This book describes principles, industry practices and evolutionary methodologies for advanced safety studies, which are helpful in effectively managing volatile, uncertain, complex, and ambiguous (VUCA) environments within the framework of quantitative risk assessment and management and associated with the safety and resilience of structures and infrastructures with tolerance against various types of extreme conditions and accidents such as fires, explosions, collisions and grounding. It presents advanced computational models for characterizing structural actions and their effects in extreme and accidental conditions, which are highly nonlinear and non-Gaussian in association with multiple physical processes, multiple scales, and multiple criteria. Probabilistic scenario selection practices and applications are presented. Engineering practices for structural crashworthiness analysis in extreme conditions and accidents are described. Multidisciplinary approaches involving advanced computational models and large-scale physical model testing are emphasized. The book will be useful to students at a post-graduate level as well as researchers and practicing engineers.

The volatile, uncertain, complex, and ambiguous (VUCA) nature of environmental and operational conditions is still the major cause of marine accidents, with knock-on effects in terms of casualties, property damage, and marine pollution. Recognized as the most effective approach to navigate VUCA environments, risk-based assessment methods provide a solution to address challenges associated with health, safety, and environmental protection in extreme conditions and when accidents involving engineering structures and infrastructure occur. This book serves as a comprehensive guide to the foundational principles, current practices, and cuttingedge trends in quantitative risk assessment and management for ships and offshore structures. With six partsencompassing a total of 35 chapters, it covers risk assessment and management for offshore installations, oil and gas leaks, collisions and grounding, and fires and explosions. Tailored for ship and offshore structural engineers, naval architects, as well as mechanical and civil engineers involved in advanced safety studies, this book is an invaluable resource for both practicing engineers and researchers in this field.• Offers insights into quantitative risk assessment and asset management for ships and offshore structures inextreme conditions and in the event of accidents• Equips engineers with valuable statistical data sets and enhances data assimilation techniques for precisehazard frequency calculations• Seamlessly integrates fundamental principles with practical applications, addressing emerging challengesand leveraging the latest technological advances in the field

This report examines materials research programs across all operating Administrations within the U.S. Department of Transportation. It is the department's first report on ongoing and planned research and technology efforts in advanced materials. The report was published in support of the Administration's initiative to establish an integrated program of research designed to enhance the performance and longevity of the Nation's transportation infrastructure. It is intended to provide the department's customers with a consolidated report of materials-related research projects. The report highlights opportunities for joint research and near-term applications of advanced materials technologies.

The pace and sophistication of advances in medicine in the past two decades have necessitated a growing need for a comprehensive reference that highlights current issues in medicine. Each volume in the Current Issues in Medicine series is a stand‐alone text that provides a broad survey of various critical topics—all accomplished in a user-friendly yet interconnected format. The series not only highlights current advances but also explores related topics such as translational medicine, regulatory science, neglected diseases, global pandemics, patent law, immunotoxicology, theranostics, big data, artificial intelligence, novel imaging tools, combination drug products, and novel therapies. While bridging the gap between basic research and clinical medicine, this series provides a thorough understanding of medicine’s potential to address health problems from both the patient’s and the provider’s perspectives in a healthcare setting. The range of topics covered and the expertise of the contributing authors accurately reflect the rapidly evolving areas within medicine—from basic medical sciences to clinical specialties. Each volume is essential reading for physicians, medical students, nurses, fellows, residents, undergraduate and graduate students, educators, policymakers, and biomedical researchers. The multidisciplinary approach of the series makes it a valuable reference resource for the pharmaceutical industry, academia, and governments. However, unlike other series on medicine or medical textbooks, this series focuses on current trends, perspectives, and issues in medicine that are central to healthcare delivery in the 21st century. Volume 1 focuses on the current issues in basic medical sciences, subjects that are fundamental to the practice of medicine. Specifically, it covers medical biochemistry, genomics, physiology, and pathology. These subjects, traditionally taught in the first two years of medical school that precede clinical instruction, provide a core of basic knowledge critical to the success in clinical medicine during rotations, training, and medical practice.