A comprehensive introduction to optimization with a focus on practical algorithms for the design of engineering systems. This book offers a comprehensive introduction to optimization with a focus on practical algorithms. The book approaches optimization from an engineering perspective, where the objective is to design a system that optimizes a set of metrics subject to constraints. Readers will learn about computational approaches for a range of challenges, including searching high-dimensional spaces, handling problems where there are multiple competing objectives, and accommodating uncertainty in the metrics. Figures, examples, and exercises convey the intuition behind the mathematical approaches. The text provides concrete implementations in the Julia programming language. Topics covered include derivatives and their generalization to multiple dimensions; local descent and first- and second-order methods that inform local descent; stochastic methods, which introduce randomness into the optimization process; linear constrained optimization, when both the objective function and the constraints are linear; surrogate models, probabilistic surrogate models, and using probabilistic surrogate models to guide optimization; optimization under uncertainty; uncertainty propagation; expression optimization; and multidisciplinary design optimization. Appendixes offer an introduction to the Julia language, test functions for evaluating algorithm performance, and mathematical concepts used in the derivation and analysis of the optimization methods discussed in the text. The book can be used by advanced undergraduates and graduate students in mathematics, statistics, computer science, any engineering field, (including electrical engineering and aerospace engineering), and operations research, and as a reference for professionals.

This book provides a comprehensive and up-to-date review of all aspects of childhood Acute Lymphoblastic Leukemia, from basic biology to supportive care. It offers new insights into the genetic pre-disposition to the condition and discusses how response to early therapy and its basic biology are utilized to develop new prognostic stratification systems and target therapy. Readers will learn about current treatment and outcomes, such as immunotherapy and targeted therapy approaches. Supportive care and management of the condition in resource poor countries are also discussed in detail. This is an indispensable guide for research and laboratory scientists, pediatric hematologists as well as specialist nurses involved in the care of childhood leukemia.

Enabling the Business of Agriculture 2019 presents indicators that measure the laws, regulations and bureaucratic processes that affect farmers in 101 countries. The study covers eight thematic areas: supplying seed, registering fertilizer, securing water, registering machinery, sustaining livestock, protecting plant health, trading food and accessing finance. The report highlights global best performers and countries that made the most significant regulatory improvements in support of farmers.

This volume brings together 17 comprehensive, data-rich analyses to provide an updated perspective on the Mexican Gulf of Mexico, Florida and northern Caribbean. The papers span a broad range of scales and disciplines from plate tectonic evolution to sub-basin scale analysis. Papers are broadly categorised into three themes: 1) geological evolution of the basins of the southern Gulf of Mexico in Mexico, Bahamas and Florida and their hydrocarbon potential; 2) evolution of the region’s Late Cretaceous to Neogene orogens and subsequent denudation history; and 3) geological evolution of the basins and crustal elements of the northern Caribbean. This book and its extensive data sets are essential for all academic and exploration geoscientists working in this area. Two large wall maps are included as fold-outs.