Automated insulin delivery goes by many names: hybrid or full closed loop; artificial pancreas system (APS); "looping" and more. They are not all the same, though. You have choices, ranging from the type of pump body and CGM you want to use, to the algorithm and controller, to the interoperability and remote monitoring options, and more. Like switching from multiple daily injections to an insulin pump, switching from manual diabetes to automated insulin delivery has a learning curve. It's certainly one you can tackle. After all, you're already tackling type 1 diabetes! You already have the base knowledge and experience you need to succeed with a closed loop system, if it's right for you. But you might be wondering how to get ahead of your learning curve before you start or even choose an APS, or you've started and want to dig even deeper into optimizing how an automated insulin delivery system fits into your lifestyle. This book was written for you! It leverages the collective knowledge of the early adopters of do-it-yourself and commercial systems from the past five years and packages it into easy, understandable guides and lessons learned.In this book, you'll find new analogies to help you understand - and explain - this new method of diabetes management, and tips on how to communicate with your healthcare provider(s) about it. You'll see stories and examples from real families and individuals living with type 1 diabetes and how they benefit from artificial pancreas systems, and why they chose and continue to choose to use them. You'll be empowered to understand the basic components of artificial pancreas systems, how they work, and what questions to ask as you peruse your choices now and in the future. This book also includes a foreword by Aaron Kowalski, President and CEO of JDRF, and co-founder of the JDRF Artificial Pancreas Project. "I will immediately recommend this book not just to people looking to use a DIY closed loop system, but also to anybody looking to improve their grasp on the management of type 1 diabetes, whether patient, caregiver, or healthcare provider." - Aaron Neinstein, MD (Endocrinologist, UCSF)

Accelerated Predictive Stability (APS): Fundamentals and Pharmaceutical Industry Practices provides coverage of both the fundamental principles and pharmaceutical industry applications of the APS approach. Fundamental chapters explain the scientific basis of the APS approach, while case study chapters from many innovative pharmaceutical companies provide a thorough overview of the current status of APS applications in the pharmaceutical industry. In addition, up-to-date experiences in utilizing APS data for regulatory submissions in many regions and countries highlight the potential of APS in support of registration stability testing for certain regulatory submissions. This book provides high level strategies for the successful implementation of APS in a pharmaceutical company. It offers scientists and regulators a comprehensive resource on how the pharmaceutical industry can enhance their understanding of a product's stability and predict drug expiry more accurately and quickly. - Provides a comprehensive, one-stop-shop resource for accelerated predictive stability (APS) - Presents the scientific basis of different APS models - Includes the applications and utilities of APS that are demonstrated through numerous case studies - Covers up-to-date regulatory experience

This book contains information on an increasingly common autoimmune disorder. Also called "sticky blood" and Hughes Syndrome, APS makes one's blood clot too easily, creating high risk of stroke, thrombosis, and premature heart attack. It is also implicated in many other health problems including repeated miscarriages, neurological problems, eary dementia and migraines. It is often associated with lupus, and mimics the symptoms of other diseases, including MS. Symptoms include; migraines and headaches, recurrent miscarriage, memory loss, slurred speech, blood clots, poor circulation, muscle pain and cramps, blurred vision, extreme fatigue, epilepsy, strokes, thrombosis and a form of angina. Because of lack of knowledge of APS in the medical establishment, sufferers are often misdiagnosed with MS or other more life-threatening conditions. This book helps the reader identify the symptoms and provides important information on diagnosis and treatment of APS. It contains many moving stories, explaining how people eventually got a diagnosis, their symptoms, the impact of APS on their lives and whether or not treatment has worked. Written in collaboration with Dr. Graham Hughes, the major researcher of APS in the UK, this book provides a clearly written informative look at an important but little-known disease.

Commercial advanced planning and scheduling (APS) systems have been around for about 25 years and have seen widespread adoption in a variety of companies. The promises made by APS system implementations are high, and at the same time, APS projects are complex, costly, and carry a significant risk of failure. There is a great need for guidance on how to successfully implement APS systems, which is why this book was written. In this book, we aim to discuss all facets of APS implementation, from theoretical background to definition, vendor selection, system design and the implementation process. In addition, this book helps readers understand how the underlying concepts were formed, why a concept will work in practice, and when it will not. The contents of this book are based on many years of academic research and APS implementation experience. It draws together theory and practice in production control and explains how theories can be applied to support planning and scheduling processes in practice. This book will help anyone involved in APS implementations to achieve success: human planners generate better plans than before, using the APS.