In consultation with Dr. Lucky Jain, Consulting Editor, Drs. Dempsey and EL-Khuffash have chosen a wide range of topics in cardiovascular issues that cover new diagnostic techniques and important areas of management, including the role of volume administration, inotropes, and corticosteroids in the setting of cardiovascular instability. These remain critical questions in neonatal care, and authors were selected based on their expertise and ability to provide the reader with the most recent up-to-date evidence upon which to direct intervention. The clinical review articles in this issue will address the relationship between intervention and outcome in preterm hypotension, the management of cardiovascular instability in the setting of pulmonary hypertension and therapeutic hypothermia, and finally ask if it’s time for a definitive trial in the management of PDA. The final article in the issue highlights the clinical trials to date, what trials are currently ongoing, and what the future holds in cardiovascular support for the preterm infant. The reader will come away with the most current information on this topic from international experts including Europe, Canada, USA, and Australia.

In consultation with Dr. Lucky Jain, Consulting Editor, Drs. Dempsey and EL-Khuffash have chosen a wide range of topics in cardiovascular issues that cover new diagnostic techniques and important areas of management, including the role of volume administration, inotropes, and corticosteroids in the setting of cardiovascular instability. These remain critical questions in neonatal care, and authors were selected based on their expertise and ability to provide the reader with the most recent up-to-date evidence upon which to direct intervention. The clinical review articles in this issue will address the relationship between intervention and outcome in preterm hypotension, the management of cardiovascular instability in the setting of pulmonary hypertension and therapeutic hypothermia, and finally ask if it's time for a definitive trial in the management of PDA. The final article in the issue highlights the clinical trials to date, what trials are currently ongoing, and what the future holds in cardiovascular support for the preterm infant. The reader will come away with the most current information on this topic from international experts including Europe, Canada, USA, and Australia.

The impact of cardiovascular disease on an infant extends from the fetal period to well beyond childhood. Perinatalogists and neonatologists can impact maternal and fetal health through wide range of diagnostic modalities and interventional techniques. For our edition focused on cardiovascular health, we sought to encompass the breadth of knowledge that would be the most relevant for the bed side clinician. Our goal was to assemble contents that would allow a clinician to quickly peruse the journal, and then be prepared to make a medical decision. The interaction between cardiology and perinatology/neonatology includes genetics, diagnostics, interventions, counseling, routine stabilization and day to day care. Ultimately, the goal is to establish the foundation for a healthy adult. For this reason, we have even included chapters on topics that are significant on a day to day basis (such as the proper environment for a newborn) and a long term basis (like the overall neurodevelopmental impact of our interventions). Hopefully, whether in the middle of the night as an emergency reference or during the day as a reliable guide, this edition of Clinics in perinatology will be an important bedside tool for anyone that participates in the care of a patient with perinatal heart disease.

In this issue of Clinics in Perinatology, guest editor Manuel Sanchez Luna brings his considerable expertise to the topic of Respiratory Management. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field; Authors synthesize and distill the latest research and practice guidelines to create these timely topic-based reviews.

Together with Consulting Editor Dr. William Rayburn, Guest Editors Dr. Cynthia Gyamfi-Bannerman and Dr. Russel Miller have curated a state-of-the-art monograph devoted to Advances in Maternal Fetal Medicine. They have secured expert authors to submit clinical reviews for perinatologists. Specific articles are devoted to the following topics: Advances in delivery management for the preterm fetus (magnesium sulfate, late-preterm antenatal corticosteroids); Approaches to stillbirth prevention; Current preterm birth prevention strategies; Neurological outcomes after fetal therapy for complicated monochorionic twins; Innovations in fetal myelomeningocele (fMMC) repair; An update on biologic agents in pregnancy; Telemedicine in obstetrics; The impact of racial and socioeconomic disparities on obstetrical outcomes; Opioids use and misuse in pregnancy; Advances in statewide and national obstetrical QI collaborations; Optimizing term delivery timing and mode of delivery; Preeclampsia; E-Z infections can be quite challenging: Contemporary understanding of Ebola and Zika virus in pregnancy; and Next-generation genetic testing in obstetrics. Readers will come away with the evidence-based recommendations they need to improve patient outcomes. maternal fetal medicine; fetus; pregnancy;

Top authors were selected to write clinical review articles devoted to Advances in Respiratory Care of the Newborn. Articles are devoted to: Effects of chorioamnionitis on lung function and growth; Delivery room respiratory management of the term and preterm infant; CPAP or INSURE for initial respiratory support; Which CPAP is best?; Non-invasive respiratory support; Volume limited and volume targeted ventilation; Weaning from mechanical ventilation; Predictors of bronchopulmonary dysplasia; Brain Injury in Chronically Ventilated Preterm Neonates: Collateral Damage Related to Ventilation Strategy; The Pulmonary Circulation in Respiratory Failure; Novel methods for assessment of right heart structure and function in pulmonary hypertension; Control of oxygenation; Non-invasive monitoring by photoplethysmography; Cell-based strategies to reconstitute lung function in infants with severe bronchopulmonary dysplasia; Permissive Hypercapnea; Prevention of BPD with Nitric Oxide; and Aero-digestive pulmonary disorders in the neonate.