On 4 October 1992, El Al Israel Airlines Flight 1862, a Boeing 747-200 Freighter, departed from Schiphol Airport, Amsterdam, on its way to Tel Aviv, Israel. Seven minutes after take-off the plane lost engine no. 3 and 4 and crashed in an apartment block just outside Amsterdam, killing 43 people. The investigation concluded that the design and certification of the B 747 pylon was inadequate to provide the required level of safety. Furthermore the system to ensure structural integrity by inspection failed.

On February 24, 1989, United Airlines flight 811, a Boeing 747-122, lost a cargo door as it was climbing between 22,000 and 23,000 feet after taking off from Honolulu, Hawaii, en route to Sydney, Australia with 355 persons aboard. As a result of the incident nine of the passengers were ejected from the airplane and lost at sea. The cargo door was recovered in two pieces from the ocean floor at a depth of 14,200 feet on September 26 and October 1, 1990. The probable cause of this accident was a faulty switch or wiring in the door control system. Contributing to the cause of the accident was a deficiency in the design of the cargo door locking mechanisms. Also contributing to the accident was a lack of timely corrective actions by Boeing and the FAA following a 1987 cargo door opening incident on a Pan Am B-747.

On December 29, 1972 an Eastern Air Lines' Lockheed L-1011, as Flight 401 on its way from John F. Kennedy International Airport, New York, to Miami International Airport, Miami, Florida, crashed at 2342 eastern standard time in the Everglades, approximately 18 miles west northwest of Miami International Airport. The aircraft was destroyed. There were 163 passengers and a crew of 13 aboard the aircraft, 99 people died in the crash. The flight was diverted because of problems with the nose landing gear The aircraft climbed to 2,000 feet while the crew attempted to correct the problem. Surviving passengers and crewmembers stated that the flight was routine and operated normally before impact with the ground. The National Transportation Safety Board determines that the probable cause of this accident, was preoccupation with a malfunction of the nose landing gear position indicating system distracted the crew's attention from the instruments and allowed the descent to go unnoticed.

On 25 February 2009 a Boeing 737-800, flight TK1951, operated by Turkish Airlines was flying from Istanbul in Turkey to Amsterdam Schiphol Airport. There were 135 people on board. During the approach to the runway at Schiphol airport, the aircraft crashed about 1.5 kilometres from the threshold of the runway. This accident cost the lives of four crew members, and five passengers, 120 people sustained injuries. The crash was caused by a malfunctioning radio altimeter and a failure to implement the stall recovery procedure correctly.

On May 25, 1979, American Airlines Flight 191, a McDonnell-Douglas DC-10-10 aircraft, on its way from Chicago to Los Angeles, crashed just after take-off near Chicago-O'Hare International Airport, Illinois. During the take off the left engine and pylon assembly and about 3 ft of the leading edge of the left wing separated from the aircraft and fell to the runway. Flight 191 crashed killing two hundred and seventy one persons on board and two persons on the ground. The accident remains the deadliest airliner accident to occur on United States soil.

On December 20, 1995, American Airlines Flight 965, a Boeing 757-223, was on a scheduled passenger flight from Miami, Florida, U.S.A., to Cali, Colombia. Close to its final destination the pilots erroneously cleared the approach waypoints from their navigation computer. When the controller asked the pilots to check back in over Tulua, north of Cali, it was no longer programmed into the computer. They were lost and the aircraft crashed into a mountain. Of the 163 people on board, 4 passengers survived miraculously the accident.