Mysterio is the master of illusions and he has convinced the world that Spider-Man is a Super Villain! Can Spider-Man prove that he's a hero and take down this clever trickster?

Collects Amazing Spider-Man (1963) #13, #66-67 And #141-142; Web Of Spider-Man (1985) #90; Friendly Neighborhood Spider-Man (2005) #11-13; Amazing Spider-Man (1999) #618-620; And Material From Peter Parker, The Spectacular Spider-Man (1976) #50-51. When Spider-Man battles Mysterio, the stakes are far more deadly than just smoke and mirrors! Find out exactly how dangerous the master of illusion can be in this collection of Spidey’s greatest showdowns with one of his oldest foes! Relive Quentin Beck’s sinister, Steve Ditko-drawn debut — and larger-than-life battles illustrated by John Romita Sr., Ross Andru, Marcos Martin and more! Mysterio’s mists and mysteries plague Peter Parker in wicked ways, from shrinking him to six inches tall to seemingly summoning all of Spidey’s greatest foes! But is it always Beck under the iconic fishbowl helmet — or are there multiple Mysterios? And can even death stop his deceptions?!

Two new characters emerge to stalk Peter Parker and threaten to destroy everything he holds dear.

Mysterio, Master of Illusions, has placed Peter's(Spidey's) Aunt May in terrible danger, and the only way he can save her is by facing off against his most deadly foes, including Doc Ock, the Green Goblin, and Venom!

Search each scene to find the items and the information Spider-Man needs to complete his mission.