Genome Engineering via CRISPR-Cas9 System
Title | Genome Engineering via CRISPR-Cas9 System PDF eBook |
Author | Vijai Singh |
Publisher | Academic Press |
Pages | 0 |
Release | 2020-02-21 |
Genre | Science |
ISBN | 9780128181409 |
Genome Engineering via CRISPR-Cas9 Systems presents a compilation of chapters from eminent scientists from across the globe who have established expertise in working with CRISPR-Cas9 systems. Currently, targeted genome engineering is a key technology for basic science, biomedical and industrial applications due to the relative simplicity to which they can be designed, used and applied. However, it is not easy to find relevant information gathered in a single source. The book contains a wide range of applications of CRISPR in research of bacteria, virus, algae, plant and mammalian and also discusses the modeling of drosophila, zebra fish and protozoan, among others. Other topics covered include diagnosis, sensor and therapeutic applications, as well as ethical and regulatory issues. This book is a valuable source not only for beginners in genome engineering, but also researchers, clinicians, stakeholders, policy makers, and practitioners interested in the potential of CRISPR-Cas9 in several fields.
Advances in CRISPR/Cas and Related Technologies
Title | Advances in CRISPR/Cas and Related Technologies PDF eBook |
Author | Dipanjan Ghosh |
Publisher | Academic Press |
Pages | 286 |
Release | 2021-03-05 |
Genre | Science |
ISBN | 0128215917 |
Advances in CRISPR/Cas and related technologies, Volume 179, the latest release in this ongoing series, deals with a wide variety of research topics related to recent advancement in the genome editing techniques. Associated chapters in this new release include Challenges for Therapeutic application of CRISPR Cas techniques, Mitochondrial DNA modification by CRISPR Cas System: Challenges and future direction, Trends in CRISPR Cas technology application in cancer, Modified CRISPR-Cas for next generation application, Application of CRISPR Cas in Synthetic Biology: Challenges and Scopes, History of CRISPR Cas system from bacterial Adaptive Immune System to research application, and more. - Covers the Cas9 protein modification for reduced off-target effect - Includes discussions on Cas9 utilization for Metabolic Engineering - Provides information on the use of Cas9 for targeted delivery in therapeutic application
The CRISPR/Cas System
Title | The CRISPR/Cas System PDF eBook |
Author | Muhammad Jamal |
Publisher | Caister Academic Press Limited |
Pages | 0 |
Release | 2017 |
Genre | Medical |
ISBN | 9781910190630 |
The use of CRISPR/Cas technology for genome editing suggests many potential applications, including the alteration of the germline of humans, animals and food crops. The speed and efficiency of the CRISPR/Cas system make it a potentially useful system for gene therapy. In this volume expert international authors provide a useful and timely review of the applications of the CRISPR/Cas system across diverse fields and explore further avenues and research directions of this novel and powerful editing technology. The technology and its application are reviewed with respect to reproduction and development, immunity and genetic diseases, system structure and system specificity. Some of the potential problems of the CRISPR/Cas system are also discussed, in particular the specificity of the system: this remains an important topic as improvement could lead to the more direct and efficient use of the CRISPR/Cas system in clinical settings. The authors also debate ethical concerns associated with this powerful new technology. This volume is a rigorous review of the applications and new opportunities for the CRISPR/Cas system and provides a stimulus for current and future research. An invaluable guide for all scientists working in the fields of genome editing and gene therapy the book is also recommended for all life sciences libraries.
CRISPR-Cas Systems
Title | CRISPR-Cas Systems PDF eBook |
Author | Rodolphe Barrangou |
Publisher | Springer Science & Business Media |
Pages | 300 |
Release | 2012-12-13 |
Genre | Science |
ISBN | 364234657X |
CRISPR/Cas is a recently described defense system that protects bacteria and archaea against invasion by mobile genetic elements such as viruses and plasmids. A wide spectrum of distinct CRISPR/Cas systems has been identified in at least half of the available prokaryotic genomes. On-going structural and functional analyses have resulted in a far greater insight into the functions and possible applications of these systems, although many secrets remain to be discovered. In this book, experts summarize the state of the art in this exciting field.
CRISPR
Title | CRISPR PDF eBook |
Author | Rodolphe Barrangou |
Publisher | John Wiley & Sons |
Pages | 308 |
Release | 2022-09-14 |
Genre | Science |
ISBN | 168367037X |
“An excellent compendium of all things CRISPR from some of the leading minds in the field. With thorough coverage from every angle and beautifully detailed illustrations, this book is not to be missed!” Jennifer A. Doudna, Professor of Chemistry, Biochemistry & Molecular Biology, UC Berkeley; Founder, Innovative Genomics Institute; Nobel Laureate and coinventor of CRISPR technology “This journey through CRISPR biology and several of its breakthrough applications offers an exciting glimpse into one of the most beautiful and compelling fields in the life sciences.” David R. Liu, Director of the Merkin Institute at the Broad Institute of MIT and Harvard; Professor of Chemistry and Chemical Biology at Harvard University; coinventor of base editing and prime editing “A must read! The CRISPR topics, written by world-leading experts, span from the fascinating mechanistic underpinnings to the ingenious applications. One can read from start to finish or pick and choose themes. Either way, the book delivers utterly enjoyable learning!” Bonnie Bassler, Squibb Professor and Chair, Princeton University Department of Molecular Biology; Howard Hughes Medical Institute Investigator CRISPR-Cas systems have revolutionized the science of gene editing and their possible applications continue to expand, from basic research to potentially groundbreaking medical and commercial uses. Led by a distinguished team of editors, CRISPR: Biology and Applications explores the subject matter needed to delve into this fascinating area. Topics covered include: Classification and molecular mechanisms of CRISPR-Cas systems CRISPR-Cas evolution, regulation, expression, and function Uses for gene editing and modulation of gene expression CRISPR-based antimicrobials and phage resistance for medical and industrial purposes Written by internationally renowned authors, CRISPR: Biology and Applications serves as both an introductory guide for those new to the field and an authoritative reference for seasoned researchers whose work touches this evolving and headline- making science.
CRISPR
Title | CRISPR PDF eBook |
Author | Xin Wang |
Publisher | Nova Biomedical Books |
Pages | 0 |
Release | 2017 |
Genre | CRISPR (Genetics) |
ISBN | 9781536129465 |
Genome editing using CRISPR has been identified as one breakthrough technology in recent research. Today, it is difficult to open a journal or a newspaper without reading about the application of CRISPR gene editing technology to basic research, public health, therapeutics or diagnostics. Although some problems of CRISPR remain to be solved, such as bio-safety and ethical issues, it may change peoples futures. This book is to meet the needs of basic molecular biochemists, pharmacologists, medical students, clinical practitioners and scientists, as well as a broad spectrum of readers who wish to understand the advances in research and applications of CRISPR. The contributing authors are basic scientists as well as students who major in biochemistry and pharmacology. The book presents the current research in the CRISPR model, focusing on its advances and applications. Topics discussed in this compilation include: Targeting of hepatic diseases using CRISPR; applications and advances of CRISPR in animal models; gene targeting on the Cyp2c Locus in rats via CRISPR; applications of CRISPR for therapy in human genetic diseases; utilization of CRISPR in gene function and drug target validation; applications of CRISPR in plant genome editing; and genome editing on human embryos using CRISPR.
Synthetic Genomics
Title | Synthetic Genomics PDF eBook |
Author | Miguel Fernández-Niño |
Publisher | BoD – Books on Demand |
Pages | 106 |
Release | 2022-02-02 |
Genre | Science |
ISBN | 1839696389 |
The current advances in sequencing, data mining, DNA synthesis, cloning, in silico modeling, and genome editing have opened a new field of research known as Synthetic Genomics. The main goal of this emerging area is to engineer entire synthetic genomes from scratch using pre-designed building blocks obtained by chemical synthesis and rational design. This has opened the possibility to further improve our understanding of genome fundamentals by considering the effect of the whole biological system on biological function. Moreover, the construction of non-natural biological systems has allowed us to explore novel biological functions so far not discovered in nature. This book summarizes the current state of Synthetic Genomics, providing relevant examples in this emerging field.