This book covers the basic principles and advanced methods used in the advancement of bioelectronics for therapeutic purposes. This book provides a thorough examination of the development and progress in bioelectronics devices and biosensors, emphasizing current improvements in individualized diagnostics using biosensing modules, tools, and approaches. It offers useful insights into the creation of biosensors for individualized healthcare diagnostics by analyzing the underlying principles of sensing methods. This book primarily emphasizes the incorporation of biosensing technologies into wearable, implantable, and biomedical devices. These advancements are transforming healthcare by enabling uninterrupted monitoring and immediate data gathering, ultimately improving patient care. The book also highlights the significance of downsizing biosensor platforms, demonstrating approaches that enhance the compactness and efficiency of these devices while maintaining their performance. The book also discusses point-of-care devices, which are of great importance. These devices are essential in clinical laboratories and care units, such as ICUs and ambulatory settings, since they provide fast, precise, and immediate diagnostic capabilities. The book showcases the most recent breakthroughs in personalized diagnostics via the use of biosensing-based bioelectronics devices, highlighting its capacity to revolutionize the provision of healthcare. This book examines the real-world uses of biosensor technology in customized healthcare throughout various chapters. It explores the customization of these devices to cater to the specific requirements of each patient, enabling accurate and prompt medical treatments. This book is a valuable resource for academics, practitioners, and enthusiasts in the subject of bioelectronics and healthcare. It combines in-depth scientific discussions with practical real-world applications. In essence, this book serves as a foundation for comprehending the profound influence of biosensor technology on personalized health care. This book encourages readers to investigate the promising opportunities that await in the field of bioelectronics, where groundbreaking devices and methods are poised to revolutionize medical diagnostics and patient treatment.

Advanced Biosensors for Health Care Applications highlights the different types of prognostic and diagnostic biomarkers associated with cancer, diabetes, Alzheimer's disease, brain and retinal diseases, cardiovascular diseases, bacterial infections, as well as various types of electrochemical biosensor techniques used for early detection of the potential biomarkers of these diseases. Many advanced nanomaterials have attracted intense interests with their unique optical and electrical properties, high stability, and good biocompatibility. Based on these properties, advanced nanoparticles have been used as biomolecular carriers, signal producers, and signal amplifiers in biosensor design. Recent studies reported that there are several diagnostic methods available, but the major issue is the sensitivity and selectivity of these approaches. This book outlines the need of novel strategies for developing new systems to retrieve health information of patients in real time. It explores the potential of nano-multidisciplinary science in the design and development of smart sensing technology using micro-nanoelectrodes, novel sensing materials, integration with MEMS, miniaturized transduction systems, novel sensing strategy, that is, FET, CMOS, System-on-a-Chip (SoC), Diagnostic-on-a-Chip (DoC), and Lab-on-a-Chip (LOC), for diagnostics and personalized health-care monitoring. It is a useful handbook for specialists in biotechnology and biochemical engineering. Describes advanced nanomaterials for biosensor applications Relates the properties of available nanomaterials to specific biomarkers applications Includes diagnosis and electrochemical studies based on biosensors Explores the potential of nano-multidisciplinary science to design and develop smart sensing technologies Describes novel strategies for developing a new class of assay systems to retrieve the desired health information

Biosensors in Precision Medicine: From Fundamentals to Future Trends covers important topics regarding biomarkers, including biomarker discovery, validation, application in precision medicine, the principles of biosensors, their use in precision medicine, important analytical parameters, recent advances in bioreceptors and transduction, and more. Finally, the hottest trends of biosensors in precision medicine, including lab-on-a-chip and wearable devices, advances towards telemedicine, machine learning, artificial intelligence and the commerciality of these devices are discussed. Provides a timely review of the state-of-the-art developments in biosensors and their applications in precision medicine Presents an evaluation of case studies, along with real-life examples Addresses recent trends on biosensors for precision medicine

Smart Biosensors in Medical Care discusses the characteristics of biosensors and their potential applications in healthcare. This book is aimed at professionals, scientists and engineers who are interested in integrating biosensors into medical care systems for patients. It also provides fundamental and foundational knowledge for undergraduate and post graduate students. The book presents a comprehensive view of up-to-date requirements in hardware and communication, offers future perspectives on next-generation medical care systems, and includes global case studies of recent system operations in healthcare. Sections cover smart biosensors, such as wearable, implantable, patch based, and enzyme based for medical care. Advances in ubiquitous sensing applications for healthcare is a series which covers new systems based on ubiquitous sensing for healthcare (USH). Volumes in this series cover a wide range of interdisciplinary areas, including wireless sensors networks, wireless body area networks, Big data, Internet-of-Things (IoT), security, monitoring, real time data collection, data management, systems design/analysis, and much more. Covers the basics of biosensor based medical care data analysis and management Discusses data transmission techniques, presenting applications with extensive studies for biosensor based medical healthcare systems Offers solutions to the challenges of designing biosensor based medical healthcare systems

The critical goal of nanobiosensors is to detect any biochemical and/or biophysical signal related to a specific disease at the level of a single or few molecules. Nanobiosensors have been successful for in vitro as well as in vivo detection of several biomolecules. It is expected that this technology will revolutionize point-of-care and personalized diagnostics, and will be extremely applicable for early disease detection. This book starts with a brief introduction of the biosensors and then focuses mainly on the emerging nanobiosensor technologies which are geared towards onsite clinical applications and those which can be used as a personalized diagnostic device. Written by an international team of researchers who are actively developing these technologies, Nanobiosensors for Personalized and Onsite Biomedical Diagnosis covers the latest advances in the field of biosensors and biosensing applications. This important book includes an assessment of some current and emerging technologies for detecting protein biomarkers and other potential cancer biomarkers and is essential reading for researchers and graduate students in the field. Medics including radiologists and clinicians will also find it invaluable.

Wearable biomarker sensors have made significant strides in the realm of personalized healthcare, permitting the seamless acquisition of physiological data from non-invasively sourced biofluids. This research delves deeper into this frontier, investigating the potential of these sensors to monitor specific molecular biomarkers that provide granular insights into an individual's physiological and psychological states. In this thesis, three principal domains were particularly addressed: native electroactive biomarker detection, electroenzymatic detection of metabolites, and aptamer detection of xenobiotics and hormones.In chapter 2, we addressed the inherent challenges of employing voltammetry for the analysis of native electroactive biomarkers like uric acid. By introducing a fouling-resistant sensing interface that combines a boron-doped diamond electrode with a hydrophilic chitosan membrane, we provided an effective solution to the biofouling challenges that typically plague the analysis of untreated biofluids. In chapter 3 and chapter 4, our research tapped into the capabilities of oxidoreductase enzymes for indirectly reactive biomarker electroenzymatic detection. In chapter 3, we revealed the inherent limitations of the traditionally used mediator-free sensing interface for wearable applications, and devised an alternative that incorporates a permselective membrane and a platinum/carbon-nanotube-based electroanalysis layer. This approach is adaptable to measure a wide range of vital metabolites like glucose, lactate, and choline. Furthermore, in chapter 4, our design of a unique cofactor-integrated biosensing framework, utilizing cofactor immobilized single-wall carbon nanotubes, laid the foundation for broad in vivo enzymatic sensing, specifically capitalizing on nicotinamide adenine dinucleotide-based enzymatic reactions. In chapter 5 and chapter 6, we shifted the focus to the aptamer detection of xenobiotics and hormones. In chapter 5, by integrating an aptamer functionalized field-effect-transistor sensing system, our research demonstrated continuous wearable sweat cortisol monitoring. In chapter 6, our innovative microneedle-based electrochemical aptamer biosensor patch offers real-time insights into the pharmacokinetics of drugs in interstitial fluid circulation. Demonstrated through in vivo tests on specific antibiotics such as tobramycin and vancomycin, our advancements in wearable biosensors stand to revolutionize potential applications in healthcare, furnishing users with accurate, prompt, and insightful data about their health metrics.