Chitosan Based Biomaterials: Tissue Engineering and Therapeutics, Volume 2, provides the latest information on chitosan, a natural polymer derived from the marine material chitin. Chitosan displays unique properties, most notably biocompatibility and biodegradability. It can also be easily tuned to modify its structure or properties, making chitosan an excellent candidate as a biomaterial. Consequently, chitosan is being developed for many biomedical functions, ranging from tissue engineering and implant coatings to drug and gene delivery. This book provides readers with a full coverage of the applications of chitosan-based biomaterials. - Presents specific focus on tissue engineering and therapeutics - Provides comprehensive treatment of all biomaterial applications of chitosan - Contains contributions by leading researchers with extensive experience in the material

Oral Delivery of Therapeutic Peptides and Proteins provides a complete overview of the journey scientists pursue to attain protein and peptide oral delivery. The book highlights the physiological challenges that must be accounted for in addition to overcoming protease inhibition and acid stability issues that are commonly mentioned in this area of research. Primary topics include formulation technologies being adopted for oral delivery of proteins and peptides, modification of actives to make them more suited for oral delivery, animal models and their shortcomings in assessing oral bioavailability, and in vitro models to simulate drug absorption and transport. Academics and industry researchers working in formulation development and researchers and advanced students in biotechnology and pharmacy will find this a useful resource. Demonstrates how proteins and peptides transport throughout the gastrointestinal tract and how to evaluate their biological fate when encapsulated into certain delivery systems Examines developing technologies to improve future oral bioavailability Includes the in vitro and preclinical techniques needed for development

This Research Topic is Volume II of the article collection, Cells, Biomaterials, and Biophysical Stimuli for Bone, Cartilage, and Muscle Regeneration Over the last few years, a variety of tissue engineering strategies have been developed to improve the regeneration of bone, cartilage, and skeletal muscle. Numerous studies have proven that physical factors (external mechanical forces, and biomaterials’ features), as well as biochemical factors, may induce cells to reprogram their functions and dynamically adapt to the cellular microenvironment conditions. The advances in understanding the role of biophysical cues in the stem cells microenvironment point out the importance of their application in biomedicine and biotechnology to drive and modulate cell behavior for therapeutic purposes. In this context, many efforts are dedicated to design different strategies to engineer the physical aspects of the natural cellular microenvironment. The development of these technologies may be useful for identifying and studying the physical factors and help to clarify their downstream mechanisms to control cell behavior. This Research Topic will promote an overview of recent advances and cutting-edge approaches based on primary cells, stem cells, extracellular vesicles (EVs), biomaterial scaffolds, bioreactors, biophysical stimuli (e.g., mechanical forces, electromagnetic waves), and biochemical cues. All research involving one or more of the aforementioned cells and methods is welcome to elucidate new basic-research findings (e.g., molecular insights, biochemical pathways toward regeneration) and possible new clinical strategies (e.g., bioreactors for cell factories). An interdisciplinary design (e.g., biology/biochemistry plus bioengineering) is very welcome.

With their advantages of controlled delivery and modular flexibility, biomaterials have fundamentally revolutionized disease diagnosis and therapy. Bioactive nanomaterials are not simple miniaturizations of macroscopic materials. They exhibit unique and intrinsic bioactivities as they readily acquire a precise structure upon interaction with the biological environment. Nowadays, bioactive materials offer great potential in eliciting specific responses and regulations of living tissues for diagnostics, therapeutics, and regenerative medicine. We are optimistic that the increasing innovations and advances in bioactive and biomimetic materials with sophisticated bioactivities and controllable responsiveness will make an important contribution to the next generation of biomaterials and biomedical engineering.

Learn the most up-to-date information on materials used in the dental office and laboratory today. Emphasizing practical, clinical use, as well as the physical, chemical, and biological properties of materials, this leading reference helps you stay current in this very important area of dentistry. This new full-color edition also features an extensive collection of new clinical photographs to better illustrate the topics and concepts discussed in each chapter. - Organization of chapters and content into four parts (General Classes and Properties of Dental Materials; Auxiliary Dental Materials; Direct Restorative Materials; and Indirect Restorative Materials) presents the material in a logical and effective way for better comprehension and readability. - Balance between materials science and manipulation bridges the gap of knowledge between dentists and lab technicians. - Major emphasis on biocompatibility serves as a useful guide for clinicians and educators on material safety. - Distinguished contributor pool lends credibility and experience to each topic discussed. - Critical thinking questions appearing in boxes throughout each chapter stimulate thinking and encourage classroom discussion of key concepts and principles. - Key terms presented at the beginning of each chapter helps familiarize readers with key terms so you may better comprehend text material. - NEW! Full color illustrations and line art throughout the book make text material more clear and vivid. - NEW! Chapter on Emerging Technologies keeps you up to date on the latest materials in use. - NEW! Larger trim size allows the text to have fewer pages and makes the content easier to read.