This useful book is written from a medical perspective and is aimed at academics as well as medical and biomedical engineering students who want to become involved in the design, development, manufacturing or use of prostheses or medical devices. It covers basic information on the complexities of implant and medical device development. The design process, technology assessment, animal experiments, histocompatibility, tissue compatibility and infections are described. In addition, examples of biomaterial applications are presented, showing the diversity of biomaterials.This is the first book that guides the reader through the complicated process of medical product development. Different technical and medical aspects of medical implants are highlighted by a group of authors who are actively involved in biomaterial research at the University Medical Center of Groningen, one of the leading hospitals in The Netherlands.

Design of biomedical products / G.J. Verkerke & E.B. van der Houwen -- Animal models in biomaterials research / G. Rakhorst ... [et al.] -- Technology assessment / J.M. Hummel -- Hemocompatibility of medical devices / W. van Oeveren -- Tissue and cell interactions with (bio)materials / T.G. van Kooten & R. Kuijer -- Biomaterials-associated surgery and infection / P.G.M. Maathuis ... [et al.] -- Cardiopulmonary bypass and postoperative organ dysfunction / Y.J. Gu -- Mechanical circulatory support systems / G. Rakhorst & M.E. Erasmus -- Biomaterials-related infections in orthopedic implants / D. Neut & R.L. Diercks -- Biomaterials for voice reconstruction / G.J. Verkerke ... [et al.] -- Biomaterials in ophthalmology / V.W. Renardel de Lavalette & S.A. Koopmans -- Biomaterials in plastic surgery / M.F. Meek -- Surgical meshes : morphology-dependent bacterial colonization / A.F. Engelsman

This book presents an introduction to biomaterials with the focus on the current development and future direction of biomaterials and medical devices research and development in Indonesia. It is the first biomaterials book written by selected academic and clinical experts experts on biomaterials and medical devices from various institutions and industries in Indonesia. It serves as a reference source for researchers starting new projects, for companies developing and marketing products and for governments setting new policies. Chapter one covers the fundamentals of biomaterials, types of biomaterials, their structures and properties and the relationship between them. Chapter two discusses unconventional processing of biomaterials including nano-hybrid organic-inorganic biomaterials. Chapter three addresses biocompatibility issues including in vitro cytotoxicity, genotoxicity, in vitro cell models, biocompatibility data and its related failure. Chapter four describes degradable biomaterial for medical implants, which include biodegradable polymers, biodegradable metals, degradation assessment techniques and future directions. Chapter five focuses on animal models for biomaterial research, ethics, care and use, implantation study and monitoring and studies on medical implants in animals in Indonesia. Chapter six covers biomimetic bioceramics, natural-based biocomposites and the latest research on natural-based biomaterials in Indonesia. Chapter seven describes recent advances in natural biomaterial from human and animal tissue, its processing and applications. Chapter eight discusses orthopedic applications of biomaterials focusing on most common problems in Indonesia, and surgical intervention and implants. Chapter nine describes biomaterials in dentistry and their development in Indonesia.

Regeneration of tissues and organs remains one of the great challenges of clinical medicine, and physicians are constantly seeking better methods for tissue repair and replacement. Tissue engineering and regenerative medicine have been investigated for virtually every organ system in the human body, and progress is made possible by advances in materials science, polymer chemistry, and molecular biology. This book reviews the current status of biomaterials for regenerative medicine, and highlights advances in both basic science and clinical practice. The latest methods for regulating the biological and chemical composition of biomaterials are described, together with techniques for modulating mechanical properties of engineered constructs. Contributors delineate methods for guiding the host response to implantable materials, and explain the use of biologically-inspired materials for optimal biological functionality and compatibility. The book culminates in a discussion of the clinical applications of regenerative medicine. By integrating engineering and clinical medicine, Engineering Biomaterials for Regenerative Medicine examines how tissue engineering and regenerative medicine can be translated into successful therapies to bridge the gap between laboratory and clinic. The book will aid materials scientists and engineers in identifying research priorities to fulfill clinical needs, and will also enable physicians to understand novel biomaterials that are emerging in the clinic. This integrated approach also gives engineering students a sense of the excitement and relevance of materials science in the development of novel therapeutic strategies.

"This book is essential when designing, developing and studying biomedical materials.... provides an excellent review—from a patient, disease, and even genetic point of view—of materials engineering for the biomedical field. ... This well presented book strongly insists on how the materials can influence patients’ needs, the ultimate drive for biomedical engineering. ...[presents an] Interesting and innovative review from a patient focus perspective—the book emphasizes the importance of the patients, which is not often covered in other biomedical material’s books." —Fanny Raisin-Dadre, BioInteractions Ltd., Berkshire, England Going far beyond the coverage in most standard books on the subject, Biomaterials Science: An Integrated Clinical and Engineering Approach offers a solid overview of the use of biomaterials in medical devices, drug delivery, and tissue engineering. Combining discussion of materials science and engineering perspectives with clinical aspects, this book emphasizes integration of clinical and engineering approaches. In particular, it explores various applications of biomaterials in fields including tissue engineering, neurosurgery, hemocompatibility, BioMEMS, nanoparticle-based drug delivery, dental implants, and obstetrics/gynecology. The book engages those engineers and physicians who are applying biomaterials at various levels to: Increase the rate of successful deployment of biomaterials in humans Lower the side-effects of such a deployment in humans Accumulate knowledge and experience for improving current methodologies Incorporate information and understanding relevant to future challenges, such as permanent artificial organ transplants Using a variety of contributors from both the clinical and engineering sides of the fields mentioned above, this book stands apart by emphasizing a need for the often lacking approach that integrates these two equally important aspects.

A succinct introduction to the field of biomaterials engineering, packed with practical insights.