First multi-year cumulation covers six years: 1965-70.

The germfree animal is reared in the laboratory to be bacteria free; its counterpart, the gnotobiotic animal, is exposed to select microorganisms. The need for such an animal model for use in biomedical studies was first expressed by Pasteur in the late 1800s. Subsequent development of germfree and gnotobiotic animals led to an explosion of studies on the effects of microflora and its components on the physiology and metabolism of the host. Germfree and Gnotobiotic Animal Models brings together the most notable points of early and recent studies and gives reference to the most pertinent literature.

Over 220,000 entries representing some 56,000 Library of Congress subject headings. Covers all disciplines of science and technology, e.g., engineering, agriculture, and domestic arts. Also contains at least 5000 titles published before 1876. Has many applications in libraries, information centers, and other organizations concerned with scientific and technological literature. Subject index contains main listing of entries. Each entry gives cataloging as prepared by the Library of Congress. Author/title indexes.