2023 is the time to collect available knowledge and basic concepts around extracorporeal blood purification in a book that may become the basis for expansion of awareness in the scientific community and a stimulus for new studies and new discoveries by scientists and investigators. We need to answer the question for hemoadsorption that we answered in the last four decades for hemodialysis and CRRT. The pathway towards the new frontier of hemoadsorption starts from this book.

2023 is the time to collect available knowledge and basic concepts around extracorporeal blood purification in a book that may become the basis for expansion of awareness in the scientific community and a stimulus for new studies and new discoveries by scientists and investigators. We need to answer the question for hemoadsorption that we answered in the last four decades for hemodialysis and CRRT. The pathway towards the new frontier of hemoadsorption starts from this book.

SECTION 1: Airway Management -- Current Controversies 1. Can Sellick Maneuver Prevent Pulmonary Aspiration in the Critically Ill? 2. Etomidate vs. Ketamine -- What Should We Use for Intubation in ICU SECTION 2: Extracorporeal Therapies 3. Plasmapheresis: Current Indications in the Critically Ill 4. Are Super High-Flux Membrane Dialyzers the Future of RRT? 5. What is New in Artificial Liver Support Systems? SECTION 3: Sepsis 6. Back to the Genes: Does Genetic Polymorphism have a Role in Sepsis Management? 7. Controversies in Surviving Sepsis Guidelines 2021 8. Are We Back to Square One? Early Fluids vs. Vasopreressors in Septic Shock 9. Have We Achieved Balance in Fluid Therapy: Balanced Salt Solutions vs. Normal Saline? SECTION 4: Biomarkers 10. Novel Biomarkers During Circulatory Shock 11. Biomarkers in Acute Intoxications 12. Do Biomarkers have a Role in Patients with Primary Brain Injury? 13. Utility of MicroRNAs in the Critically Ill 14. Neutrophil to Lymphocyte Ratio in Critically Ill: A Simple but Useful Marker? 15. Do Vocal Biomarkers have a Future in Critical Care SECTION 5: COVID-19 Pandemic: Lessons Learnt 16. Awake Prone Positioning in ARDS? 17. Immunomodulators for COVID-19 Therapy 18. Has Critical Care Telemedicine Come of Age During the Pandemic 19. Post-COVID Conditions (PCCs) or Long COVID Syndrome 20. Capacity Building During Large Scale Disasters 21. Clearing the Air: Alternatives to Isolation Rooms SECTION 6: Mechanical Ventilation 22. Revisiting Exogenous Surfactant Therapy in Acute Lung Injury and ARDS 23. Mechanical Power 24. Volumetric Capnography in 2022 25. Metabolic Alkalosis in Critical Care: A Classical and Physicochemical Approach 26. Oxygen Revisited SECTION 7 28. High-flow Nasal Cannula: Beyond a COVID-19 Therapy 29. Cefiderocol 30. Newer Fluoroquinolones: Levonadifloxacin, Delafloxacin and Lascufloxacin 31. Newer Combinations of B-Lactam/B-Lactamase 32. Newer Tetracyclines -- Eravacycline and Omadacycline 33. Plazomicin: A New Aminoglycoside 34. Lefamulin: A Pleuromutilin Antibiotic 35. Pretomanid for Antitubercular Therapy 36. Contezolid Acefosamil: A New Oxazolidinone 37. Solithromycin and Nafithromycin: The New Macrolides 38. Benapenem and Sulopenem 39. The Dsb (Disulfide bond) 40. Antivirulence Strategies: The Future of Antibacterial Therapy 41. Alternatives to Conventional Antibacterials: Use of Nanomaterials 42. Newer Treatment Approach to Clostridioides Difficile - Fidaxomicin and Bezlotoxumab 43. Recent Advances for Immunotherapies Against Infectious Disease SECTION 8: What's New Elsewhere? 44. Risk Scoring Systems in Upper Gastrointestinal Bleed 45. Has Hypotension Prediction Index Come of Age 46. Postintensive Care Syndrome and Postintensive Care Syndrome-Family 47. Closed-Loop Hemodynamic Resuscitation In Shock 48. Is Electrical Impedance Tomography Finally Here to Stay 49. Cardiac Output Measurement: Capnodynamic Method and Auto VTI Tool 50. What's New in Glucose Management Technologies for the Critically-ill 51. Vitamins and Trace Element Supplementation for Critically Ill Patients in 2022 Index

This book brings together papers presented both during the 61st Annual Meeting of the Japanese Society for Dialysis Therapy (JSDT) and the 34th Congress of the International Society of Blood Purification (ISBP), held in Osaka in June and in Hiroshima in September 2016, respectively. They cover a broad spectrum of topics, ranging from hemodialysis, peritoneal dialysis, hemodiafiltration and technical innovations in blood purification to complications of chronic kidney disease and acute kidney injury, including mineral bone disease and anemia.

Particle Separation Techniques: Fundamentals, Instrumentation, and Selected Applications presents the latest research in the field of particle separation methods. This edited book authored by subject specialists is logically organized in sections, grouping the separation techniques according to their preparative or analytical purposes and the particle type. Along with the traditional and classical separation methods suitable for micronic particles, an update survey of techniques appropriate for nanoparticle characterization is presented. This book fills the gap in the literature of particle suspension analysis of a synthetic but comprehensive manual, helping the reader to identify and apply selected techniques.It provides an overview of the techniques available to a reader who is not an expert on particle separation yet about to enter the field, design an experiment, or buy an instrument for his/her new lab. - Presents a resource that is ideal for anyone preparing samples across a variety of fields, including pharmaceuticals, food science, pollution analysis and control, agricultural products, and more - Includes real case examples discussed by leading experts in the field - Provides chapters that contain a unique, common table that summarizes points-of-strength and the weaknesses of each technique

The deterioration of water quality and unavailability of drinkable water are pressing challenges worldwide. The removal of toxic organic and inorganic pollutants from water is vital for a clean environment, as a response to water scarcity. Adsorption-based water technologies are among the most widely used because of their high efficiency and low cost, without relying on a complex infrastructure. In recent years, carbon nanomaterials (CNMs), such as graphene and derivatives, carbon nanotubes, carbon nanofibers, nanoporous carbon, fullerenes, graphitic carbon nitride, and nanodiamonds have been extensively exploited as adsorbents due to their extraordinary surface properties, ease of modification, large surface area, controlled structural varieties, high chemical stability, porosity, low density, ease of regeneration, and reusability. This book provides a thorough overview of the state of the art in carbon nanomaterials as they are used for adsorption applications in water purifications, as well as addressing their toxicological challenges. This volume primarily explores the fundamentals of adsorption, its mechanical aspects, synthesis and properties of CNMs, and adsorption performances of CNMs and their nanocomposites with organic and inorganic materials. Structural engineering and activation processes produce materials with enhanced adsorptive properties and separation efficiencies. Furthermore, the formation of CNMs with 2D and 3D macro-and microstructures and high porosities is a potential approach to improve adsorption performances and extend CNM use at the industrial level. The book also addresses important issues regarding these adsorbents that potentially affect future research and industrial applications of carbon-based nanoadsorbents in water security. - Presents advances in multifunctional 3D superstructures of carbon nanomaterials and their composites for adsorption applications - Outlines the fundamentals on synthesis and characterization techniques of carbon-based nanostructures and their composites - Assesses the major toxicological challenges in using nanostructured materials as adsorbents for water purification

Artificial Cells are not to reproduce biological cells but to prepare an artificial system for possible uses in medicine and other areas. Many of the ideas on artificial cells are being extensively applied and extended by researchers worldwide, resulting in rapid and exciting progress and discoveries. Different configurations include using emulsion methods and microfluidizers to form microscopic or nano dimension cells called artificial cells, synthetic cells, microcapsules, nanocapsules, liposomes, microparticles, nanoparticles, polymersomes, etc. Macro dimensions artificial cells are used for bioencapsulated cells. Soluble nanobiotherapeutics can be formed by crosslinking proteins and enzymes or by PEG conjugation. The principle of artificial cell has now evolved into nanomedicine, biotherapeutics, blood substitutes, drug delivery, enzyme/gene therapy, cancer therapy, cell/stem cell therapy, nanoparticles, liposomes, bioencapsulation, replicating synthetic cells, cell encapsulation, biosorbent/immunosorbent hemoperfusion/plasmapheresis, regenerative medicine, encapsulated microbe, COVID_19 vaccine, COVID_19 therapy, nanobiotechnology, nanotechnology and other areas.