Using the most well-studied behavioral analyses of animal subjects to promote a better understanding of the effects of disease and the effects of new therapeutic treatments on human cognition, Methods of Behavior Analysis in Neuroscience provides a reference manual for molecular and cellular research scientists in both academia and the pharmaceutic

Drug abuse persists as one of the most costly and contentious problems on the nation's agenda. Pathways of Addiction meets the need for a clear and thoughtful national research agenda that will yield the greatest benefit from today's limited resources. The committee makes its recommendations within the public health framework and incorporates diverse fields of inquiry and a range of policy positions. It examines both the demand and supply aspects of drug abuse. Pathways of Addiction offers a fact-filled, highly readable examination of drug abuse issues in the United States, describing findings and outlining research needs in the areas of behavioral and neurobiological foundations of drug abuse. The book covers the epidemiology and etiology of drug abuse and discusses several of its most troubling health and social consequences, including HIV, violence, and harm to children. Pathways of Addiction looks at the efficacy of different prevention interventions and the many advances that have been made in treatment research in the past 20 years. The book also examines drug treatment in the criminal justice setting and the effectiveness of drug treatment under managed care. The committee advocates systematic study of the laws by which the nation attempts to control drug use and identifies the research questions most germane to public policy. Pathways of Addiction provides a strategic outline for wise investment of the nation's research resources in drug abuse. This comprehensive and accessible volume will have widespread relevanceâ€"to policymakers, researchers, research administrators, foundation decisionmakers, healthcare professionals, faculty and students, and concerned individuals.

The study of drug action has benefitted greatly from the development and use of in vivo model systems. In model systems, manipulations and observations can be more rigorously controlled and screens of novel therapeutic agents can be more safely conducted.No single model system provides all of the possible advantages. At one end, mammalian models al

Behavioural models in psychopharmacology are used for different purposes. The main concern of industrial psychopharmacologists is specifically to develop new and improved drugs for the treatment of mental disorders, while basic scientists use animal models to investigate the underlying nature of such conditions. The important distinction between these different perspectives is made explicit for the first time in this book. By considering such conditions as anxiety, depression, mania and schizophrenia, feeding disorders, dementia, and drug dependence, this book provides a comprehensive and critical review of the adequacy of the behavioural procedures used by psychopharmacologists to model psychiatric disorders. Graduate students and research workers in pscyhopharmacology, from both academic and industrial spheres, as well as clinicians, will find this book of considerable interest.

First multi-year cumulation covers six years: 1965-70.

Volumes 7 and 8 of the Handbook were published in 1977. In Volume 7 methods for studying unconditioned and conditioned behavior were reviewed. Attention was given to both ethological methods and operant conditioning techniques as applied to some selected aspects of behavior. Genetic, developmental, and environmental factors influencing behavior were also discussed. In Volume 8, neurotransmitter systems, and in par ticular brain circuits, were discussed in relation to behavior and to the effects of psychoactive drugs on behavior. The coverage was not exhaus tive because of space limitations. The topics selected for review were, at the time, the focus of considerable experimental effort; they included homeostasis-motivated behaviors: sleep, locomotion, feeding, drinking, and sexual behavior. Brain dopamine systems were therefore discussed in depth, since they were already known to be centrally involved in motivated behaviors. Learning mechanisms and emotion were reviewed in the remaining chapters. In 1984 we initiated an update of behavioral pharmacology to review areas of progress within the same scope as the earlier volumes. This update continues in Volume 19. Among the contributions are several that represent important advances in analyzing behavior and the use of more sophisticated methods to define the effect of drugs on particular aspects of behavior. The chapters by Blundell on feeding and Miczek on aggres sion illustrate the sophistication of modern ethopharmacology.