Conventional materials technology has yielded clear improvements in regenerative medicine. Ideally, however, a replacement material should mimic the living tissue mechanically, chemically, biologically and functionally. The use of tissue-engineered products based on novel biodegradable polymeric systems will lead to dramatic improvements in health

Bionanocomposites in Tissue Engineering and Regenerative Medicine explores novel uses of these in tissue engineering and regenerative medicine. This book offers an interdisplinary approach, combining chemical, biomedical engineering, materials science and pharmacological aspects of the characterization, synthesis and application of bionanocomposites. Chapters cover a broad selection of bionanocomposites including chitosan, alginate and more, which are utilized in tissue engineering, wound healing, bone repair, drug formulation, cancer therapy, drug delivery, cartilage regeneration and dental implants. Additional sections of Bionanocomposites in Tissue Engineering and Regenerative Medicine discuss, in detail, the safety aspects and circular economy of bionanocomposites - offering an insight into the commercial and industrial aspects of these important materials. Bionanocomposites in Tissue Engineering and Regenerative Medicine will prove a highly useful text for for those in the fields of biomedical engineering, chemistry, pharmaceutics and materials science, both in academia and industrial R&D groups. Each bionanocomposite type is covered individually, providing specific and detailed information for each material Covers a range of tissue engineering and regenerative medicine applications, from dental and bone engineering to cancer therapy Offers an integrated approach, with contributions from authors across a variety of related disciplines, including biomedical engineering, chemistry and materials science

The growing interest in scaffolding design and increasing research programs dedicated to regenerative medicine corroborate the need for Scaffolding in Tissue Engineering. While certain books and journal articles address various aspects in the field, this is the first current, comprehensive text focusing on scaffolding for tissue engineering.

The articles included in this text highlight the important advances in polymer science that impact tissue engineering. The breadth of polymer science is well represented with the relevance of both polymer chemistry and morphology emphasized in terms of cell and tissue response.

Frontiers in Tissue Engineering is a carefully edited compilation of state-of-the-art contributions from an international authorship of experts in the diverse subjects that make up tissue engineering. A broad representation of the medical, scientific, industrial and regulatory community is detailed in the book. The work is an authoritative and comprehensive reference source for scientists and clinicians working in this emerging field. The book is divided into three parts: fundamentals and methods of tissue engineering, tissue engineering applied to specialised tissues, and tissue engineering applied to organs. The text offers many novel approaches, including a detailed coverage of cell-tissue interactions at cellular and molecular levels; cell-tissue surface, biochemical, and mechanical environments; biomaterials; engineering design; tissue-organ function; new approaches to tissue-organ regeneration and replacement of function; ethical considerations of tissue engineering; and government regulation of tissue-engineered products.

Over the past decade, significant advances in the fields of stem cell biology, bioengineering, and animal models have converged on the discipline of regenerative medicine. Significant progress has been made leading from pre-clinical studies through phase 3 clinical trials for some therapies. This volume provides a state-of-the-art report on tissue engineering toward the goals of tissue and organ restoration and regeneration. Examples from different organ systems illustrate progress with growth factors to assist in tissue remodeling; the capacity of stem cells for restoring damaged tissues; novel synthetic biomaterials to facilitate cell therapy; transplantable tissue patches that preserve three-dimensional structure; synthetic organs generated in culture; aspects of the immune response to transplanted cells and materials; and suitable animal models for non-human clinical trials. The chapters of this book are organized into six sections: Stem Cells, Biomaterials and the Extracellular Environment, Engineered Tissue, Synthetic Organs, Immune Response, and Animal Models. Each section is intended to build upon information presented in the previous chapters, and set the stage for subsequent sections. Throughout the chapters, the reader will observe a common theme of basic discovery informing clinical translation, and clinical studies in animals and humans guiding subsequent experiments at the bench.

This book explores in depth a wide range of new biomaterials that hold great promise for applications in regenerative medicine. The opening two sections are devoted to biomaterials designed to direct stem cell fate and regulate signaling pathways. Diverse novel functional biomaterials, including injectable nanocomposite hydrogels, electrosprayed nanoparticles, and waterborne polyurethane-based materials, are then discussed. The fourth section focuses on inorganic biomaterials, such as nanobioceramics, hydroxyapatite, and titanium dioxide. Finally, up-to-date information is provided on a wide range of smart natural biomaterials, ranging from silk fibroin-based scaffolds and collagen type I to chitosan, mussel-inspired biomaterials, and natural polymeric scaffolds. This is one of two books to be based on contributions from leading experts that were delivered at the 2018 Asia University Symposium on Biomedical Engineering in Seoul, Korea – the companion book examines in depth the latest enabling technologies for regenerative medicine.