Alternatives for Dermal Toxicity Testing
Title | Alternatives for Dermal Toxicity Testing PDF eBook |
Author | Chantra Eskes |
Publisher | Springer |
Pages | 585 |
Release | 2017-11-21 |
Genre | Medical |
ISBN | 3319503537 |
This book provides comprehensive information on the alternative (non-animal) dermal toxicity test methods currently available for industrial, regulatory, and academic use and also explores potential future developments. It encompasses all areas of dermal toxicity, including skin irritation, skin corrosion, skin sensitization, UV-induced effects, and skin genotoxicity. An individual chapter is devoted to each test method, with coverage of the scientific basis, validation status and regulatory acceptance, applications and limitations, available protocols, and potential role within testing strategies. In addition, perspectives from the test developer are presented, for example regarding critical steps in the protocol. The closing section addresses areas that may be of relevance for the future of dermal toxicity safety testing, including the validation and regulatory acceptance of integrated testing strategies, novel complex skin models, and high-throughput screening techniques.
Alternative Toxicological Methods
Title | Alternative Toxicological Methods PDF eBook |
Author | Harry Salem |
Publisher | CRC Press |
Pages | 616 |
Release | 2003-03-26 |
Genre | Medical |
ISBN | 0203008790 |
Bringing together the recent and relevant contributions of over 125 scientists from industry, government, and academia in North America and Western Europe, Alternative Toxicological Methods explores the development and validation of replacement, reduction, and refinement alternatives (the 3Rs) to animal testing. Internationally recognized scientist
Advances In Animal Alternatives For Safety And Efficacy Testing
Title | Advances In Animal Alternatives For Safety And Efficacy Testing PDF eBook |
Author | Harry Salem |
Publisher | CRC Press |
Pages | 474 |
Release | 1997-11-12 |
Genre | Medical |
ISBN | 9781439805817 |
Presents up-to-date concepts and approaches to the theory and practice of alternatives to animal testing and promotes technology transfer. The text addresses some of the ramifications of the National Institutes of Health Revitalization Act of 1993 which instructs the NIH to fund replacement, reduction and refinement alternatives. It also describes
Alternatives to Animal Testing
Title | Alternatives to Animal Testing PDF eBook |
Author | Hajime Kojima |
Publisher | Springer |
Pages | 130 |
Release | 2018-12-27 |
Genre | Medical |
ISBN | 9811324476 |
This open access book presents recent advances in the pure sciences that are of significance in the quest for alternatives to the use of animals in research and describes a variety of practical applications of the three key guiding principles for the more ethical use of animals in experiments – replacement, reduction, and refinement, collectively known as the 3Rs. Important examples from across the world of implementation of the 3Rs in the testing of cosmetics, chemicals, pesticides, and biologics, including vaccines, are described, with additional information on relevant regulations. The coverage also encompasses emerging approaches to alternative tests and the 3Rs. The book is based on the most informative contributions delivered at the Asian Congress 2016 on Alternatives and Animal Use in the Life Sciences. It will be of value for those working in R&D, for graduate students, and for educators in various fields, including the pharmaceutical and cosmetic sciences, pharmacology, toxicology, and animal welfare. The free, open access distribution of Alternatives to Animal Testing is enabled by the Creative Commons Attribution license in International version 4: CC BY 4.0.
Alternative Methods for Toxicity Testing
Title | Alternative Methods for Toxicity Testing PDF eBook |
Author | |
Publisher | |
Pages | 192 |
Release | 1986 |
Genre | Animal experimentation |
ISBN |
Alternatives to Animal Testing
Title | Alternatives to Animal Testing PDF eBook |
Author | Michael Balls |
Publisher | Royal Society of Chemistry |
Pages | 137 |
Release | 2006 |
Genre | Medical |
ISBN | 0854042113 |
Animal experimentation has long been a controversial issue with impassioned arguments on both sides of the debate. Increasingly it has become more expedient and feasible to develop new methods that avoid the use of animals. There is agreement on both sides that reduction and refinement of experiments on animals should be an important goal for the industries involved. Alternatives to Animal Testing, written by leading experts in the field, discusses the issues involved and approaches that can be taken. Topics include; the safety evaluation of chemicals, international validation and barriers to the validation of alternative tests, in vitro testing for endocrine disruptors, intelligent approaches to safety evaluation of chemicals, alternative tests and the regulatory framework. The book provides an up-to-date discussion of the current state of development of alternatives to animal testing and is ideal for professionals and academics in the field. It would also be of use for graduate students wishing to pursue a career in the pharmaceutical and cosmetic industries.
Principles and Practice of Skin Toxicology
Title | Principles and Practice of Skin Toxicology PDF eBook |
Author | Robert Chilcott |
Publisher | John Wiley & Sons |
Pages | 392 |
Release | 2008-07-31 |
Genre | Science |
ISBN | 0470773081 |
Written by authorities in the field, this book provides a “bottom up” approach to studying skin toxicology. Principles and Practice of Skin Toxicology clearly outlines basic concepts, cites historical and modern references and contains a dictionary for easy reference. The inclusion of global legislation and regulatory aspects on the topic makes this a comprehensive review for every practitioner, clinical researcher in industry and academia, and MSc and PhD student of toxicology. Different sections cover skin structure and function, principles and measurement of skin absorption, clinical aspects of dermal toxicity and in vitro alternatives. A section on regulatory and legislative aspects includes case studies from the UK that fulfill European Union and US FDA requirements. A glossary provides definitions of technical terms, and the chapters contain an introduction, learning boxes and summary section for ease of use. Includes a chapter on drug delivery through the skin. Addresses risk assessment: a key area for the interpretation of skin absorption data that is rarely covered.