A characteristic of traditional medicinal practices, such as traditional Chinese medicines (TCMs) and Indian ayurveda, is the abundant use of plants as drugs. However, the bottleneck in the use of herbal drugs is the control of their safety, effectiveness, and quality. Good quality control (QC) is necessary to achieve the standards of modern medicines. Liquid chromatography, being a powerful universal separation technique, is widely available in laboratories and easily hyphenated with other spectroscopic and biochemical techniques. A number of LC-based strategies—such as multicomponent quantitation, fingerprinting, bioaffinity chromatography, and on-flow assays for screening—have been used for the comprehensive QC of TCMs, lead finding, and identification of active constituents. In this chapter, the applications and development of such LC-based methods for TCMs and other herbal drugs are presented and discussed. Some future trends are given.

This book provides a comprehensive and up-to-date account of the HPLC technology and fingerprints of commonly-used Chinese herbs. It contains HPLC fingerprints of over 40 traditional Chinese medicinal herbs and details of their sources, production and quality control. The book provides a practical review of the techniques, relevant materials, and the particular demands for using HPLC in traditional Chinese medicinal herb applications. It also covers HPLC methods used to analyze the herbs.High-performance liquid chromatography (HPLC) is increasingly used in the field of traditional Chinese medicine for obtaining fingerprints of Chinese medicinal herbs. Advantages such as high speed, high resolution, high sensitivity, stability, accuracy, and automation make it one of the leading techniques used for quality control, standardization of planting, and new drug development in traditional Chinese medicine.To date, no other books on HPLC fingerprints of traditional Chinese medicinal herbs have been published in English. This is the first book in English devoted to providing readers with state-of-the-art information on HPLC applied in the analysis of traditional Chinese medicinal herbs.

Chinmedomics: The Integration of Serum Pharmacochemistry and Metabolomics to Elucidate the Scientific Value of Traditional Chinese Medicine uses new experimental techniques and research to open doors in drug discovery and development related to traditional Chinese medicine (TCM). This book features a unique approach that combines chemometric analysis with metabolomics studies to illuminate significant changes that have occurred in syndrome states while simultaneously analyzing the efficacy of chemical ingredients in herbal medicines. Chapters provide cutting-edge information on traditional medicine, analytical technology, natural products, metabolomics, bioinformatics and their applications. This book provides a valuable resource for pharmacologists, pharmaceutical scientists, medicinal plant researchers, pharmacognosists and chemists working with TCM and highlights ways to further research and advances in this area in the future. - Presents a practical guide for new practitioners of Chinmedomics with insights on the current use and future development of this method - Each chapter includes an introduction, method, references to the latest literature, possible mechanisms of action and applications - Edited by the leading experts of research related to Chinmedomics

Serum Pharmacochemistry of Traditional Chinese Medicine: Technologies, Strategies and Applications provides a valuable and indispensable guide on the latest methods, research advances, and applications in this area. Chapters offer cutting-edge information on pharmacokinetics and pharmacodynamics, analytical chemistry, traditional medicine, natural products, bioinformatics, new technologies, therapeutic applications, and more. For researchers and students in academia and industry, this book provides a hands-on description of experimental techniques, along with beneficial guidelines to help advance research in the fields of Traditional Chinese Medicine and drug development. - Provides a valuable guide for practitioners of serum pharmacochemistry of Traditional Chinese Medicine, along with insights to its current use and future applications - Edited and written by leading scientists at the forefront of this research - Presents well written chapters that include an introduction, description of the method, and identification of chemical constituents, with applications and references to the latest research and literature

Chromatography is a technique that is used for the separation of a mixture. The solutes or components of a mixture are separated based on the relative proportion of individual solutes distributed between a moving fluid stream and a contiguous stationary phase. Chromatography can be analytical or preparative. Depending on the mode of operation, geometry of the system, phases involved and the retention mechanism, chromatography can be of two types- column chromatography and planar chromatography. These techniques are of immense use in various chemical and biological fields. This book outlines the processes and applications of chromatography in detail. It includes some of the vital pieces of work being conducted across the world, on various topics related to chromatography. It will prove to be immensely beneficial to students and researchers in this field.