Vol. 4 covers the late Roman period to the rise of Islam. Focuses especially on the growth and development of rabbinic Judaism and of the major classical rabbinic sources such as the Mishnah, Jerusalem Talmud, Babylonian Talmud and various Midrashic collections.

Thirty-five years ago, Kamen wrote a study of the Inquisition that received high praise. This present work, based on over 30 years of new research, is not simply a complete revision of the earlier book. Innovative in its presentation, point of view, information, and themes, it will revolutionize further study in the field.