The 16 articles in this issue draw on the expertise of internationally recognized experts who have collectively provided cross-cutting reviews with a broad perspective on the current state of the field. The authors have provided succinct, up-to-date clinical perspectives and highlight current controversies and future challenges. As a result, this issue is a cutting-edge compendium of this complex and fast-moving field. Throughout the issue, the reader is encouraged to acquire a more comprehensive perspective by drawing connections between earlier and later articles that are thematically grouped around issues dealing with pathogenesis, diagnosis, and therapy. This issue underscores the vital importance of continued support to encourage and nurture collaboration among clinicians and scientists.

The 16 articles in this issue draw on the expertise of internationally recognized experts who have collectively provided cross-cutting reviews with a broad perspective on the current state of the field. The authors have provided succinct, up-to-date clinical perspectives and highlight current controversies and future challenges. As a result, this issue is a cutting-edge compendium of this complex and fast-moving field. Throughout the issue, the reader is encouraged to acquire a more comprehensive perspective by drawing connections between earlier and later articles that are thematically grouped around issues dealing with pathogenesis, diagnosis, and therapy. This issue underscores the vital importance of continued support to encourage and nurture collaboration among clinicians and scientists.

In this issue of Clinics in Perinatology, guest editors Drs. Nathalie Maitre and Andrea F. Duncan bring their considerable expertise to the topic of Neurological and Developmental Outcomes of High-Risk Neonates. Preterm birth complications are the leading cause of death among children under five years of age, and three-quarters of these deaths could be prevented with current, cost-effective interventions. In this issue, top experts provide neonatologists and perinatologists with the clinical information they need to improve outcomes in high-risk newborns. Contains 15 practice-oriented topics including neonatal opioid withdrawal syndrome; healthcare disparities in high-risk neonates; autism spectrum and high-risk infant phenotypes; NICU transition to home interventions; telehealth and other innovations in NICU follow up; and more. Provides in-depth clinical reviews on neurological and developmental outcomes of high-risk neonates, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.

Guest Editor Adre du Plessis addresses Neonatal Neurology in this issue of Clinics in Perinatology, a companion to his September 2009 issue on Fetal Neurology. Mechanisms and management of acute brain injury is reviewed, including articles on Systemic and cerebral transitional hemodynamics in premature infants, Hypoxic-ischemic brain injury in the term infant, Neuroprotection in the newborn infant, Intracranial hemorrhage in the premature and term newborn, Infection-inflammatory mechanisms of brain injury in the newborn, Neonatal stroke, and Neonatal seizures. Next, Neurodiagnostic advances for the newborn infant is explored, with articles covering, Advanced brain MRI techniques, Advances in Near Infrared Spectroscopy, and Bedside electrocortical monitoring. The issue closes with a section devoted to Longterm neurologic outcome: Mechanisms of dysfunction and recovery, with articles on Longterm outcome in premature infants, Mechanisms of Cerebral Plasticity, The longterm effects of neonatal seizures, Constraint-induced therapy: Plasticity in practice, and Neonatal brain injury and autistic spectrum disorders in survivors.

This issue of Clinics in Perinatology, guest edited by Drs. Alan Spitzer and Dan Ellsbury, examines Quality Improvement in Neonatal and Perinatal Medicine. The first part of the issue addresses Tools of Quality Improvement and includes articles on The Quality Chasm in Neonatal and Perinatal Medicine; Evaluating the Medical Evidence; The Vermont Oxford Network Database; The Pediatrix Clinical Data Warehouse; Role of Regional Collaboratives: The California Perinatal Quality Care Collaborative Model; A Primer on Quality Improvement Methodology; Using Statistical Process Control Methodology; Human Factors in Quality Improvement, Random Safety Audits, Root Cause Analysis, and Failure Mode and Effects Analysis; Collaboration Between Obstetricians and Neonatologists: Perinatal Safety Programs and Improved Clinical Outcomes; and Pay for Performance: A Business Strategy for Quality Improvement in Neonatal-Perinatal Medicine. The second part of this issue addresses Specific Applications of Documented Quality Improvement Methodology in Neonatal and Perinatal Medicine and includes articles on Delivery Room Intervention-Improving the Outcome, Reducing Retinopathy of Prematurity, Improving Breast Milk Use During and After the NICU Stay, Decreasing Catheter Related Bloodstream Infection, and Decreasing Bronchopulmonary Dysplasia.

In this issue of Clinics in Perinatology, guest editors Drs. Nathalie Maitre and Andrea F. Duncan bring their considerable expertise to the topic of Neurological and Developmental Outcomes of High-Risk Neonates. Preterm birth complications are the leading cause of death among children under five years of age, and three-quarters of these deaths could be prevented with current, cost-effective interventions. In this issue, top experts provide neonatologists and perinatologists with the clinical information they need to improve outcomes in high-risk newborns. Contains 15 practice-oriented topics including neonatal opioid withdrawal syndrome; healthcare disparities in high-risk neonates; autism spectrum and high-risk infant phenotypes; NICU transition to home interventions; telehealth and other innovations in NICU follow up; and more. Provides in-depth clinical reviews on neurological and developmental outcomes of high-risk neonates, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.