The series, Hematology reviews, focuses on key developments in Soviet fundamental and applied research, making recent medical advances in the USSR available to the researcher who does not read Russian. Topics reviewed in this volume include the biochemical and physiological mechanisms of blood clotting, the molecular and biological bases of hemostasis and the role played by prostaglandins in the regulation of blood clotting and fibrinolysis. Book club price, $31. Annotation copyrighted by Book News, Inc., Portland, OR

New updated edition first published with Cambridge University Press. This new edition includes 29 chapters on topics as diverse as pathophysiology of atherosclerosis, vascular haemodynamics, haemostasis, thrombophilia and post-amputation pain syndromes.

Hemopoiesis Regulation Mechanisms under Stress by Goldberg and Dygai describes recent results concerning the role of the neuroendocrine system and inter-cellular interactions in the regulation of hemopoiesis under stress. The authors also detail the role of the nervous and opioid systems, glucocorticoids, T-lymphocytes, phagocytic mononuclear cells and stromal mechanocytes in the regulation of the proliferation and differentiation of the various types of hemopoietic cells while the organism is under stress. Other articles discuss the hemostatic potential in various blood circulation departments, thrombohemorrhagic syndrome as a fundamental basis of general pathology, and effects of the gravisurgical correction of the aggregate state of blood on the functions of some organs and systems in case of ischemic heart disease. Among the five papers in this volume, RASB System and Hemopoiesis by O.K. Gavrilov characterizes the main types of RASB (Regulation of the Aggregate State of Blood

This book provides the readers with an up-to-date review of the design, structure and function of a representative selection of fibrous proteins in both health and disease. The importance of the α-helical coiled coil, a conformational motif based on the heptad repeat in the amino acid sequence of all α-fibrous proteins (and parts of some globular proteins) is underlined by three Chapters devoted to its design, structure, function and topology. Specific proteins covered in the text and which depend on the coiled coil for their structure and function, include the intermediate filament proteins, tropomyosin, myosin, paramyosin, fibrin and members of the spectrin superfamily. Also described are fibrous proteins based on the β-pleated sheet and collagen conformations. Recombinant structural proteins, especially of silk and collagen, are discussed in the context of developing new biomaterials with varied applications. Established researchers and postgraduate students in the fields of protein chemistry, biochemistry and structural biophysics will find Fibrous Proteins: Structures and Mechanisms to be an invaluable collection of topical reviews that describe the basic advances made in the field of fibrous proteins over the past decade. This book, written by recognized authorities in the field, provides a clear account of the current status of fibrous protein research and, in addition, establishes the basis for deciding the most appropriate directions for future activity, including the applications of protein engineering and the commercial exploitation of new biomaterials.