A look at the methods and algorithms used to predict protein structure A thorough knowledge of the function and structure of proteins is critical for the advancement of biology and the life sciences as well as the development of better drugs, higher-yield crops, and even synthetic bio-fuels. To that end, this reference sheds light on the methods used for protein structure prediction and reveals the key applications of modeled structures. This indispensable book covers the applications of modeled protein structures and unravels the relationship between pure sequence information and three-dimensional structure, which continues to be one of the greatest challenges in molecular biology. With this resource, readers will find an all-encompassing examination of the problems, methods, tools, servers, databases, and applications of protein structure prediction and they will acquire unique insight into the future applications of the modeled protein structures. The book begins with a thorough introduction to the protein structure prediction problem and is divided into four themes: a background on structure prediction, the prediction of structural elements, tertiary structure prediction, and functional insights. Within those four sections, the following topics are covered: Databases and resources that are commonly used for protein structure prediction The structure prediction flagship assessment (CASP) and the protein structure initiative (PSI) Definitions of recurring substructures and the computational approaches used for solving sequence problems Difficulties with contact map prediction and how sophisticated machine learning methods can solve those problems Structure prediction methods that rely on homology modeling, threading, and fragment assembly Hybrid methods that achieve high-resolution protein structures Parts of the protein structure that may be conserved and used to interact with other biomolecules How the loop prediction problem can be used for refinement of the modeled structures The computational model that detects the differences between protein structure and its modeled mutant Whether working in the field of bioinformatics or molecular biology research or taking courses in protein modeling, readers will find the content in this book invaluable.

This book constitutes the refereed proceedings of the 16th Conference of the Canadian Society for Computational Studies of Intelligence, AI 2003, held in Halifax, Canada in June 2003. The 30 revised full papers and 24 revised short papers presented were carefully reviewed and selected from 106 submissions. The papers are organized in topical sections on knowledge representation, search, constraint satisfaction, machine learning and data mining, AI and Web applications, reasoning under uncertainty, agents and multi-agent systems, AI and bioinformatics, and AI and e-commerce.

This book contains the extended versions of 33 papers selected among those originally presented at the Sixth Congress of the Italian Association for Artificial Intelligence (AI*IA). The congress of the AI*IA is the most relevant Italian event in the field of Artificial Intelligence, and has been receiving much attention from many researchers and practitioners of different countries. The sixth congress was held in Bologna, 14-17 September 1999, and was organized in twelve scientific sessions and one demo session. The papers here collected report on significant work carried out in different areas of artificial intelligence, in Italy and other countries. Areas such as automated reasoning, knowledge representation, planning, and machine learning continue to be thoroughly investigated. The collection also shows a growing interest in the field of multi-agent systems, perception and robotics, and temporal reasoning. Many people contributed in different ways to the success of the congress and to this volume. First of all, the members of the program committee who efficiently handled the reviewing of the 64 papers submitted to the congress, and later on the reviewing of the 41 papers submitted for publication in this volume. They provided three reviews for each manuscript, by relying on the support of valuable additional reviewers. The members of the organizing committee, namely Rosangela Barruffi, Paolo Bellavista, Anna Ciampolini, Marco Cremonini, Enrico Denti, Marco Gavanelli, Mauro Gaspari, Michela Milano, Rebecca Montanari, Andrea Omicini, Fabrizio Riguzzi, Cesare Stefanelli, and Paolo Torroni, worked hardy supporting at solving problems during and after the congress.

This book constitutes the refereed proceedings of the scientific track of the 7th Congress of the Italian Association for Artificial Intelligence, AI*IA 2001, held in Bari, Italy, in September 2001. The 25 revised long papers and 16 revised short papers were carefully reviewed and selected for inclusion in the volume. The papers are organized in topical sections on machine learning; automated reasoning; knowledge representation; multi-agent systems; natural language processing; perception, vision, and robotics; and planning and scheduling.

Current Trends and Advances in Computer-Aided Intelligent Environmental Data Engineering merges computer engineering and environmental engineering. The book presents the latest finding on how data science and AI-based tools are being applied in environmental engineering research. This application involves multiple domains such as data science and artificial intelligence to transform the data collected by intelligent sensors into relevant and reliable information to support decision-making. These tools include fuzzy logic, knowledge-based systems, particle swarm optimization, genetic algorithms, Monte Carlo simulation, artificial neural networks, support vector machine, boosted regression tree, simulated annealing, ant colony algorithm, decision tree, immune algorithm, and imperialist competitive algorithm. This book is a fundamental information source because it is the first book to present the foundational reference material in this new research field. Furthermore, it gives a critical overview of the latest cross-domain research findings and technological developments on the recent advances in computer-aided intelligent environmental data engineering. Captures the application of data science and artificial intelligence for a broader spectrum of environmental engineering problems Presents methods and procedures as well as case studies where state-of-the-art technologies are applied in actual environmental scenarios Offers a compilation of essential and critical reviews on the application of data science and artificial intelligence to the entire spectrum of environmental engineering

"This book investigages granular computing (GrC), which emerged as one of the fastest growing information processing paradigms in computational intelligence and human-centric systems"--Provided by publisher.

This book constitutes the refereed proceedings of the 7th Pacific-Asia Conference on Knowledge Discovery and Data Mining, PAKDD 2003, held in Seoul, Korea in April/Mai 2003. The 38 revised full papers and 20 revised short papers presented together with two invited industrial contributions were carefully reviewed and selected from 215 submissions. The papers are presented in topical sections on stream mining, graph mining, clustering, text mining, Bayesian networks, association rules, semi-structured data mining, classification, data analysis, and feature selection.