Adverse reactions to medicines continue to present a burden on healthcare, causing considerable morbidity and mortality. Aswell as knowing about the benefits of medicines, healthcare professionals need to understand the problem of adverse drugreactions and be aware of how they can be prevented and managed. This essential and practical guide has been extensively revised and updated to include three new chapters on adverse effectsof drugs in pregnancy, pharmacogenetics, and side effects and patients. Case studies are provided with each chapter.

This book provides the current state of knowledge of basic mechanisms of adverse drug reactions (ADRs). The main focus is on idiosyncratic drug reactions because they are the most difficult to deal with. It starts with a general description of the major targets for ADRs followed by a description of what are presently believed to be mediators and biochemical pathways involved in idiosyncratic drug reactions. There is also a description of several examples of ADRs that serve to illustrate specific aspects of ADR mechanisms. Eventually the book shows that ultimately better methods are needed to predict which drug candidates are likely to cause ADRs and which patients are at increased risk. But at present research seems to be far from this goal.

v. 1. Research findings -- v. 2. Concepts and methodology -- v. 3. Implementation issues -- v. 4. Programs, tools and products.

Reviews the biochemical and physiological abnormalities in each of the body's organ systems, enabling investigators to decide if the problem is of drug-induced origin. Much of the material is presented as a series of observations with accompanying questions which should be addressed in order to make an accurate diagnosis. Includes useful flow charts for the management of adverse drug events and examples of specific report forms.

Building on the success of the 14 previous editions, this remarkable reference has been extensively reorganized and expanded and now comprises almost 1,500 individual drug articles providing the most complete coverage of adverse reactions and interactions found anywhere. Each article contains detailed and authoritative information about the adverse effects of each drug, with comprehensive references to the primary literature making this a must have for any academic or medical library, pharmacologist, regulatory organization, hospital dispensary or pharmaceutical company. Now available online for all academic, corporate or government institution as well as individuals viaScience Direct! The online version provides an unparalleled depth of coverage and functionality by offering convenient desktop access and enhanced features such as increased searchability, extensive internal cross-linking and fully downloadable and printable full-text, HTML or PDF articles. Enhanced encyclopedic format with drug monographs now organised alphabetically Completely expanded coverage of each drug - thalidomide warranted three sentences in Meyler's 14th edition, but is now a 13 page extensive monograph Clearer, systematic organization of information for easier reading including case histories to provide perspective on each listing Extensive bibliography with over 40,000 references - Meyler's 15th edition incorporates all relevant citations from Meyler's 14th, but also includes relevant citations from previous editions of Meyler's and Side Effects of Drugs Annuals to give a historical perspective on the use and safety of drugs

A key text for all those involved in pharmacovigilance. Detection of new adverse drug reactions is fundamental to the protection of patients from harm that may occur as a result of medication. This book explores the methods used to investigate new adverse drug reactions, discussing all elements from the scientific background and animal toxicology through to worldwide regulatory and ethical issues. Stephens' Detection of New Adverse Drug Reactions provides comprehensive and up-to-date coverage of material fundamentally important to all those active in the field, whether they work in the pharmaceutical industry, drug regulatory authorities or in academia. The fifth edition of this classic reference work includes new chapters on: * vaccine safety surveillance * managing drug safety issues with marketed products * operational aspects of drug safety function * safety of biotechnology products * future of pharmacovigilance Reviews of previous editions: "This book surpasses all its educational aims. Not only is the subject matter covered comprehensively but the material is presented in a very user-friendly manner. The editors have succeeded in producing a highly-specific, definitive reference book which doubles as a most enjoyable read." Commended by the 1999 BMA Medical Book Competition "For anyone entering the field of adverse reaction monitoring one could not wish for a better primer" International Journal of Risk and Safety in Medicine