Applied Biopharmaceutics and Pharmacokinetics

Applied Biopharmaceutics and Pharmacokinetics
Title Applied Biopharmaceutics and Pharmacokinetics PDF eBook
Author Leon Shargel
Publisher McGraw-Hill/Appleton & Lange
Pages 625
Release 1993
Genre Biopharmaceutics
ISBN 9780838502396

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Modeling in Biopharmaceutics, Pharmacokinetics and Pharmacodynamics

Modeling in Biopharmaceutics, Pharmacokinetics and Pharmacodynamics
Title Modeling in Biopharmaceutics, Pharmacokinetics and Pharmacodynamics PDF eBook
Author Panos Macheras
Publisher Springer Science & Business Media
Pages 446
Release 2006-04-26
Genre Mathematics
ISBN 0387319107

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This book presents a novel modeling approach to biopharamceutics, pharmacokinetics and pharmacodynamic phenomena. It shows how advanced physical and mathematical methods can expand classical models in order to cover heterogeneous drug-biological processes and therapeutic effects in the body. Throughout, many examples are used to illustrate the intrinsic complexity of drug administration related phenomena in the human, justifying the use of advanced modeling methods.

Pharmacokinetic and Pharmacodynamic Data Analysis: Concepts and Applications, Third Edition

Pharmacokinetic and Pharmacodynamic Data Analysis: Concepts and Applications, Third Edition
Title Pharmacokinetic and Pharmacodynamic Data Analysis: Concepts and Applications, Third Edition PDF eBook
Author Johan Gabrielsson
Publisher CRC Press
Pages 926
Release 2001-11-30
Genre Medical
ISBN 9789186274924

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This is a revised and very expanded version of the previous second edition of the book. "Pharmacokinetic and Pharmacodynamic Data Analysis" provides an introduction into pharmacokinetic and pharmacodynamic concepts using simple illustrations and reasoning. It describes ways in which pharmacodynamic and pharmacodynamic theory may be used to give insight into modeling questions and how these questions can in turn lead to new knowledge. This book differentiates itself from other texts in this area in that it bridges the gap between relevant theory and the actual application of the theory to real life situations. The book is divided into two parts; the first introduces fundamental principles of PK and PD concepts, and principles of mathematical modeling, while the second provides case studies obtained from drug industry and academia. Topics included in the first part include a discussion of the statistical principles of model fitting, including how to assess the adequacy of the fit of a model, as well as strategies for selection of time points to be included in the design of a study. The first part also introduces basic pharmacokinetic and pharmacodynamic concepts, including an excellent discussion of effect compartment (link) models as well as indirect response models. The second part of the text includes over 70 modeling case studies. These include a discussion of the selection of the model, derivation of initial parameter estimates and interpretation of the corresponding output. Finally, the authors discuss a number of pharmacodynamic modeling situations including receptor binding models, synergy, and tolerance models (feedback and precursor models). This book will be of interest to researchers, to graduate students and advanced undergraduate students in the PK/PD area who wish to learn how to analyze biological data and build models and to become familiar with new areas of application. In addition, the text will be of interest to toxicologists interested in learning about determinants of exposure and performing toxicokinetic modeling. The inclusion of the numerous exercises and models makes it an excellent primary or adjutant text for traditional PK courses taught in pharmacy and medical schools. A diskette is included with the text that includes all of the exercises and solutions using WinNonlin.

Pharmacotherapy Casebook

Pharmacotherapy Casebook
Title Pharmacotherapy Casebook PDF eBook
Author Terry L. Schwinghammer
Publisher McGraw-Hill Medical Publishing
Pages 484
Release 2005
Genre Medical
ISBN

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This casebook is designed to help students develop the skills required to identify and resolve drug therapy problems through the use of patient case studies.

Basic Pharmacokinetics and Pharmacodynamics

Basic Pharmacokinetics and Pharmacodynamics
Title Basic Pharmacokinetics and Pharmacodynamics PDF eBook
Author Sara E. Rosenbaum
Publisher John Wiley & Sons
Pages 440
Release 2012-09-10
Genre Medical
ISBN 111819778X

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With its clear, straightforward presentation, this text enables you to grasp all the fundamental concepts of pharmacokinetics and pharmacodynamics. This will allow you to understand the time course of drug response and dosing regimen design. Clinical models for concentration and response are described and built from the basic concepts presented in earlier chapters. Your understanding of the material will be enhanced by guided computer exercises conducted on a companion website. Simulations will allow you to visualize drug behavior, experiment with different dosing regimens, and observe the influence of patient characteristics and model parameters. This makes the book ideal for self-study. By including clinical models of agonism, indirect drug effects, tolerance, signal transduction, and disease progression, author Sara Rosenbaum has created a work that stands out among introductory-level textbooks in this area.You'll find several features throughout the text to help you better understand and apply key concepts: Three fictitious drugs are used throughout the text to progressively illustrate the development and application of pharmacokinetic and pharmacodynamic principles Exercises at the end of each chapter reinforce the concepts and provide the opportunity to perform and solve common dosing problems Detailed instructions let you create custom Excel worksheets to perform simple pharmacokinetic analyses Because this is an introductory textbook, the material is presented as simply as possible. As a result, you'll find it easy to gain an accurate, working knowledge of all the core principles, apply them to optimize dosing regimens, and evaluate the clinical pharmacokinetic and pharmacodynamic literature.

Rowland and Tozer's Clinical Pharmacokinetics and Pharmacodynamics: Concepts and Applications

Rowland and Tozer's Clinical Pharmacokinetics and Pharmacodynamics: Concepts and Applications
Title Rowland and Tozer's Clinical Pharmacokinetics and Pharmacodynamics: Concepts and Applications PDF eBook
Author Hartmut Derendorf
Publisher Lippincott Williams & Wilkins
Pages 1334
Release 2019-07-11
Genre Medical
ISBN 1496385896

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Updated with the latest clinical advances, Rowland and Tozer’s Clinical Pharmacokinetics and Pharmacodynamics, Fifth Edition , explains the relationship between drug administration and drug response, taking a conceptual approach that emphasizes clinical application rather than science and mathematics. Bringing a real-life perspective to the topic, the book simplifies concepts and gives readers the knowledge they need to better evaluate drug applications.

Biopharmaceutics and Clinical Pharmacokinetics

Biopharmaceutics and Clinical Pharmacokinetics
Title Biopharmaceutics and Clinical Pharmacokinetics PDF eBook
Author Notari
Publisher CRC Press
Pages 448
Release 1986-08-26
Genre Science
ISBN 9780824775230

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Cover -- Half Title -- Title Page -- Copyright Page -- Dedication -- Table of Contents -- Preface to the Fourth Edition -- Preface to the Third Edition -- Preface to the Second Edition -- Preface to the First Edition -- Nomenclature -- 1: Introduction -- References -- 2: Rates, Rate Constants, and Order -- I. Order -- II. Rates and Rate Constants -- 3: Active and Passive Transport -- I. Introduction -- II. Passive Transport -- III. Active Transport -- References -- 4: Pharmacokinetics -- I. Introduction -- II. Drug Disposition -- III. Constant-Rate Intravenous Infusion -- IV. Compartmental Models and Their Limitations -- V. Absorption Rate Constants -- References -- 5: Biopharmaccutics -- I. Extravascular Administration -- II. Absorption of Drugs from the Gastrointestinal Tract -- III. Factors Influencing Bioavailability -- IV. Evaluation of the Bioavailability of a Single Drug -- V. Drug Delivery to Prolong Duration -- References -- 6: Dosage Regimens -- I. Introduction -- II. Accumulation During Repetitive Dosing -- III. Adjustment of Dosage Regimen in Renal Failure -- IV. Multiple Dosing of Constant-Rate Intravenous Infusions -- References -- 7: Pharmacokinetic Aspects of Structural Modifications in Drug Design and Therapy -- I. Introduction -- II. Antimicrobial Agents -- III. Pharmacokinetics of Prodrugs -- IV. Stereoisomers -- References -- 8: Pharmacokinetic Applications in Clinical Practice -- I. Introduction -- II. Pharmacokinetic Drug Interactions -- III. Clinical Pharmacokinetics -- References -- Appendix -- Index