In recent years, revolutionary technical advances have permitted neuroscientists to map the functioning of the brain in exquisite detail. Of interest are the new techniques that visually display cell energy metabolism which is coupled to functional brain activity in behaving animals. This is the first book dealing with the application of 2-deoxyglucose and related metabolic mapping techniques for brain imaging of behavioral and learning functions. Quantitative autoradiographic techniques based on the use of exogenous markers include radiolabeled glucose and its analogs, especially 2-deoxyglucose and fluorodeoxyglucose. Other mapping techniques are based on the histochemical staining of endogenous metabolic markers such as cytochrome oxidase, as well as immunohistochemistry for expression of c-fos genes. In spite of the great potential capabilities of the new imaging techniques, relatively few neuroscientists are using this approach to study brain functions related to behavior. There is a need to review state-of-the-art applications of these methods in behavioral neuroscience, and to formulate recommendations for future research in this area. This book is intended to fulfill these needs by bringing together leading neuroscientists using metabolic mapping approaches to elucidate brain mechanisms of behavior. Discussions are not limited to one animal species, but they cover a broad range of vertebrates with unique behavioral capabilities.

This book contains selected contributions of papers, many presented at the Second International Workshop on Neural Modeling of Brain Disorders, as well as a few additional papers on related topics, including a wide range of presentations describing computational models of neurological, neuropsychological and psychiatric disorders. It is a unique, comprehensive review of the state-of-the-art of modeling cognitive and brain disorders, appealing to a multidisciplinary audience of clinicians, psychologists, neuroscientists, cognitive scientists, computer scientists, and other neural network researchers. The rest of the book is organized along four main themes, involving memory, neuropsychological, neurological and psychiatric disorders. In general, the cognitive disorders and these psychiatric diseases traditionally regarded as "functional" were modeled along functional lines, while those disorders traditionally viewed as "organic" neurological diseases generally drew more from knowledge of the underlying neurobiology and pathophysiology.

The collection of papers presented covers a range of stimulating memory-related topics, ranging from a study of autobiographical memory, working memory, an investigation into "medial temporal lobe" versus "diencephalic" amnesia (combined with an evaluation of different forms of image analysis), neuroimaging and "psychogenic amnesia", an empirical review paper, a study of incidental retrieval in the context of encoding, a critique of contemporary neuroimaging research (with specific reference to the anatomical lesion literature), a neuroimaging study of memory using event-related functional neuroimaging, a paper concerned with the interpretation and meaning of psychological data obtained from contemporary neuroimaging methodologies, to a submission which questions the view that anatomically "bigger" structures necessarily subserve memory "better". All the contributors to this special edition acknowledge the the intrinsically highly dynamic nature of this field. However, taken together, these papers provide an overview of where neuroimaging data currently place us, with respect to the issue of the neural mediation of memory, and concerning our theorizing about the cognitive architecture of memory processes. Such a review is important and timely: this research perspective, unavailable until just few years go, has already made a considerable contribution to our level of understanding, and, if harnessed appropriately, has considerably more to offer in the future.

First multi-year cumulation covers six years: 1965-70.

An overview of theoretical and computational approaches to neuroimaging.

This book is based on an international symposium titled "Cytochrome oxidase in energy metabolism and Alzheimer's disease," held as a satellite to the 27th meeting of the Society for Neuroscience, New Orleans, 1997. The symposium was dedicated in honor of Dr. Margaret T. T. Wong-Riley because, in our opinion, the cytochrome oxidase histo chemical method introduced by Dr. Wong-Riley in 1979 was the most significant break through to map energy metabolism in the entire brain since the 2-deoxyglucose method introduced by Dr. Louis Sokoloff and colleagues in 1977. Both of these metabolic map ping techniques have made monumental contributions to brain research by allowing an integral view of brain activity. They have also developed into various specialized tech niques, including applications to the human brain. One of these new applications, which is described in detail in this book, is the quantitative cytochrome oxidase cytochemical method used to study Alzheimer's disease. The objective of this book is to describe the role of cytochrome oxidase in neuronal metabolism and Alzheimer's disease. Whether genetic or environmental, the pathogenesis of Alzheimer's disease involves a cascade of multiple intracellular events, eventually re sulting in failure of oxidative energy metabolism. Could impairment of cytochrome oxi dase in energy metabolism initiate the degenerative process? Cytochrome oxidase function and dysfunction are discussed in relationship to neuronal energy metabolism, neurodegen eration, and Alzheimer's disease. The book is made up of 10 chapters, divided into three major parts.

This unique volume focuses on the relationship between basic research in emotion and emotional dysfunction in depression and anxiety. Each chapter is authored by a highly regarded scientist who looks at both psychological and biological implications of research relevant to psychiatrists and psychologists. And following each chapter is engaging commentary that raises questions, illuminates connections with other bodies of work, and provides points of integration across different research traditions. Topics range from stress, cognitive functioning, and personality to affective style and behavioral inhibition, and the book as a whole has significant implications for understanding and treating anxiety disorders.