Current procedures used for hazard identification and classification are based on persistence, bioaccumulation, and toxicity measurements. Assessing the Hazard of Metals and Inorganic Metal Substances in Aquatic and Terrestrial Systems provides the basis for improvements to the current model for hazard assessment. The book reviews the scientific un

This latest version of Information Resources in Toxicology (IRT) continues a tradition established in 1982 with the publication of the first edition in presenting an extensive itemization, review, and commentary on the information infrastructure of the field. This book is a unique wide-ranging, international, annotated bibliography and compendium of major resources in toxicology and allied fields such as environmental and occupational health, chemical safety, and risk assessment. Thoroughly updated, the current edition analyzes technological changes and is rife with online tools and links to Web sites. IRT-IV is highly structured, providing easy access to its information. Among the "hot topics covered are Disaster Preparedness and Management, Nanotechnology, Omics, the Precautionary Principle, Risk Assessment, and Biological, Chemical and Radioactive Terrorism and Warfare are among the designated. - International in scope, with contributions from over 30 countries - Numerous key references and relevant Web links - Concise narratives about toxicologic sub-disciplines - Valuable appendices such as the IUPAC Glossary of Terms in Toxicology - Authored by experts in their respective sub-disciplines within toxicology

Risk Management of Complex Inorganic Materials: A Practical Guide facilitates the risk assessment and management of complex inorganic materials around the world by providing accessible and specific guidance on their assessment. Inorganic complex materials, such as ores and concentrates, metal containing- glasses, ceramic and inorganic pigments, alloys, and UVCBs produced during the manufacturing of metals present specificities not addressed by most guidance documents. This book explains the main characteristics of inorganic complex materials affecting their hazard and risk assessment and management, including their source and main uses, also covering hazard and exposure assessment, risk characterization and risk management. It is an essential reference for regulators involved in risk assessment and risk management, industry experts charged of compliance with chemical management program requirements, consultants preparing chemicals management files for companies and regulators, and academics involved in research on complex inorganic materials. - Focuses on key information required to globally manage the risk of inorganic complex material - Includes user-friendly descriptions of methodologies and tools that facilitate chemicals management of such materials - Provides key messages to assist communication on risk assessment and risk management to audiences like regulators, workers and communities living around industrial sites

In aquatic ecosystems, the oligochaetes are often a major component of the community. Their relevance in sediment quality assessment is largely related to their benthic and detritivorous life habit. In this book, we aim to present the state of the art of Pollution Biology using oligochaete worms in laboratory and field studies. Future research will require the combination of a variety of methodological approaches and the integration of the resulting information, avoiding fragmented and often conflicting visions of the relationships of the species with their environment. Current approaches to ecotoxicology and bioaccumulation using ecological risk assessment provide the opportunity to relate community studies with probability of effects. This book addresses three main themes: Ecological and Field Studies using the composition and structure of oligochaete communities, Toxicology and Laboratory Studies, and Bioaccumulation and Trophic Transfer Studies. Two appendices list values of toxicological parameters (LC50, EC50) and several bioaccumulation variables (bioaccumulation factors, biological half-life, toxicokinetic coefficients, and critical body residues) for different oligochaete species. Additional information is provided on Methodological Issues and on the Taxonomy of several oligochaete families, with information on the most recent taxonomic debates. Each chapter includes a critical view, based on the authors’ experience, of a number of current issues which have been raised in the literature.

The chemistry of nickel in biological systems has been intensely investigated since the discovery of the essential role played by this transition metal in the enzyme urease, ca. 1975. Since then, several nickel-dependent enzymes have been discovered and characterized at the molecular level using structural, spectroscopic, and kinetic methods, and insight into reaction mechanisms has been elaborated using synthetic and computational models. The dual role of nickel as both an essential nutrient and as a toxin has prompted efforts to understand the molecular mechanisms of nickel toxicology and to uncover the means by which cells select nickel from among a pool of different and more readily available metal ions and thus regulate the intracellular chemistry of nickel. This latter effort highlights the importance of proteins involved in the extra- and intra-cellular sensing of nickel, the roles of nickel-selective proteins for import and export, and nickel-responsive transcription factors, all of which are important for regulating nickel homeostasis. In this Special Issue, the contributing authors have covered recent advances in many of these aspects of nickel biochemistry, including toxicology, bacterial pathogenesis, carcinogenesis, computational and synthetic models, nickel trafficking proteins, and enzymology.

Given the essential role that primary producers play in aquatic ecosystems, it is imperative that the potential risk of pesticides to the structure and functioning of aquatic plants is adequately assessed. An integration of regulatory and research information from key specialists in the area of environmental regulation, Aquatic Macrophyte Risk Asse