In this comprehensive account of the history and treatment of beriberi, Kenneth Carpenter traces the decades of medical and chemical research that solved the puzzle posed by this mysterious disease. Caused by the lack of a minute quantity of the chemical thiamin, or vitamin B1 in the diet, beriberi is characterized by weakness and loss of feeling in the feet and legs, then swelling from fluid retention, and finally heart failure. Western doctors working in Asia after 1870 saw it as the major disease in native armed forces and prisons. It was at first attributed to miasms (poisonous vapors from damp soil) or to bacterial infections. In Java, chickens fed by chance on white rice lost the use of their legs. On brown rice, where the grain still contained its bran and germ, they remained healthy. Studies in Javanese prisons then showed beriberi also occurring where white (rather than brown) rice was the staple food. Birds were used to assay the potency of fractions extracted from rice bran and, after 20 years, highly active crystals were obtained. In another 10 years their structure was determined and "thiamin" was synthesized. Beriberi is a story of contested knowledge and erratic scientific pathways. It offers a fascinating chronicle of the development of scientific thought, a history that encompasses public health, science, diet, trade, expanding empires, war, and technology. From the preface: This is a medical detective story: beginning with the investigation of a disease that has killed or crippled at least a million people, and then following up clues that ranged much wider. One outcome was the production of a synthetic chemical that we now, nearly all of us, consume in small quantities each day in our food. The detectives had a variety of professions and spoke different languages. Their work ranged from studying the health of laborers in a primitive jungle to the painstaking dissection of individual grains of rice under a microscope. The integrated story of their struggles and successes, culled from old volumes in scattered libraries, forms the subject of this book.

Thiamine Deficiency Disease, Dysautonomia, and High Calorie Malnutrition explores thiamine and how its deficiency affects the functions of the brainstem and autonomic nervous system by way of metabolic changes at the level of the mitochondria. Thiamine deficiency derails mitochondrial oxidative metabolism and gives rise to the classic disease of beriberi that, in its early stages, can be considered the prototype for a set of disorders that we now recognize as dysautonomia. This book represents the life's work of the senior author, Dr. Derrick Lonsdale, and a recent collaboration with his co-author Dr. Chandler Marrs. - Presents clinical experience and animal research that have answered questions about thiamine chemistry - Demonstrates that the consumption of empty calories can result in clinical effects that lead to misdiagnosis - Addresses the biochemical changes induced by vitamin deficiency, particularly that of thiamine

In this comprehensive account of the history and treatment of beriberi, Kenneth Carpenter traces the decades of medical and chemical research that solved the puzzle posed by this mysterious disease. Caused by the lack of a minute quantity of the chemical thiamin, or vitamin B1 in the diet, beriberi is characterized by weakness and loss of feeling in the feet and legs, then swelling from fluid retention, and finally heart failure.

On title page & cover: International Rice Research Institute

The history of the medical and scientific debate about the etiology of the disease as it played out between diet theorists and contagionists from 1880 to 1940. In modern Japan, beriberi (or thiamin deficiency) became a public health problem that cut across all social boundaries, afflicting even the Meiji Emperor. During an age of empire building for the Japanese nation, incidence rates in the military ranged from 30 percent in peacetime to 90 percent during war. Doctors and public health officials called beriberi a "national disease" because it festered within the bodies of the people and threatened the health ofthe empire. Nevertheless, they could not agree over what caused the disease, attributing it to a diet deficiency or a microbe. In Beriberi in Modern Japan, Alexander R. Bay examines the debates over the etiologyof this "national disease" during the late nineteenth and early twentieth centuries. Etiological consensus came after World War I, but the struggle at the national level to direct beriberi prevention continued, peaking during wartime mobilization. War served as the context within which scientific knowledge of beriberi and its prevention was made. The story of beriberi research is not simply about the march toward the inevitable discovery of "the beriberi vitamin," but rather the history of the role of medicine in state-making and empire-building in modern Japan. Alexander Bay is assistant professor of history at Chapman University.

In Vitamania, award-winning journalist Catherine Price takes readers on a lively journey through the past, present and future of the mysterious micronutrients known as human vitamins -- an adventure that includes poison squads and political maneuvering, irradiated sheep grease and smuggled rats. Part history, part science, part personal exploration, Price's witty and engaging book reveals how vitamins have profoundly shaped our attitudes toward eating, and investigates the emerging science of how what we eat might affect our offspring for generations to come.--AMAZON.

To achieve and maintain optimal health, it is essential that the vitamins in foods are present in sufficient quantity and are in a form that the body can assimilate. Vitamins inFoods: Analysis, Bioavailability, and Stability presents the latest information about vitamins and their analysis, bioavailability, and stability in foods.