First English translation of the classical work on the principles of physiological investigation in life sciences.

This work has been selected by scholars as being culturally important and is part of the knowledge base of civilization as we know it. This work is in the public domain in the United States of America, and possibly other nations. Within the United States, you may freely copy and distribute this work, as no entity (individual or corporate) has a copyright on the body of the work. Scholars believe, and we concur, that this work is important enough to be preserved, reproduced, and made generally available to the public. To ensure a quality reading experience, this work has been proofread and republished using a format that seamlessly blends the original graphical elements with text in an easy-to-read typeface. We appreciate your support of the preservation process, and thank you for being an important part of keeping this knowledge alive and relevant.

This monograph has been written for clinicians who are involved in the management of the dizzy patient and for scientists with a particular interest in the multi-sensorimotor mechan isms that subserve spatial orientation, motion perception, and ocular motor and postural con trol. Special emphasis has been put on making the correct diagnosis, and detailed recommendations have been given for specific treatments. The second edition has resulted in an almost completely new book due to the dramatic expansion in the 1990s of our understanding of vestibular function and dis orders. A few rele vant examples include the novel concept of canalolithiasis, as opposed to cupulolithiasis, both of which are established causes of typical posterior and horizontal canal benign paroxysmal positioning vertigo; familial episodic ataxia land II have been identified as inherited chan nelopathies; otolithic syndromes were recognized as a variety separate from semicircular canal syndromes; several new central vestibular syndromes have been described, localized, and attributed to vestibular pathways and centres; a new classification based on the three major planes of action of the vestibulo-ocular reflex is available for central vestibular syn dromes; and the mystery of the location and function of the multisensory vestibular cortex is slowly being unravelled. This book differs from other clinical textbooks in that it is not divided into two parts: anatomy and physiology, on the one hand, and disorders, on the other.

Cholinergic-Monoaminergic Interactions in the Brain investigates dynamic synaptic mechanisms in the brain and their links to various behaviors and related functional processes. More specifically, it explores neurochemical interactions by focusing on the relationship between cholinergic and monoaminergic mechanisms in the central nervous system. It also presents morphologic data to highlight the importance of structure in understanding function, particularly, that of the neostriatum and the role of acetylcholine and neurochemicals. Organized into six sections comprised of 18 chapters, this volume begins with an overview of various models of cholinergic-monoaminergic and other chemical interactions, based in part on interactive processes that are believed to operate in the peripheral nervous system. The next chapters focus on experimental observations on electrophysiologic and neurochemical interactions in the brain and the functional correlates of such interactions. The discussion then turns to the neurohistochemical and neurobiochemical aspects of cholinergic-monoaminergic interactions, the effects on neostriatal acetylcholine levels, and the synthesis of the cortico-neostriatal and thalamo-neostriatal pathways. The reader is also introduced to the effects of lesion in the globus pallidus, the electrophysiology of interactions, the effects of drugs thought to preferentially affect monoaminergic or related neurotransmission mechanisms on acetylcholine in the brain, and whether dopamine is excitatory or inhibitory upon neostriatal neurons. Finally, the book assesses the significance of central cholinergic-monoaminergic interactions for functional processes, both normal and pathologic. This book is a valuable resource for neuroscientists, pharmacologists, histochemists, behavioral biologists, psychobiologists, and psychologists.

An original account of willful ignorance and how this principle relates to modern probability and statistical methods Through a series of colorful stories about great thinkers and the problems they chose to solve, the author traces the historical evolution of probability and explains how statistical methods have helped to propel scientific research. However, the past success of statistics has depended on vast, deliberate simplifications amounting to willful ignorance, and this very success now threatens future advances in medicine, the social sciences, and other fields. Limitations of existing methods result in frequent reversals of scientific findings and recommendations, to the consternation of both scientists and the lay public. Willful Ignorance: The Mismeasure of Uncertainty exposes the fallacy of regarding probability as the full measure of our uncertainty. The book explains how statistical methodology, though enormously productive and influential over the past century, is approaching a crisis. The deep and troubling divide between qualitative and quantitative modes of research, and between research and practice, are reflections of this underlying problem. The author outlines a path toward the re-engineering of data analysis to help close these gaps and accelerate scientific discovery. Willful Ignorance: The Mismeasure of Uncertainty presents essential information and novel ideas that should be of interest to anyone concerned about the future of scientific research. The book is especially pertinent for professionals in statistics and related fields, including practicing and research clinicians, biomedical and social science researchers, business leaders, and policy-makers.

"If a student researcher had only one handbook on their bookshelf, Miller and Salkind′s Handbook would certainly have to be it. With the updated material, the addition of the section on ethical issues (which is so well done that I′m recommending it to the departmental representative to the university IRB), and a new Part 4 on "Qualitative Methods", the new Handbook is an indispensable resource for researchers." --Dan Cover, Department of Sociology, Furman University " I have observed that most instructors want to teach methodology "their way" to imbue the course with their own approach; Miller-Salkind allows one to do this easily. The book is both conceptually strong (e.g., very good coverage of epistemology, research design and statistics) and at the same time provides a wealth of practical knowledge (scales, indices, professional organizations, computer applications, etc.) In addition, it covers the waterfront of methodology." --Michael L. Vasu, Director of Information Technology, North Carolina State University "A unique and excellent reference tool for all social science researchers, and a good textbook for graduate students and senior year undergraduate classes. These students are about to enter the real life of research, and need a handy and comprehensive tool as a starting point that offers shortcuts for getting into real research projects. For a small project, the book offers enough information to get the project started. For big projects, the book is ideal for information on where to look for things and examples." --Jianhong Liu, Department of Sociology, Rhode Island College The book considered a "necessity" by many social science researchers and their students has been revised and updated while retaining the features that made it so useful. The emphasis in this new edition is on the tools graduate students and more advanced researchers need to conduct high quality research. Features/Benefits: Provides step-by-step instruction for students′ research training by beginning with how to find a creative idea, a middle-range theory, and initial hypothesis and proceeds through design, proposal, collection and analysis of data followed by writing, reporting and publication Section on scales and indices are organized so that readers can quickly locate and find the type of scale or index in which they may be interested All sections are now followed by useful and well-considered reference sections so that readers can read more about each topic Includes updated coverage on new scales, internal and external validity, and new analytic techniques with extensive references on each Presents extensive coverage of how to prepare manuscripts for publication, including a list of all journals covered by Sociological Abstracts along with the editorial office address and URL for each entry Discusses the importance of policy research with presentation and discussion of specific models as an adjunct to both applied and basic research techniques Provides extensive coverage of funding opportunities including those offered by the National Institutes of Health, the National Science Foundation, and a directory of private funding sources including relevant contact information New to this edition: New Part 4 by John Creswell and Ray Maietta provides a comprehensive introduction to qualitative methods including a review of existing computer applications for collecting and analyzing data New and more current reviews and commentaries have replaced dated or no longer relevant excerpts Thousands of new references on the assessment of important sociological variables as well as references to such topics as statistical analysis, computer applications, and specific topics Thoroughly updated information on the use of computers and online research techniques, including beginning and intermediate material about the Internet and its use by the modern research scientist Coherent and thoughtful review of the most popular statistical analysis software packages New guidelines and discussion of ethical practices in social and behavioral science research, including extensive coverage of institutional review board procedures and activities Expansion of social indicators to include international coverage Plus, there is an extensive and well-organized table of contents with four levels of headings; and, for the first time in the history of the book, a comprehensive index.