Progress in the applications of biotechnology depends on a wide base of basic as well as applied sciences. The output of biotechnology has already proved itself in many different fields, from health to biomining, and from agriculture to enzyme "breeding". The objectives of the Biotechnology Annual Review series is to provide readers with the needed in-depth knowledge by reviewing specific topics in each volume. In this way, it is easier for scientists to keep in touch with progress and applications in biotechnology. Up-to-date topics are reviewed that are related to regulatory affairs, social impact, biodiversity and patent issues, as well as production and technology.

Praise for the First Edition "This pioneering work, in which Rao provides a comprehensive and up-to-date treatment of small area estimation, will become a classic...I believe that it has the potential to turn small area estimation...into a larger area of importance to both researchers and practitioners." —Journal of the American Statistical Association Written by two experts in the field, Small Area Estimation, Second Edition provides a comprehensive and up-to-date account of the methods and theory of small area estimation (SAE), particularly indirect estimation based on explicit small area linking models. The model-based approach to small area estimation offers several advantages including increased precision, the derivation of "optimal" estimates and associated measures of variability under an assumed model, and the validation of models from the sample data. Emphasizing real data throughout, the Second Edition maintains a self-contained account of crucial theoretical and methodological developments in the field of SAE. The new edition provides extensive accounts of new and updated research, which often involves complex theory to handle model misspecifications and other complexities. Including information on survey design issues and traditional methods employing indirect estimates based on implicit linking models, Small Area Estimation, Second Edition also features: Additional sections describing the use of R code data sets for readers to use when replicating applications Numerous examples of SAE applications throughout each chapter, including recent applications in U.S. Federal programs New topical coverage on extended design issues, synthetic estimation, further refinements and solutions to the Fay-Herriot area level model, basic unit level models, and spatial and time series models A discussion of the advantages and limitations of various SAE methods for model selection from data as well as comparisons of estimates derived from models to reliable values obtained from external sources, such as previous census or administrative data Small Area Estimation, Second Edition is an excellent reference for practicing statisticians and survey methodologists as well as practitioners interested in learning SAE methods. The Second Edition is also an ideal textbook for graduate-level courses in SAE and reliable small area statistics.

Bayesian Statistics is a dynamic and fast-growing area of statistical research with wide-ranging and far-reaching applications across science, technology, commerce, and industry. This Handbook explores contemporary Bayesian analysis across a variety of techniques and application areas.