This book covers modern statistical inference based on likelihood with applications in medicine, epidemiology and biology. Two introductory chapters discuss the importance of statistical models in applied quantitative research and the central role of the likelihood function. The rest of the book is divided into three parts. The first describes likelihood-based inference from a frequentist viewpoint. Properties of the maximum likelihood estimate, the score function, the likelihood ratio and the Wald statistic are discussed in detail. In the second part, likelihood is combined with prior information to perform Bayesian inference. Topics include Bayesian updating, conjugate and reference priors, Bayesian point and interval estimates, Bayesian asymptotics and empirical Bayes methods. Modern numerical techniques for Bayesian inference are described in a separate chapter. Finally two more advanced topics, model choice and prediction, are discussed both from a frequentist and a Bayesian perspective. A comprehensive appendix covers the necessary prerequisites in probability theory, matrix algebra, mathematical calculus, and numerical analysis.

Praise for the first edition: "One of my biggest complaints when I teach introductory statistics classes is that it takes me most of the semester to get to the good stuff—inferential statistics. The author manages to do this very quickly....if one were looking for a book that efficiently covers basic statistical methodology and also introduces statistical software [this text] fits the bill." -The American Statistician Applied Statistical Inference with MINITAB, Second Edition distinguishes itself from other introductory statistics textbooks by focusing on the applications of statistics without compromising mathematical rigor. It presents the material in a seamless step-by-step approach so that readers are first introduced to a topic, given the details of the underlying mathematical foundations along with a detailed description of how to interpret the findings, and are shown how to use the statistical software program Minitab to perform the same analysis. Gives readers a solid foundation in how to apply many different statistical methods. MINITAB is fully integrated throughout the text. Includes fully worked out examples so students can easily follow the calculations. Presents many new topics such as one- and two-sample variances, one- and two-sample Poisson rates, and more nonparametric statistics. Features mostly new exercises as well as the addition of Best Practices sections that describe some common pitfalls and provide some practical advice on statistical inference. This book is written to be user-friendly for students and practitioners who are not experts in statistics, but who want to gain a solid understanding of basic statistical inference. This book is oriented towards the practical use of statistics. The examples, discussions, and exercises are based on data and scenarios that are common to students in their everyday lives.

Praise for the first edition: "One of my biggest complaints when I teach introductory statistics classes is that it takes me most of the semester to get to the good stuff—inferential statistics. The author manages to do this very quickly....if one were looking for a book that efficiently covers basic statistical methodology and also introduces statistical software [this text] fits the bill." -The American Statistician Applied Statistical Inference with MINITAB, Second Edition distinguishes itself from other introductory statistics textbooks by focusing on the applications of statistics without compromising mathematical rigor. It presents the material in a seamless step-by-step approach so that readers are first introduced to a topic, given the details of the underlying mathematical foundations along with a detailed description of how to interpret the findings, and are shown how to use the statistical software program Minitab to perform the same analysis. Gives readers a solid foundation in how to apply many different statistical methods. MINITAB is fully integrated throughout the text. Includes fully worked out examples so students can easily follow the calculations. Presents many new topics such as one- and two-sample variances, one- and two-sample Poisson rates, and more nonparametric statistics. Features mostly new exercises as well as the addition of Best Practices sections that describe some common pitfalls and provide some practical advice on statistical inference. This book is written to be user-friendly for students and practitioners who are not experts in statistics, but who want to gain a solid understanding of basic statistical inference. This book is oriented towards the practical use of statistics. The examples, discussions, and exercises are based on data and scenarios that are common to students in their everyday lives.

This book brings together selected peer-reviewed contributions from various research fields in statistics, and highlights the diverse approaches and analyses related to real-life phenomena. Major topics covered in this volume include, but are not limited to, bayesian inference, likelihood approach, pseudo-likelihoods, regression, time series, and data analysis as well as applications in the life and social sciences. The software packages used in the papers are made available by the authors. This book is a result of the 47th Scientific Meeting of the Italian Statistical Society, held at the University of Cagliari, Italy, in 2014.

The Likelihood plays a key role in both introducing general notions of statistical theory, and in developing specific methods. This book introduces likelihood-based statistical theory and related methods from a classical viewpoint, and demonstrates how the main body of currently used statistical techniques can be generated from a few key concepts, in particular the likelihood. Focusing on those methods, which have both a solid theoretical background and practical relevance, the author gives formal justification of the methods used and provides numerical examples with real data.

This classic textbook builds theoretical statistics from the first principles of probability theory. Starting from the basics of probability, the authors develop the theory of statistical inference using techniques, definitions, and concepts that are statistical and natural extensions, and consequences, of previous concepts. It covers all topics from a standard inference course including: distributions, random variables, data reduction, point estimation, hypothesis testing, and interval estimation. Features The classic graduate-level textbook on statistical inference Develops elements of statistical theory from first principles of probability Written in a lucid style accessible to anyone with some background in calculus Covers all key topics of a standard course in inference Hundreds of examples throughout to aid understanding Each chapter includes an extensive set of graduated exercises Statistical Inference, Second Edition is primarily aimed at graduate students of statistics, but can be used by advanced undergraduate students majoring in statistics who have a solid mathematics background. It also stresses the more practical uses of statistical theory, being more concerned with understanding basic statistical concepts and deriving reasonable statistical procedures, while less focused on formal optimality considerations. This is a reprint of the second edition originally published by Cengage Learning, Inc. in 2001.

Statistics is a subject with a vast field of application, involving problems which vary widely in their character and complexity.However, in tackling these, we use a relatively small core of central ideas and methods. This book attempts to concentrateattention on these ideas: they are placed in a general settingand illustrated by relatively simple examples, avoidingwherever possible the extraneous difficulties of complicatedmathematical manipulation.In order to compress the central body of ideas into a smallvolume, it is necessary to assume a fair degree of mathematicalsophistication on the part of the reader, and the book is intendedfor students of mathematics who are already accustomed tothinking in rather general terms about spaces and functions