our views of the Ozarks' places and people. A sweeping history in the grand tradition, A History of the Ozarks, Volume 1: The Old Ozarks is essential reading for anyone who cares about the highland heart of America.

1935-42 decisions originally reported currently in the Standard federal tax service, and 1941-42 also in the Federal estate and gift tax service, and 19 - in the Federal excise tax reports.