Advances in Nanomedicine for the Delivery of Therapeutic Nucleic Acids addresses several issues related to safe and effective delivery of nucleic acids (NAs) using nanoparticles. A further emphasis would be laid on the mechanism of delivery of NAs, the barriers encountered and the strategies adapted to combat them. An exhaustive account of the advantages as well shortcomings of all the delivery vectors being employed in delivery of various NAs will be provided. On final note the regulatory aspects of nanoparticles mediated NA would be discussed, with focus on their clinical relevance. The design and development of nucleic acid-based therapeutics for the treatment of diseases arising from genetic abnormalities has made significant progress over the past few years. NAs have been widely explored for the treatment of cancer and infectious diseases or to block cell proliferation and thereby caused diseases. Advances in synthetic oligonucleotide chemistry resulted in synthesis of NAs that are relatively stable in in vivo environments. However, cellular targeting and intracellular delivery of NAs still remains a challenge. Further development of NA-based therapeutics depends on the progress of safe and effective carriers for systemic administration. Nanomedicine has facilitated availability of vectors with diminished cytotoxicity and enhanced efficacy which are rapidly emerging as systems of choice. These vectors protect NAs from enzymatic degradation by forming condensed complexes along with targeted tissue and cellular delivery. During the past few years, a myriad reports have appeared reporting delivery of NAs mediated by nanoparticles. This book will provide an overview of nanoparticles being employed in the in vitro and in vivo delivery of therapeutically relevant NAs like DNA, siRNA, LNA, PNA, etc. Provides a complete overview of the applicatiosn of nanomedicine in the delivery of nucleic acids, from characterization of nanoparticles, to in vitro and in vivo studies Discusses delivery issues of less well explored nucleic acids, like PNAs, Ribozymes, DNAzymes, etc. Summarizes the current state of research in nucleic acid delivery and underscores the future of nanomedicine in this field

Advances in Nano-fertilizers and Nano-pesticides in Agriculture: A Smart Delivery System for Crop Improvement explores the use of nanotechnology for the controlled delivery of pesticides, herbicides and fertilizers that improve the safety of products while also increasing the efficiency of food production and decreased environmental pollution. The development of nanodevices such as smart delivery systems to target specific sites, as well as nanocarriers for chemical controlled release are currently important aspects in novel agriculture and require a strong foundation of understanding, not only the technology, but also the resulting impacts. Fills key knowledge- gaps of bio-nanotechnology, how they interact with plant cells and their biological consequences Focuses on agro-nanotechnology which can be utilized for developing healthy seeds Explores the possibilities of macronutrient nano-based fertilizers

This book focuses on recent advances in the synthesis of nanoparticles, their characterization, and their applications in different fields such as catalysis, photonics, magnetism, and nanomedicine. Nanoparticles receive a large share of the worldwide research activity in contemporary materials science. This is witnessed by the number of scientific papers with "nanoparticle" as a keyword, increasing linearly in the last 10 years from about 16,000 in 2009 to about 50,000 in 2019. This impressive widespread interest stems from the basic science of nanoparticles, which constitute a bridge between the molecular and the bulk worlds, as well as from their technological applications. The preparation of nanoparticles is a crossroad of materials science where chemists, physicists, engineers, and even biologists frequently meet, leading to a continuous improvement of existing techniques and to the invention of new methods. The reader interested in nanoparticles synthesis and properties will here find a valuable selection of scientific cases that cannot cover all methods and applications relevant to the field, but still provide an updated overview on the fervent research activity focused on nanoparticles.

Nanotechnology promises new medical therapies, more rapid and sensitive diagnostic and investigative tools for normal and diseased tissues, and new materials for tissue engineering. This e-book highlights the major current uses, new technologies and future perspectives of nanotechnology in relation to medical applications. Sections in this e-book include nanobiological approaches to imaging, diagnosis and treatment of disease using targeted monoclonal antibodies and siRNA, the medical use of nanomaterials, to nanoelectronic biosensors, and possible future applications of molecular nanotechnolo.

Nanoparticles in Catalysis Discover an essential overview of recent advances and trends in nanoparticle catalysis Catalysis in the presence of metal nanoparticles is an important and rapidly developing research field at the frontier of homogeneous and heterogeneous catalysis. In Nanoparticles in Catalysis, accomplished chemists and authors Karine Philippot and Alain Roucoux deliver a comprehensive guide to the key aspects of nanoparticle catalysis, ranging from synthesis, activation methodology, characterization, and theoretical modeling, to application in important catalytic reactions, like hydrogen production and biomass conversion. The book offers readers a review of modern and efficient tools for the synthesis of nanoparticles in solution or onto supports. It emphasizes the application of metal nanoparticles in important catalytic reactions and includes chapters on activation methodology and supported nanoclusters. Written by an international team of leading voices in the field, Nanoparticles in Catalysis is an indispensable resource for researchers and professionals in academia and industry alike. Readers will also benefit from the inclusion of: A thorough introduction to New Trends in the Design of Metal Nanoparticles and Derived Nanomaterials for Catalysis An exploration of Dynamic Catalysis and the Interface Between Molecular and Heterogeneous Catalysts A practical discussion of Metal Nanoparticles in Water: A Relevant Toolbox for Green Catalysis Organometallic Metal Nanoparticles for Catalysis A concise treatment of the opportunities and challenges of CO2 Hydrogenation to Oxygenated Chemicals Over Supported Nanoparticle Catalysts Perfect for catalytic, organic, inorganic, and physical chemists, Nanoparticles in Catalysis will also earn a place in the libraries of chemists working with organometallics and materials scientists seeking a one-stop resource with expert knowledge on the synthesis and characterization of nanoparticle catalysis.

Biomedical Applications of Nanoparticles describes the most interesting and investigated biomedical applications of nanoparticles, emphasizing their therapeutic impact. Progress made in the therapy of severe diseases, such as cancer and difficult infections is strictly correlated to the scientific progress and technological development in the field of materials science. Nanoparticles have numerous therapeutic applications, starting with the design of new drugs, delivery systems, therapeutic materials, and their contribution to the development of preventive strategies. The book highlights the impact of nanoparticles on the therapy of infections, antimicrobial effect and also anti-cancer strategies. Successful examples are given throughout the book, along with analysis in order to improve future outcomes of novel therapies. Highlights the term nanotherapeutics and presents several classifications of nanotherapeutics from different points-of-view Presents the recent progress related to nanotherapeutics in the oral cavity Provides the recent progress in the field of biomedical nanoparticles