This book summarizes the NATO Advanced Research Workshop (ARW) on “Nanoengineered Systems for Regenerative Medicine” that was organized under the auspices of the NATO Security through Science Program. I would like to thank NATO for supporting this workshop via a grant to the co-directors. The objective of ARW was to explore the various facets of regenerative me- cine and to highlight role of the “the nano-length scale” and “nano-scale systems” in defining and controlling cell and tissue environments. The development of novel tissue regenerative strategies require the integration of new insights emerging from studies of cell-matrix interactions, cellular signalling processes, developmental and systems biology, into biomaterials design, via a systems approach. The chapters in the book, written by the leading experts in their respective disciplines, cover a wide spectrum of topics ranging from stem cell biology, developmental biology, ce- matrix interactions, and matrix biology to surface science, materials processing and drug delivery. We hope the contents of the book will provoke the readership into developing regenerative medicine paradigms that combine these facets into cli- cally translatable solutions. This NATO meeting would not have been successful without the timely help of Dr. Ulrike Shastri, Sanjeet Rangarajan and Ms. Sabine Benner, who assisted in the organization and implementation of various elements of this meeting. Thanks are also due Dr. Fausto Pedrazzini and Ms. Alison Trapp at NATO HQ (Brussels, Belgium). The commitment and persistence of Ms.

Virtually any disease that results from malfunctioning, damaged, or failing tissues may be potentially cured through regenerative medicine therapies, by either regenerating the damaged tissues in vivo, or by growing the tissues and organs in vitro and implanting them into the patient. Principles of Regenerative Medicine discusses the latest advances in technology and medicine for replacing tissues and organs damaged by disease and of developing therapies for previously untreatable conditions, such as diabetes, heart disease, liver disease, and renal failure. - Key for all researchers and instituions in Stem Cell Biology, Bioengineering, and Developmental Biology - The first of its kind to offer an advanced understanding of the latest technologies in regenerative medicine - New discoveries from leading researchers on restoration of diseased tissues and organs

This book summarizes the NATO Advanced Research Workshop (ARW) on “Nanoengineered Systems for Regenerative Medicine” that was organized under the auspices of the NATO Security through Science Program. I would like to thank NATO for supporting this workshop via a grant to the co-directors. The objective of ARW was to explore the various facets of regenerative me- cine and to highlight role of the “the nano-length scale” and “nano-scale systems” in defining and controlling cell and tissue environments. The development of novel tissue regenerative strategies require the integration of new insights emerging from studies of cell-matrix interactions, cellular signalling processes, developmental and systems biology, into biomaterials design, via a systems approach. The chapters in the book, written by the leading experts in their respective disciplines, cover a wide spectrum of topics ranging from stem cell biology, developmental biology, ce- matrix interactions, and matrix biology to surface science, materials processing and drug delivery. We hope the contents of the book will provoke the readership into developing regenerative medicine paradigms that combine these facets into cli- cally translatable solutions. This NATO meeting would not have been successful without the timely help of Dr. Ulrike Shastri, Sanjeet Rangarajan and Ms. Sabine Benner, who assisted in the organization and implementation of various elements of this meeting. Thanks are also due Dr. Fausto Pedrazzini and Ms. Alison Trapp at NATO HQ (Brussels, Belgium). The commitment and persistence of Ms.

Through the integration of strategies from life science, engineering, and clinical medicine, tissue engineering and regenerative medicine hold the promise of new solutions to current health challenges. This rapidly developing field requires continual updates to the state-of-the-art knowledge in all of the aforementioned sciences. Tissue Engineering

Nanotechnologies in Preventative and Regenerative Medicine demonstrates how control at the nanoscale can help achieve earlier diagnoses and create more effective treatments. Chapters take a logical approach, arranging materials by their area of application. Biomaterials are, by convention, divided according to the area of their application, with each chapter outlining current challenges before discussing how nanotechnology and nanomaterials can help solve these challenges This applications-orientated book is a valuable resource for researchers in biomedical science who want to gain a greater understanding on how nanotechnology can help create more effective vaccines and treatments, and to nanomaterials researchers seeking to gain a greater understanding of how these materials are applied in medicine. - Demonstrates how nanotechnology can help achieve more successful diagnoses at an earlier stage - Explains how nanomaterials can be manipulated to create more effective drug treatments - Offers suggestions on how the use of nanotechnology might have future applications to create even more effective treatments

Biomaterials work in contact with living matter and this gives a number of specific requirements for their surface properties, such as bioinertness or bioactivity, antibiofouling, and so on. Surface engineering based on physical, chemical, physical-chemical, biochemical or biological principles is important for the preparation of biomaterials with the desired biocontact properties. This book helps the reader gain the knowledge to enable them to work in such a rapidly developing area, with a comprehensive list of references given for each chapter. Strategies for tailoring the biological response through the creation of biomaterial surfaces resistant to fouling are discussed. Methods of eliciting specific biomolecular interactions that can be further combined with patterning techniques to engineer adhesive areas in a noninteractive background are also covered. The theoretical basis of surface engineering for improvement of biocontact properties of polymeric biomaterials as well as the current state-of-the-art of the surface engineering of polymeric biomaterials are presented. The book also includes information on the most used conventional and advanced surface engineering methods. The book is targeted at researchers, post-doctorates, graduate students, and those already working in the field of biomaterials with a special interest in the creation of polymeric materials with improved biocontact properties via surface engineering.

Nanotechnology plays a key leading role in developing tools able to identify, measure, and study cellular events at the nanometric level as well as in contributing to the disclosure of unknown biological interactions and mechanisms, which opens the door for advances including nanodevices for diagnostic and therapy, drug delivery systems, and regenerative medicine. In Nanotechnology in Regenerative Medicine: Methods and Protocols, expert researchers in the field provide an overview of a very wide range of currently used technologies and methods that involve nanotechnology principles applicable to tissue regeneration. Being that the application of nanotechnology to regenerative medicine is a very broad field, this book focuses its interests on particular areas such as its use as a means to produce efficient platforms and structures for tissue engineering, delivery systems and biosensors, as well as the use of some techniques to study materials surfaces and the interactions between cells, biomolecules, and surfaces at the nanoscale. Written in the highly successful Methods in Molecular BiologyTM series format, chapters include introductions to their related topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and accessible, Nanotechnology in Regenerative Medicine: Methods and Protocols provides established scientists, junior researchers, and students involved in the bioengineering, biotechnology, and biomedical fields with a sound foundation in a variety of vital nanotechnology approaches in regenerative medicine.